Protein Alignment ACXC and gcy-4

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_496218.2
• Gene: gcy-4 / 191642
• WormBaseID: WBGene00001531
• Length: 1136
• Species: Caenorhabditis elegans
• Alignment Length: 1098
• Identity: 212/1098 - (19%)
• Similarity: 367/1098 - (33%)
• Gaps: 367/1098 - (33%)

  Fly   174 IKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTM- 237
            |:...|..:|...::|...|.|:.|..    :.|.|...::..     |...:...|.:..|.|
 Worm   244 IQAGLLGMNSSEYVHVMLSMRSVGFGV----QTSVGKKPLTLS-----GLPPIWESFTVNPDGME 299

  Fly   238 -------VRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDR 295
                   .:...:|....:.::|:|::  :.::|:. :|..|.::..|.|.:.:..|
 Worm   300 DLAKSVAAKMIVIDTSSEVRDKTFLQY--MTKNIVY-AIREPPLSCKVPECLITNAT-------- 353

  Fly   296 FQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLV---------------------- 338
             .||......|       ||..:|...|:..:.|.....|||.
 Worm   354 -GMGAYARHLF-------DVFYMYGMAVSSLNSTDPNVYGNLSLLIPKFTTAFEGMTGEVKLNED 410

  Fly   339 ---KVLHDLYG---------RFDIAASNFKVQRIKFLGD----CYYCVAGLTTPDPDHAKCCVSL 387
               |.|:.:||         ..||:..|..|..:....|    .::...|...||   ...|..|
 Worm   411 LARKPLYQVYGLNSEYDQISLIDISLINDTVNVVFNYADGNTEVWHFWGGTRPPD---TPVCGFL 472

  Fly   388 G------------------------------ISMISNIQEVRAERGL--------DIDMRIGVHS 414
            |                              |.|.|.|:..|.|:..        .|.:|:.:|.
 Worm   473 GKSCPLPIFEQYRALVIVAIAVTILILLAIIICMSSKIRNRRVEQSRLHSEWQIHAIKLRLPMHR 537

  Fly   415 GSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDP 479
            .:        :|...:   ::.|.|:..|:     :...||.|::......|||
 Worm   538 RA--------SKSSQE---SETESASETEN-----FTSKSGDTMTSEFKETYTI----------- 575

  Fly   480 VLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGG 544
              ||:...|:         :|:...|:..|..|:....::|       .:..|...:|..:.:.|
 Worm   576 --QYLENDLV---------LTTAHQVQELSQAEMMKFVKLR-------KLDHENLNKFIGLSIDG 622

  Fly   545 ---INLNSPCCRRTRLDTHKKTQREIG---IFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGC 603
               :::...|.|.:..|...|....:.   :|| ..:|.:...:|:|:       |.|...|
 Worm   623 SRFVSVWKMCSRGSLQDIISKGSFSMDYFFMFC-MIRDIAEGLHYIHK-------SFLRHHG--- 676

  Fly   604 CLIYIQIVTNNFSCTACIV-----VDLVTF--FFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYSC 661
                      |.....|:|     |.|..|  .||.......:.||:.|...
 Worm   677 ----------NLRSATCLVNDSWQVKLADFGLQFLQDEEEKPFKKNMLWAAP------------- 718

  Fly   662 MAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELS-----YIESKIYHYEMDRD 721
                  |.|:.|:|:........::|:..|.|.|:..  |:.::||     |.|.|   |.:.:.
 Worm   719 ------EVIRGSLSIEQMDSSADIYSFAIVASEILTK--REAWDLSRRKEGYEEIK---YAVKKG 772

  Fly   722 TCFHPWVFTNMISLILGISYTFARIPFGLKIVISC-CETLAYLLIVFFQFAFIFQHSATTTPFMK 785
            ..|   |....:.:.:.::.|.      |.:|..| ||.                         .
 Worm   773 GQF---VLRPDLHIDIEVNQTL------LALVKDCWCEN-------------------------P 803

  Fly   786 AELAHCLRVCMMLLTMYAKERQS----EFNTKMNY--KLNVDLQNKQKAADLTNQSIIILLNNIL 844
            .|......||.:|..|......:    .|:....|  .|.|::..:.|...|..:...|||..:|
 Worm   804 EERPSAENVCKVLFDMTPNTEDNLMDHVFSMLEEYTSSLEVEVGERTKELTLEKKKSDILLGRML 868

  Fly   845 PSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFDRLLT 901
            |..|.:   ...|...:..|::.:|:|.|:.|:.|        |..:.:|  |||:.:.||.::
 Worm   869 PKQVAE---RLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQVVNL--LNDVFSNFDSII- 927

  Fly   902 AYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVE---------VEHARNHRMT 957
               |.:.|.|::.:|..::...||.            .||...|:.         :|..||.|:
 Worm   928 ---EKHDVYKVESIGDGFLCVSGLP------------NRNGMEHIRQIVGMSLCFMEFCRNFRI- 976

  Fly   958 DENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGA 1022
                 ..:..:.|                                  ::.:||:||..:|||||.
 Worm   977 -----PHLPRERV----------------------------------ELRVGINSGPCVAGVVGL 1002

  Fly  1023 SQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL---QEFDIKCIYRGMTFVKGRGDIPTYF 1084
            |.|.|.::|:.||.||||||.|.|..|.::|.:..:|   ..:..:...||...:||:|.:.||:
 Worm  1003 SMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLVNNYPYQFETNSRGEVIIKGKGVMETYW 1067

  Fly  1085 VGIDENL-------------------KFMSAKLVN---RSLSRRFSVMSSLDPDSLRK 1120
            :....:|                   .|..::|.|   ||:|.....:|..|.:.:|:
 Worm  1068 LLGKMSLSNQSTPPITKVNHKPRKIASFTDSELTNYSFRSVSPYVENLSDNDDEEIRR 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	21/118 (18%)
		CYCc	293..468	CDD:214485	43/250 (17%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	39/234 (17%)
		CYCc	833..1060	CDD:214485	60/246 (24%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	60/243 (25%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	42/240 (18%)
		ANF_receptor	49..423	CDD:279440	37/206 (18%)
		PKc_like	558..819	CDD:304357	67/368 (18%)
		HNOBA	<834..876	CDD:285003	11/44 (25%)
		CYCc	855..1047	CDD:214485	61/252 (24%)
		Guanylate_cyc	882..1070	CDD:278633	60/245 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900