DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gcy-11

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	316	Identity:	72/316 - (22%)
Similarity:	144/316 - (45%)	Gaps:	40/316 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 SSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTD-ILHNLGFNMMGIFFRIMNDTMVRASFLDR 245
            |.:.|.....:..::....:|..:..||.|::.:| |:..|.|...|...|.....:.:|.:  .
Worm   796 SKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPY--P 858

  Fly   246 HQFIMEETWLRHALLQESI-----------------LLDSI--LPPQIAKPVQEKIKSKITQSEN 291
            ...::|:.|:.....:.||                 :.|:|  |..:....:::.||.:..|.|:
Worm   859 LASVVEKCWVEDPASRPSIKKVRELLKPLSKGLKGNIADNIMNLLDRYRNNLEDVIKERTEQLED 923

  Fly   292 SPDR-----FQMGPRTTESFMA------IQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLY 345
            ...|     .|:.|::..:.:.      .:.:..|||.::|:|.:|.|::..|...:|.:|::||
Worm   924 ERKRNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLY 988

  Fly   346 GRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPD---HAKCCVSLGISMISNIQEVRAERGLD-- 405
            ..||.....|...:::.:||.|..|:||  |:.:   ||....|..:.::.:|:........|
Worm   989 TNFDTIIDKFDCYKVETIGDAYMFVSGL--PEVNSYLHAGEVASASLELLDSIKTFTVSHCPDEK 1051

  Fly   406 IDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSML 461
            :.:|||.|:|.::.|::|....::.::|..|.|||.:||:|||..:.:|.....::
Worm  1052 LRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDAYELI 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	22/122 (18%)
		CYCc	293..468	CDD:214485	48/185 (26%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	45/166 (27%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743	17/95 (18%)
		CYCc	923..1116	CDD:214485	48/187 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900