Protein Alignment ACXC and acy-4

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_504486.4
• Gene: acy-4 / 178949
• WormBaseID: WBGene00000071
• Length: 1013
• Species: Caenorhabditis elegans
• Alignment Length: 1132
• Identity: 286/1132 - (25%)
• Similarity: 479/1132 - (42%)
• Gaps: 271/1132 - (23%)

  Fly    31 WEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVI 95
            ||....|:..::......|.:|..::....:...:|:.:.:.:|......     :.|.:...:|
 Worm    64 WEKLRYRKNSQKKKRSTLYSFYFEQVNSGRIQFSFVILLSICISEAAFSA-----FGAEWLKSLI 123

  Fly    96 RVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTSFDVF 160
            ..:.| ||:::||. |..|   |...|.|||.:..|.:...|.              :.||....
 Worm   124 LCILT-LVISILSF-FHAK---RTELVCIASIISCVIISACTS--------------MRTSVTYL 169

  Fly   161 TLCMIYMFLPIPSIKGAALLASSVSLIY-VAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFN 224
            .:...|..||:..:   .::.|:.:|.: |||....:.:|.        |:|:|.|.::..:..|
 Worm   170 LIFSTYSLLPMSFM---LMIFSTFALTFLVAFIGVLMDYNV--------GFDIILTRVMMVILVN 223

  Fly   225 MMGIFFRIMNDTMVRASFLDRHQFIMEETWL-RHALLQESILLDSILPPQIAKPVQEKIKSKITQ 288
            ::|.......:.:.|.:|.:..:.:.....| :....||.||| ::||..||..|::.::
 Worm   224 VVGSLVYYPTEFVQRKTFHETRKCVQSRMLLDKEMHRQEKILL-AVLPKNIAFEVKKDMQ----- 282

  Fly   289 SENSPDRFQMGPRTTESFMAIQI--HPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIA 351
             |...:|.         |..|.|  :.|:|||:||:..:|:|.:.....:||.:|::|:.|||..
 Worm   283 -ETHEERM---------FHKIYIRKYEDISILFADICGFTNLASEYNPKDLVLMLNELFARFDKV 337

  Fly   352 ASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGS 416
            ||..:..|||.||||||||.|:.....:||...|.:|..||..|:.||....::::||:|:|:|.
 Worm   338 ASIHQCMRIKILGDCYYCVCGVPEYQKNHAINTVEMGRDMIEAIRLVREMTLVNVNMRVGIHTGK 402

  Fly   417 LLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGT--------- 472
            ...|::|..|.|||:|..||.:||.:||.|..|.||::..|.|.|..| |.:..|.
 Worm   403 AHCGVLGLKKWQFDVWSNDVTLANQMESGGLAGRVHITDATRSYLKGA-YILEEGNGGSRSKFLE 466

  Fly   473 --------------------QKAQSDPVL-------QYIHTYLLTGQVARESFITSIGGVRSSSV 510
                                |:|.:.||:       .......|||...|....::..|:....|
 Worm   467 KEKIKTWLVVDRSPDYDNICQEATNHPVMVPWKSTRGISKQERLTGMSTRTRGASTRNGLSEEEV 531

  Fly   511 LEVKSID-RIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFCAAF 574
            | |:::| .:|      ..:....:|.::.|.          |:...|               .:
 Worm   532 L-VENVDSHLR------QGIQAIHQENWKTMH----------CKNWSL---------------KY 564

  Fly   575 KDSSLEWNY--LHQPDFIFKSSM---LLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSL 634
            |...:|..:  |...|..|:.::   ::|..||.....:.:|:.:|.....||:..|..|.||..
 Worm   565 KQVRVENKFVRLKYKDIPFQVTLYVAIVAICIGIKFGLMNLVSFSFVPQMFIVLTSVMIFILTRA 629

  Fly   635 LCLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNC 699
            |                                  |:|  :..:::.:|:||...::..:|::.
 Worm   630 L----------------------------------IKH--ARLVSLVIGVLFILLSIQIVILMG- 657

  Fly   700 DRDMYELSYIESKIYHYEMDRDTCF--HPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAY 762
               ||     |||   :..|.:.||  :...|..:..:....:.....:.|..|:::|.....::
 Worm   658 ---MY-----ESK---FTCDVEKCFKNNYTDFFEIFEICTLATCVILSVDFMTKLLMSMIYFSSF 711

  Fly   763 LLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNY-----KLNVDL 822
            .:::..:...|.|:.|..:.:..    .|:..|:.||.:....|:||..::.::     .|:..|
 Worm   712 TVLITAKLIRINQYEALLSTYAN----FCVLSCLTLLLVVFSTRRSELISRYDFIWKLQALDEQL 772

  Fly   823 QNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKH---------ELYYENYRMVSVMFAMLIN 878
            |.|:|...  |:|:   |.|||||||        |||         :||:|:.....:|||.|..
 Worm   773 QMKRKHEQ--NRSV---LENILPSHV--------AKHFVEDATSVSKLYHESRDNACIMFATLTE 824

  Fly   879 FPM----------NLPSLRVLNDIITQFDRLLTAY---REYYVVEKIKVVGCTYMAACGLDFNLA 930
            |..          .:..||:||:||:.||::|...   .|:..:||||.:..|||.|.||.....
 Worm   825 FDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGLAGREC 889

  Fly   931 SNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSS 995
            .:        ||  |||.                         :..||.:|:..|.:.|
 Worm   890 GD--------NS--HVEA-------------------------IALFARELLVKLESTN------ 913

  Fly   996 FFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQ 1060
              ..|.:...:.|||:.|.::|||:|:.:||||||||.||:||||:|.|:.|.||||||...||:
 Worm   914 --IHSFNNFNLRIGINVGPVVAGVIGSDKPHYDIWGNSVNVASRMDSGGVAGRIQVTEEVKSILE 976

  Fly  1061 E--FDIKCIYRGMTFVKGRGDIPTYFV 1085
            .  ::.:|  ||...|||:|.:.|:|:
 Worm   977 PLGYNFEC--RGQINVKGKGMMETFFL 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	51/253 (20%)
		CYCc	293..468	CDD:214485	69/176 (39%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	66/160 (41%)
		CYCc	833..1060	CDD:214485	84/248 (34%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	80/238 (34%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831	55/277 (20%)
		CYCc	260..451	CDD:214485	79/207 (38%)
		Guanylate_cyc	293..448	CDD:278633	64/154 (42%)
		CYCc	778..984	CDD:214485	85/261 (33%)
		Guanylate_cyc	807..1003	CDD:278633	81/240 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910