Protein Alignment ACXC and acy-1

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_497970.1
• Gene: acy-1 / 175622
• WormBaseID: WBGene00000068
• Length: 1253
• Species: Caenorhabditis elegans
• Alignment Length: 1386
• Identity: 285/1386 - (20%)
• Similarity: 518/1386 - (37%)
• Gaps: 463/1386 - (33%)

  Fly     6 TNSRKSPLKRKRLRPCHLDYANERLWEHSYLRE-------KCKELNLEEEYR--YYQVRLMVSNL 61
            ::.|:.||         .:.|:.|.|...:...       ||....|.:.:|  ...:.::::..
 Worm    25 SSPRRVPL---------FERASARWWNPQFRSATLEAQYWKCSFSQLRDRFRSGLIYIAVVIAAW 80

  Fly    62 TIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIAS 126
            |::..||          :..::||:       ::.:....::..:.:...|   .::::...:.:
 Worm    81 TLYLALF----------DRTFIQHW-------IVSLCLCAIIFAMFAFTAC---AAQYQRFYMPT 125

  Fly   127 SVLSVYLVVLTDIVMISYH----FYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLI 187
            |.|..:|:.|..:::.|..    |......|.|||.|  :.:||..:|:|     ..|...:.:|
 Worm   126 SFLCTFLICLVTLLIFSAENQAAFMTPVASLATSFQV--VLLIYTVIPLP-----LYLCILIGII 183

  Fly   188 YVAFFMHSLTFNAVYTDR---DSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFI 249
            |      |:.|..:..::   :..||..:   :|| .|.:::|:...|:.....|.:||...|.:
 Worm   184 Y------SILFEILNKNKIGLEEAGYIKL---VLH-AGVHLLGVHLFILTQVRQRKTFLKVGQSM 238

  Fly   250 MEETWLRHALLQESILLDSILPPQIA----KPVQEKIKSKITQSENS----------------PD 294
            :....|......:..::.|::|.::|    |...|..:...:...|.                |:
 Worm   239 LARKDLELETQFKDHMIQSVMPKKVADELLKDASELRRPSASNDSNCRTSNATQVDQPLAKMVPE 303

  Fly   295 RFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQR 359
            ..:..|.|      :.:..:||||:||:..:|.:::..:...||.:|:||:||||.......:::
 Worm   304 YRKFRPFT------MNLMTNVSILFADIAGFTKMSSNKSADELVNLLNDLFGRFDTLCRLRGLEK 362

  Fly   360 IKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGE 424
            |..||||||||||...|..|||...|.:|:.||..|::...:||.:::||:|:|:|.::.|::|.
 Worm   363 ISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRGQEVNMRVGIHTGKVMCGMVGT 427

  Fly   425 AKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSML-------NPADY-----TILSGTQKAQS 477
            .:.:||::..||.:||.:||:|..|.||||..|..:|       ...||     ..:.||::...
 Worm   428 KRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIEEGPDYDGPLRMQVQGTERRVK 492

  Fly   478 DPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPS-QSSMTDEFREEFR--- 538
            .   :.:.|:.:.|::.        .|| ...|::|:.::.:.|.:.| :|::..::.|:.:
 Worm   493 P---ESMKTFFIKGRIN--------DGV-EEEVMQVQEVESLHSQKSSKKSTLKQKWAEKLKMNH 545

  Fly   539 --NMPV------GGINLNSPCCRRTR--------------LDTHKK------------------- 562
              :.|:      ||.:|......|.|              ::.::|
 Worm   546 TNSYPMRAAAREGGGSLRIKLAERNRSTQLLPKESNSICIMEDNRKSASLQALATNNFNGSNTDT 610

  Fly   563 --TQREIGIFCAAFKDS-------------------SLE-------------------------- 580
              |..|.|:..:..|.|                   ||:
 Worm   611 NNTYSERGVAGSVSKKSVAGSESNSIKGSRSSGLQLSLQDGNSDLNSVGGLDTAISHHHNAASLT 675

  Fly   581 ---------------------------WNY----------LHQPD--------FIFKSSMLLAW- 599
                                       ||:          .::.|        |:..|....|.
 Worm   676 RFDTDNNFDQRLAMVIGQGEGGFDKGFWNHHDSLNKWTLRFNEKDVEEEYRAHFVDSSERYTASK 740

  Fly   600 ------------------GI-GCCL-------IYIQIV--TNNFSCTACIVV--------DLVTF 628
                              || |..:       ::|.|:  |..|..:..:.:        .|:.:
 Worm   741 KGHVERHKDLMEQGGEKDGITGSTVNKYRYSGVFIDIIVATLIFVISGAVAIMSVRPFPLSLIAY 805

  Fly   629 F-FLTSLLCLAWYKNVCWWKSGRYEFRIYG--------KYSC--------------------MAF 664
            | |..::|.|.              ..:.|        .:.|                    :|.
 Worm   806 FPFAAAILILT--------------IVLIGLPLLARKKSFQCANQWMPRHLIGLLLIFLPIGVAI 856

  Fly   665 HIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYE------------------LSYIES 711
            .|....|......:.:...:.|||..::: |..:|:.....                  :.|.|.
 Worm   857 CIMPLCQSGDCANVILNYRLAFSYVTILA-IFAHCNFSQLAAWPKTTAAVFIGLLHIAGVFYCEF 920

  Fly   712 KIYHYEMDRDTCFHPWVFTNMISLIL-----GISYTFARIPFGLKIVISCCETLAYLLIVFFQFA 771
            .:.|...::|||       |:.::::     |::||.|
 Worm   921 NLKHLVEEQDTC-------NVTAIMIPPIRKGLNYTIA--------------------------- 951

  Fly   772 FIFQHSATT------TPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAAD 830
             :...||.|      :|....||  .|.|.:.::.:.....|.|...:|::..:|..:...:...
 Worm   952 -LNSTSARTLSQDFGSPLFIWEL--LLDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQ 1013

  Fly   831 LTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLI--------NFPMNLPSLR 887
            :.......||||::|:|.|:    ||.....|.||:..|.|:||.:.        ||......||
 Worm  1014 IVRDQADWLLNNVIPAHAVE----SLKTDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLR 1074

  Fly   888 VLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHAR 952
            |||::|..||.||.. .::..:||||.:|..||||.||:.....|:.               |.:
 Worm  1075 VLNEVIGDFDELLDR-PDFTHIEKIKTIGPAYMAASGLNPERKKNML---------------HPK 1123

  Fly   953 NHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKIC-IGISSGEIM 1016
            .|                ::.|..|||.:...|        |.|.|..|:...:| :|::.|.:.
 Worm  1124 EH----------------LYQMVDFALAVQHVL--------SVFNEDLLNFDFVCKLGLNIGPVT 1164

  Fly  1017 AGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL---QEFDIKCIYRGMTFVKG-R 1077
            |||:|.::.:|||||:.||:||||.|||:...|||::.:.:.|   .||:    :|....||| .
 Worm  1165 AGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQHTREYLLDRYEFE----FRDHIEVKGID 1225

  Fly  1078 GDIPTYFV------GIDENLK 1092
            |.:.||.:      ||..::|
 Worm  1226 GGMDTYLLVGRKGDGIPPSIK 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	47/271 (17%)
		CYCc	293..468	CDD:214485	66/186 (35%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	61/165 (37%)
		CYCc	833..1060	CDD:214485	76/238 (32%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	76/236 (32%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686	26/112 (23%)
		CYCc	297..469	CDD:214485	64/177 (36%)
		Guanylate_cyc	317..503	CDD:278633	66/188 (35%)
		SDF	<773..982	CDD:294387	38/260 (15%)
		CYCc	1016..1215	CDD:214485	78/246 (32%)
		Guanylate_cyc	1041..1235	CDD:278633	76/237 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810