DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXC and gcy-12

DIOPT Version :9

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:NP_494995.2 Gene:gcy-12 / 173902 WormBaseID:WBGene00001538 Length:1679 Species:Caenorhabditis elegans


Alignment Length:1239 Identity:233/1239 - (18%)
Similarity:398/1239 - (32%) Gaps:481/1239 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 QVRLMVSNLTIFYVLFIILAMSFLTIE---LLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEK 114
            ::.|...|:.:|..:..|:....||.:   |:||.                              
 Worm   330 RIYLTFDNVRLFRTMLSIMGEMGLTQQDYMLIYVD------------------------------ 364

  Fly   115 FVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKN-------DWPLNTSFDVFTLCMIYMFLPIP 172
              :.:.|:.:..|              ::.||.:|       .|..|.|.|              
 Worm   365 --TNYDWLNVYHS--------------MNNHFLRNTMTYLHHSWDANNSSD-------------- 399

  Fly   173 SIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTM 237
             .|......|::|:|.....::|..|         :.:...:.|.:|:.|              :
 Worm   400 -RKMLDYARSALSIIPTPVKLNSQRF---------YNFWKKAGDYMHHFG--------------V 440

  Fly   238 VRASFLDRHQ---FIMEETWLR----HALLQESILLDSILPPQIAKPVQEKIKSK---------- 285
            .:|..|..::   ::.:..:|.    |.|::|....||..|....|.:.::|.:|          
 Worm   441 QKADNLKGNRIACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDM 505

  Fly   286 -ITQSENSPDRF------QMGP---RTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKV 340
             |.:..||...|      ::.|   ::..|:..:....|::.::.:..:...|.      ||   
 Worm   506 RIDERGNSKGNFSLLSWQKVAPIMNKSDPSYYPLDHALDLTAIFVEAPDKDRLP------NL--- 561

  Fly   341 LHDLYGRFDIAASNFKVQRIKFL-GDCYYCVAGLTTPDPD------HAKCCVSLGI--------- 389
                         .||..||::| |:          |.||      |.:.|...||         
 Worm   562 -------------QFKSSRIQWLKGE----------PPPDEPVCGFHGENCRKKGIFSYLTVVVM 603

  Fly   390 ------SMI------SNIQEVRAERGLDIDMRIGVHS-GSLLAGIIGEAK---LQFDI------- 431
                  |::      :.|:..|.|:.|.:..:|..:. ..::.|:..|:.   :|.|:       
 Worm   604 ILIAVFSLVLTGFTLNYIRSRRFEKELSMIWKIDPYEVRRVVGGVNNESTASLMQSDVMQFAKTK 668

  Fly   432 --WGTDVEIANHLESTGEPGYVHVSGRTLSMLN------PADYTILSGTQKAQSDPVLQYIHTYL 488
              |.:...:    :.||..|.....|..:.:.:      |.|   |:...|.:...:.|..|..:
 Worm   669 TPWWSKAPV----QGTGMRGLASYKGTLVGLKDLMYGRKPKD---LTREAKKELRAMRQLAHPNV 726

  Fly   489 LTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCR 553
                   .:|:..|  |...||..|:..       .|:.|:.|..|.|         ||      
 Worm   727 -------NNFLGII--VCQYSVTVVREY-------CSKGSLHDILRNE---------NL------ 760

  Fly   554 RTRLDTHKKTQREIGIFCAAFKDSSLE-WNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSC 617
              :|| |        ::.|:|.|..:: ..|:|       .|.|...|             |...
 Worm   761 --KLD-H--------MYVASFVDDLVKGMVYIH-------DSELKMHG-------------NLKS 794

  Fly   618 TACIVVDLVTF----FFLTSLLCLAWY-------KNVCWW-------------------KSGRYE 652
            |.|::....|.    |.|..|.....|       :|..|.                   |:..|.
 Worm   795 TNCLITSRWTLQIADFGLRELREGIMYDSSYNIWENFLWTAPEAMTINGSLAISNPPTPKADAYS 859

  Fly   653 FRIYGKYSCMAFH-IFEK-------IQH------------SVSLRITVYLGILFSYYAVISLIML 697
            |.|       .|| ||.:       :|.            ||..|            |::...:.
 Worm   860 FGI-------IFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECR------------ALVEKTVR 905

  Fly   698 NCDRDMY---ELSYIESKIYHYEMDRDTCFH--PWVFTNMISLILGISYTFARIPFGLKIVISCC 757
            ....|.|   :.|.:|.:.|..|: ...|:|  |                :.|..|         
 Worm   906 RVYSDPYFRPDTSDLEVQNYVKEV-MAACWHHDP----------------YQRPEF--------- 944

  Fly   758 ETLAYLLIVFFQFAF---IFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLN 819
            :|:...|...|...:   |..|                    |:|.|...:.|.|   .:..:..
 Worm   945 KTIKNKLKPLFHQIYKQNIMDH--------------------MVLMMEKYQTQLE---DLVDERT 986

  Fly   820 VDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINF----- 879
            ::|:::|:.:.       .||..:|||.|.:   ..||..::..|.:..|::.|:.::.|     
 Worm   987 IELKDEQRRSQ-------HLLQRMLPSSVAE---QLLAGQDVIPEAFPPVTIYFSDIVGFTTISG 1041

  Fly   880 ---PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRN 941
               ||.:  :..||.:.|.||.::..|..|    |::.:|..||...|:           ..::.
 Worm  1042 ESTPMEV--VTFLNKLYTLFDSIIRRYDVY----KVETIGDAYMVVSGV-----------PQYKT 1089

  Fly   942 SSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKI 1006
            ...|.                      |.:.:|....|..:|         |.|...||.....|
 Worm  1090 MEYHA----------------------EQIAMMAIHILSAVR---------SFSIPHRSCEPLMI 1123

  Fly  1007 CIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIY--R 1069
            .||:.:|..:|||||.:.|.|.::|:.||.||||||.|....|..:..:.|:|...|...:.  |
 Worm  1124 RIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEER 1188

  Fly  1070 GMTFVKGRGDIPTYFVG----------IDENLK----FMSAKLVNRSLSRRFSVMSSLDPDSLRK 1120
            |...:||:|.:.||::.          |::.:.    |....|.||..|...:..|||   ||..
 Worm  1189 GSLAIKGKGQMTTYWLNGRAGYEFTETIEDKMVVPDIFPRPNLKNRGSSWGVNRESSL---SLAT 1250

  Fly  1121 SSSS 1124
            ..||
 Worm  1251 EKSS 1254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 AC_N <33..285 CDD:292831 38/248 (15%)
CYCc 293..468 CDD:214485 37/230 (16%)
Nucleotidyl_cyc_III 307..466 CDD:299850 33/205 (16%)
CYCc 833..1060 CDD:214485 58/234 (25%)
Nucleotidyl_cyc_III 861..1085 CDD:299850 59/233 (25%)
gcy-12NP_494995.2 PBP1_Speract_GC_like 123..545 CDD:107365 45/298 (15%)
ANF_receptor 140..519 CDD:279440 43/272 (16%)
PK_GC-A_B 648..957 CDD:270944 75/422 (18%)
TyrKc 688..951 CDD:197581 66/372 (18%)
HNOBA <967..1012 CDD:285003 13/57 (23%)
CYCc 991..1183 CDD:214485 61/249 (24%)
Guanylate_cyc 1018..1206 CDD:278633 59/235 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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