Protein Alignment ACXC and Gucy2c

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_001120790.1
• Gene: Gucy2c / 14917
• MGIID: 106903
• Length: 1072
• Species: Mus musculus
• Alignment Length: 1046
• Identity: 208/1046 - (19%)
• Similarity: 375/1046 - (35%)
• Gaps: 337/1046 - (32%)

  Fly   298 MGPRTTESFMAIQIHPDVSILYADV--------VNYTHLTTTLTVGNLVKVLHDLYGRFDIAASN 354
            |||..|  :...|::.|..:.|..:        .:|.. |.|..:....|:::.|...:.:..::
Mouse   120 MGPSCT--YSTFQMYLDTELNYPMISAGSYGLSCDYKE-TLTRILPPARKLMYFLVDFWKVNNAS 181

  Fly   355 FKVQRIKFLGDCYYCVAGLTTPDPDHAKC-----CVSLGISMIS---NIQEV--RAERGLDIDMR 409
            ||    .|..:..|.....:.|:    .|     .:..|:|..|   |.::|  |:|:..:|  .
Mouse   182 FK----PFSWNSSYVYKNGSEPE----DCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEI--L 236

  Fly   410 IGVHSGSLLAGIIGEAKLQFDIWGTDVEIA------------NHL--ESTGEPGYVHVSGRTLSM 460
            .|.:..|.:..:.|..:..:|:.| |:::|            ||.  |:|..|.|:   ...|.:
Mouse   237 TGHNRKSNVIVMCGTPESFYDVKG-DLQVAEDTVVILVDLFSNHYFEENTTAPEYM---DNVLVL 297

  Fly   461 LNPADYTILSGTQKAQ------SDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRI 519
            ..|::.: .|.|..|:      ||..|.|:...||.|.:. ::|:.:
Mouse   298 TLPSEQS-TSNTSVAERFSSGRSDFSLAYLEGTLLFGHML-QTFLEN------------------ 342

  Fly   520 RSSRPSQSSMTDEFREEFRNMPVGG---------------------INLNSPCCRRTRL----DT 559
                 .::....:|...|||:...|                     ::|::   |:.::    ||
Mouse   343 -----GENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDT---RKYKVLMKYDT 399

  Fly   560 HKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLL--AWGIGCCLIYIQIVTNNFSCTACIV 622
            ||.....:.                ..|:||:|:..|.  ..|:|..::.|.:    |:.|..:|
Mouse   400 HKNKTIPVA----------------ENPNFIWKNHKLPNDVPGLGPQILMIAV----FTLTGILV 444

  Fly   623 VDLVTFFFLTSLLCLAWYKNVCWWKSGRYEF----RIYGKYSCMAFHIFEKI------------- 670
            |     ..|.:||.|..|:.....:..::..    .|:...:....||..||
Mouse   445 V-----LLLIALLVLRKYRRDHALRQKKWSHIPSENIFPLETNETNHISLKIDDDRRRDTIQRVR 504

  Fly   671 -----QHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELS------YIESKIY---HY----- 716
                 :..|.|:...:....||....|.|..| ...|.|.|:      .::::|:   .|
Mouse   505 QCKYDKKKVILKDLKHSDGNFSEKQKIDLNKL-LQSDYYNLTKFYGTVKLDTRIFGVVEYCERGS 568

  Fly   717 --EMDRDTCFHP------WVFTNMI--SLILGISYTF-ARIPFGLKIVISCCETLAYLLIVFFQF 770
              |:..||..:|      |.|...:  .:..|:||.. ::|....::..:.|...:.:::....|
Mouse   569 LREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDF 633

  Fly   771 A------------FIFQHSATTTPFMKAELAHCLRVCMMLL----TMYA----KERQSEFNTKMN 815
            .            ...:|....|...|.::.....:...::    |.|.    ...:..|..:.:
Mouse   634 GCNSILPPKKDLWTAPEHLRQATISQKGDVYSFAIIAQEIILRKETFYTLSCRDHNEKIFRVENS 698

  Fly   816 Y----------------KLNVDL-------QNKQKAADLTN-QSIIILLNNILPSHVVDLYLNSL 856
            |                :|.|.|       ::.:|..|... :|.:..:..:......:.|:::|
Mouse   699 YGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTL 763

  Fly   857 AKH-ELYYEN---------------------------------------------YRMVSVMFAM 875
            .:. :||..|                                             |..|::.|:.
Mouse   764 IRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSD 828

  Fly   876 LINF--------PMNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASN 932
            ::.|        ||.:  :.:||||...||:::    :::.|.|::.:|..|:.|.||.
Mouse   829 IVGFTTICKYSTPMEV--VDMLNDIYKSFDQIV----DHHDVYKVETIGDAYVVASGLP------ 881

  Fly   933 IRQTDHFRNSSLH-VEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSF 996
                  .||.:.| |::              |.|..|.:.|| .||.|:.:..|....|
Mouse   882 ------MRNGNRHAVDI--------------SKMALDILSFI-GTFELEHLPGLPVWIR------ 919

  Fly   997 FERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQE 1061
                       ||:.||...|||||...|.|.::|:.||.||||||||||..|.::..:..||:.
Mouse   920 -----------IGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKR 973

  Fly  1062 FDIKCIY--RGMTFVKGRGDIPTYFV-GI-DENLKFMSAKLVNRSLSRRFSVMSSLDPDSLRKSS 1122
            .|.:.:|  ||.|::||||...||:: |: |:.....|...|... .|..:..|.:...:|:|..
Mouse   974 TDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPSPPTVENQ-QRLQTEFSDMIVSALQKRQ 1037

  Fly  1123 SSDQES 1128
            :|.::|
Mouse  1038 ASGKKS 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	37/190 (19%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	74/279 (27%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_type1	35..415	CDD:471960	65/355 (18%)
		Protein Kinases, catalytic domain	480..749	CDD:473864	41/269 (15%)
		CYCc	787..978	CDD:214485	61/240 (25%)