DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gucy2f

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	360	Identity:	81/360 - (22%)
Similarity:	160/360 - (44%)	Gaps:	91/360 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 FRIMN--------DTMVRASFLDRHQFIMEETWLRHALLQESI------------LLDSILPPQI 274
            |:::|        |:|:|  .|:::...:|:      |::|..            ||..:|||.:
Zfish   810 FKLINKGKKTNIIDSMLR--MLEQYSSNLED------LIRERTEELEVEKQRTEKLLSEMLPPSV 866

  Fly   275 AKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVK 339
            |:.::       |.:...|:.|.                .|:|.::|:|.:|.:::......:|.
Zfish   867 AEALK-------TGASVEPEYFD----------------QVTIYFSDIVGFTTISSLSDPIEVVD 908

  Fly   340 VLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPD-HAKCCVSLGISMISNIQ--EVRAE 401
            :|:|||..||....:..|.:::.:||.|...:||...:.: ||....::.::::|::.  ::|..
Zfish   909 LLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKHAAEIANMSLNILSSVGSFKMRHM 973

  Fly   402 RGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPAD- 465
            ..:.:.:|||:|||..:||::|....::.::|..|..|:.:||||.|..:||:..|:.:|...:
Zfish   974 PEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNISTVQILRSLND 1038

  Fly   466 -YTI-LSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSVLEVKSIDRIRSSRPSQSS 528
             |.| :.|..:.:...:.:   ||.|.|              :::....:.:...|:.....|..
Zfish  1039 GYKIDVRGKTELKGKGIEE---TYWLVG--------------KANFTKPLPNPPEIKPGDNWQDM 1086

  Fly   529 MTDEFREEFR--NMPVGGINLNSPCCRRTRLDTHK 561
            ||:|.:..||  |.||               |.||
Zfish  1087 MTEEIKSLFRKANRPV---------------DKHK 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	15/74 (20%)
		CYCc	293..468	CDD:214485	46/179 (26%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	43/163 (26%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..816	CDD:270945	2/5 (40%)
		HNOBA	<825..870	CDD:311573	12/52 (23%)
		CYCc	850..1042	CDD:214485	53/214 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900