DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXC and Npr2

DIOPT Version :9

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:NP_446290.1 Gene:Npr2 / 116564 RGDID:620851 Length:1047 Species:Rattus norvegicus


Alignment Length:485 Identity:103/485 - (21%)
Similarity:197/485 - (40%) Gaps:132/485 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 LTIELLY-VQHYNAVFFNFVIRVVSTIL-------------------VLTVLSINFCEKF----- 115
            ||.::|: ::|...|.||.:.|.:...:                   :|...|||....|     
  Rat   560 LTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLI 624

  Fly   116 --------------VSRHRWVMIASSVL-SVYLVVLTDIVMISYH-----------FYKNDW--- 151
                          :|.|..:..::.|: |.:::.:||..:.|:.           :.|..|   
  Rat   625 NDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAP 689

  Fly   152 ------PLNTS----FDVFTLCMIYMFLPIPS----IKGAAL----LASSVSLIYVAFFMHSLTF 198
                  ||.|:    .||::..:|...:.:.|    ::|..|    :...|......:|..|:  
  Rat   690 ELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSI-- 752

  Fly   199 NAVYTDRDSFGYDVI-------STDILHNLGFNMMGIFFR---------IMNDTMVR-ASFLDRH 246
                 ||.....:::       :.|......|..:..|.|         |:::.::| ..:.:..
  Rat   753 -----DRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNL 812

  Fly   247 QFIMEETWLRHALLQE----SILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFM 307
            :.::||.  ..|.|:|    ..||..|||..:|:.::   :.:..|:|                 
  Rat   813 EKLVEER--TQAYLEEKRKAEALLYQILPHSVAEQLK---RGETVQAE----------------- 855

  Fly   308 AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAG 372
               ....|:|.::|:|.:|.|:...|...:|.:|:|||..||....||.|.:::.:||.|..|:|
  Rat   856 ---AFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSG 917

  Fly   373 LTTPD-----PDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIW 432
            |...:     |:.|:..::| :..:|:.: :|......:.:|||||:|.:.||::|....::.::
  Rat   918 LPGRNGQRHAPEIARMALAL-LDAVSSFR-IRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980

  Fly   433 GTDVEIANHLESTGEPGYVHVSGRTLSMLN 462
            |..|..|:.:||.|:...:|||..|...|:
  Rat   981 GDTVNTASRMESNGQALKIHVSSTTKDALD 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 AC_N <33..285 CDD:292831 53/301 (18%)
CYCc 293..468 CDD:214485 48/175 (27%)
Nucleotidyl_cyc_III 307..466 CDD:299850 48/161 (30%)
CYCc 833..1060 CDD:214485
Nucleotidyl_cyc_III 861..1085 CDD:299850
Npr2NP_446290.1 PBP1_NPR_B 26..421 CDD:380607
PK_GC-A_B 518..792 CDD:270944 40/238 (17%)
HNOBA <798..846 CDD:400168 12/49 (24%)
CYCc 825..1009 CDD:214485 56/208 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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