Protein Alignment ACXC and Adcy9

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_011244107.1
• Gene: Adcy9 / 11515
• MGIID: 108450
• Length: 1372
• Species: Mus musculus
• Alignment Length: 1358
• Identity: 322/1358 - (23%)
• Similarity: 526/1358 - (38%)
• Gaps: 440/1358 - (32%)

  Fly     4 PRTNSRKSPLKRKRLRPCHLDYANERLWEHSY----LREKCKEL---NLEEEYRYYQVRLMVSNL 61
            ||.......|:|::..|...:.|:.|.|:..:    |.|.|.|.   ..:..:||
Mouse    64 PRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSMNLEEACLERCFPQTQRRFRY---------- 118

  Fly    62 TIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINF---C--------EKF 115
            .:|||.|..|..|      :|          |.:.:.|.::|:.|.::.|   |        .|.
Mouse   119 ALFYVGFACLLWS------IY----------FAVHMKSKVIVMVVPALCFLVVCVGFFLFTFTKL 167

  Fly   116 VSRH-RWVMIASSVLSVYLVVLTDIVMISYHFYKNDW-PLNTSFD-------------------V 159
            .:|| .|..:|.::| |:.:.|.....:        | ||:...|                   .
Mouse   168 YARHYAWTSLALTLL-VFALTLAAQFQV--------WTPLSGRVDSSNHTLTATPADTCLSQVGS 223

  Fly   160 FTLC-----MIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGY--------- 210
            |::|     ::|..:.:|              :|::.|: .:.::.::   ::|||
Mouse   224 FSICIEVLLLLYTVMQLP--------------LYLSLFL-GVVYSVLF---ETFGYHFRNEDCYP 270

  Fly   211 ---------DVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILL 266
                     :::|..:|| :..:.:||...:|:....|::||...|.||....|......:..::
Mouse   271 SPGPGALHWELLSRALLH-VCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMI 334

  Fly   267 DSILPPQIAKPVQEKIKSKITQSENSPDR--------------FQMGPRTTESFMAIQIHPDVSI 317
            .|::|..||   .:.:|....:||||..|              .|..|.....|...||. :|||
Mouse   335 HSVMPRIIA---DDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIE-EVSI 395

  Fly   318 LYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAK 382
            |:||:|.:|.::...:...||.:|:||:||||......|.::|..||||||||||...|..|||.
Mouse   396 LFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAY 460

  Fly   383 CCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGE 447
            ||:.:|:.||..|::...|:...::||:|||:|::|.||:|..:.:||:|..||.:||.:|..|.
Mouse   461 CCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGV 525

  Fly   448 PGYVHVSGRTLSMLNPADYTILSGT------QKAQSDPVLQYIHTYLLTGQVARESFI------- 499
            .|.||:|..|...|:.. |.:..|.      |...:|. |:.:.|||::||.|:||..
Mouse   526 AGKVHISEATAKYLDDR-YEMEDGRVIERLGQSVVADQ-LKGLKTYLISGQRAKESHCSCAEALL 588

  Fly   500 -------------------TSIGGVRSSSVLEVKSIDRIRSSRPS------------------QS 527
                               |:..|..|.....||:.|.:::. ||                  |:
Mouse   589 SGFEVIDDSRESSGPRGQGTASPGSVSDLAQTVKTFDNLKTC-PSCGITFAPKSEAGAEGGTVQN 652

  Fly   528 SMTDEFREE---------FRNMPV--------GGIN------LNSP------------CCR---- 553
            ...||.:..         |.::|:        ||.|      |.||            .|.
Mouse   653 GCQDEPKTSTKVTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQE 717

  Fly   554 ----------------------RTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQP-------DF 589
                                  |.:.|.|         |....|:.||..:|..:|       :|
Mouse   718 KGRWAGVSLDQSALLPLRFKNIREKTDAH---------FVDVIKEDSLMKDYFFKPPINQFSLNF 773

  Fly   590 I-------FKSSMLLAWGIGCCLIYIQIVTNN------FSCTACIVVDL---VTFFFLTSLLCLA 638
            :       :::|            |.:.|..|      .|.|...::|:   .|.|.:.|:.|
Mouse   774 LDQELERSYRTS------------YQEEVIKNSPVKTFASATFSSLLDVFLSTTVFLILSITC-- 824

  Fly   639 WYKNVCWWKSGRYEFRIYGKYSC----MAFHIF------EKIQHSVSLRITVYLGILFSYYAVIS 693
                          |..||..:.    .|..:|      |.:...||:|:..:|.
Mouse   825 --------------FLKYGATATPPPPAALAVFGADLLLEVLSLIVSIRMVFFLE---------- 865

  Fly   694 LIMLNCDRDMYE---------------LSYIESKIY-HYEMDRDTCFHPWVFTNMISLILGISY- 741
             .::.|.:.:.|               :|.....:| |...:.:|..|..:||....|:..:.|
Mouse   866 -DVMTCTKWLLEWIAGWLPRHCIGAILVSLPALAVYSHITSEFETNIHVTMFTGSAVLVAVVHYC 929

  Fly   742 TFAR------------IPFGLKIV--ISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAH-- 790
            .|.:            :..||.::  ||.|:..:   ||..........||...|...:.|..
Mouse   930 NFCQLSSWMRSSLATIVGAGLLLLLHISLCQDSS---IVMSPLDSAQNFSAQRNPCNSSVLQDGR 991

  Fly   791 ----------CLRVCMMLLTMYAKERQSEFNTKMNYKLNVD-------LQNKQKAADLTNQSIII 838
                      .|...::||.::...|:.|.:.:::|..:|:       :|:.:..||.
Mouse   992 RPASLIGKELILTFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADW------- 1049

  Fly   839 LLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFAMLINFPM--------NLPSLRVLNDIITQ 895
            ||.||:|.||.:    .|...:.|.:|:....|:||.::||..        .....||||::|..
Mouse  1050 LLRNIIPYHVAE----QLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGD 1110

  Fly   896 FDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDEN 960
            ||.||:. .:|..:||||.:|.|||||.||               |::...|..|.:.|
Mouse  1111 FDELLSK-PDYNSIEKIKTIGATYMAASGL---------------NTAQCQEGGHPQEH------ 1153

  Fly   961 YDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQP 1025
                      :.|:..||.::||.:...|.......|       |:.:|.:.|.:.|||:|.::.
Mouse  1154 ----------LRILFEFAKEMMRVVDDFNNNMLWFNF-------KLRVGFNHGPLTAGVIGTTKL 1201

  Fly  1026 HYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTY 1083
            .|||||:.||:||||::||:...|||:|||.::|.:......|||...|||:|.:.||
Mouse  1202 LYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	58/313 (19%)
		CYCc	293..468	CDD:214485	72/188 (38%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	67/158 (42%)
		CYCc	833..1060	CDD:214485	74/234 (32%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	76/231 (33%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	24/152 (16%)
		Guanylate_cyc	385..573	CDD:306677	76/190 (40%)
		Guanylate_cyc	1069..1260	CDD:306677	76/230 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810