DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy7

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_006530643.1	Gene:	Adcy7 / 11513	MGIID:	102891	Length:	1146	Species:	Mus musculus

Alignment Length:	1240	Identity:	325/1240 - (26%)
Similarity:	525/1240 - (42%)	Gaps:	300/1240 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LEEEYRYYQVR-------LMVSNLTIFYVLFI------------ILAMSFLTIELLYVQHYNAVF 90
            |.|:||...:.       |:|:..|...::.|            :|..:||.: .|:|..|..|:
Mouse    21 LYEKYRLTSLHGPLLLLLLLVAAATCIALISIAFSHEDLRRHQVVLGTAFLML-TLFVALYVLVY 84

  Fly    91 FNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKND---WP 152
            ...:::                       ||:...:.:....|:||..::|  :...:|:   |.
Mouse    85 VECLVQ-----------------------RWLRALALLTWACLMVLGSVLM--WDSLENEAHAWE 124

  Fly   153 LNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAV----YTDRDS--FGYD 211
             ...|.:|.:.::|..||:.  :.||::|...|.:     .|.|.|.||    .|...|  .|..
Mouse   125 -QVPFFLFVVFVVYALLPLS--RRAAIVAGVTSTV-----SHLLVFGAVTRAFQTSMSSTQLGLQ 181

  Fly   212 VISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAK 276
            :::..:: .||.|..|.|.:.......|..|:...:.|.....||....|:..||.|:||..|:.
Mouse   182 LLANAVI-LLGGNFTGAFHKHQLQDASRDLFIYTVKCIQIRRKLRVEKRQQENLLLSVLPAHISM 245

  Fly   277 PVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVL 341
            .::..|   |.:.:...||..| |......:.::.|.:|||||||:|.:|.|.:..:...||.||
Mouse   246 GMKLAI---IERLKEGGDRHYM-PDNNFHSLYVKRHQNVSILYADIVGFTRLASDCSPKELVVVL 306

  Fly   342 HDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDI 406
            ::|:|:||..|...:..|||.||||||||:||....|.||:.||.:|:.:...|::||...|:||
Mouse   307 NELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQVREATGVDI 371

  Fly   407 DMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSG 471
            .||:|:|||::|.|:||..|.|:|:|..||.:||.:|:.|.||.||::..||:.|:.| |.:..|
Mouse   372 SMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLNHLDKA-YEVEDG 435

  Fly   472 TQKAQSDPVLQ--YIHTYL--------------------------LTGQVARESFITSIGGVR-- 506
             ...|.||.|:  .|.|||                          :...|....::.|.|..|
Mouse   436 -HGEQRDPYLKEMNIRTYLVIDPRSQQPPPPSHHLSKPKGDATLKMRASVRVTRYLESWGAARPF 499

  Fly   507 ---------SSSVLEV------KSIDRIRSSRPSQSS-----MTDEFREEFRNMPVGGINLNSPC 551
                     |||...:      |:|...|...|.:|:     :.|:..:|..: .:.|::...||
Mouse   500 AHLNHRESVSSSETPISNGRRQKAIPLRRHRAPDRSASPKGRLEDDCDDEMLS-AIEGLSSTRPC 563

  Fly   552 CRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQP------DFIFKSSMLLAWGIGCCLIYIQI 610
            |.::. |.|        .|...|.:...|..|...|      ||...|.:.:      |::.:.:
Mouse   564 CSKSD-DFH--------TFGPIFLEKGFEREYRLVPIPRARYDFACASLVFV------CILLVHL 613

  Fly   611 VTN--------NFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEF-RIYGKYSCMAFHI 666
            :..        :|...||::..:::|.|.|                   || |.:...|.:. .|
Mouse   614 LVMPRMATLGVSFGLVACLLGLVLSFCFAT-------------------EFSRCFPSRSTLQ-AI 658

  Fly   667 FEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTN 731
            .|.::....:|:.:   ::.:..:::::.::|....:..         ..|...|....|....|
Mouse   659 SESVETQPLVRLVL---VVLTVGSLLTVAIINMPLTLNP---------GPEQPGDNKTSPLAAQN 711

  Fly   732 MI------------SLILGI--SYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTT- 781
            .:            |.|||.  ...|.|:...||.::.....:||||:  |..:..:..|..:|
Mouse   712 RVGTPCELLPYYTCSCILGFIACSVFLRMSLELKAMLLTVALVAYLLL--FNLSPCWHVSGNSTE 774

  Fly   782 ---------------------------------PFMKAELAHCLRVCMMLLTMYAK----ERQSE 809
                                             .:::.:|.  :.|...|:..||.    .||.:
Mouse   775 TNGTQRTRLLLSDAQSMPSHTLAPGARETAPSPSYLERDLK--IMVNFYLILFYATLILLSRQID 837

  Fly   810 FNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMFA 874
            :..:::.......:.:.:..:.......:||.|:||:||...::...|..:.|:::|..|.||||
Mouse   838 YYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIGDKAAEDWYHQSYDCVCVMFA 902

  Fly   875 MLINFPM----------NLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNL 929
            .:.:|.:          .|..||:||:||..||.||.. .::..|||||.:|.|||||.||.
Mouse   903 SVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLK-PKFSGVEKIKTIGSTYMAAAGLS--- 963

  Fly   930 ASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSS 994
            |.:..:........:|:.|                         :..|::.||..|...||...:
Mouse   964 APSGHENQDLERKHVHIGV-------------------------LVEFSMALMSKLDGINRHSFN 1003

  Fly   995 SFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL 1059
            ||        ::.:||:.|.::|||:||.:|.||||||.||:||||||||..|.||||||:..||
Mouse  1004 SF--------RLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTIL 1060

  Fly  1060 QEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKFMSAKL----VNRSLSRRFSVMSSLDPDSLRK 1120
            |.....|..||:..|||:|::.|||     .|.|::..:    |:.||.||    .||..||  .
Mouse  1061 QGLGYSCECRGLINVKGKGELRTYF-----ELFFLNPSVGQGFVSGSLLRR----PSLTTDS--N 1114

  Fly  1121 SSSSD 1125
            :.|||
Mouse  1115 TPSSD 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	58/267 (22%)
		CYCc	293..468	CDD:214485	78/174 (45%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	73/158 (46%)
		CYCc	833..1060	CDD:214485	84/236 (36%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	87/233 (37%)
Adcy7	XP_006530643.1	AC_N	<75..251	CDD:318454	46/209 (22%)
		Guanylate_cyc	272..422	CDD:306677	69/149 (46%)
		DUF1053	487..593	CDD:399378	24/115 (21%)
		Guanylate_cyc	890..1085	CDD:306677	86/231 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870