DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy6

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_006520366.3	Gene:	Adcy6 / 11512	MGIID:	87917	Length:	1254	Species:	Mus musculus

Alignment Length:	1191	Identity:	309/1191 - (25%)
Similarity:	519/1191 - (43%)	Gaps:	245/1191 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRTNSRKSPLKRKRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRLMVSNLTIFYVLF 68
            |.|:.|..|....||             ...:..::.:...||..|:.|..::..|:||:...:.
Mouse   194 PDTSPRSGPSCWHRL-------------VQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVL 245

  Fly    69 IILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFV--SRHRWVMIASSVLSV 131
            ::|....||......|...|.           :.:||..|:.|....|  :||.:...:..|:|.
Mouse   246 VLLMAVLLTFHAAPAQPQPAY-----------VALLTCASVLFVVLMVVCNRHSFRQDSMWVVSY 299

  Fly   132 YLVVLTDIVMISYHFYKNDWPLNTS----FDVFTLCMIYMFLPIPSIKGAALLASSVSLIY--VA 190
            .::.:...|.:......|  |.:.|    ..||.:.:.|..||| .::.|.|....:|.::  :|
Mouse   300 VVLGILAAVQVGGALAAN--PHSPSAGLWCPVFFVYITYTLLPI-RMRAAVLSGLGLSTLHLILA 361

  Fly   191 FFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWL 255
            :.::|         .|.|.:..:..:::..|..|.:|:......:...|.:|.:...:|.....|
Mouse   362 WQLNS---------SDPFLWKQLGANVVLFLCTNAIGVCTHYPAEVSQRQAFQETRGYIQARLHL 417

  Fly   256 RHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFM----AIQIHPDVS 316
            :|...|:..||.|:||..:|..::|.|.:|                 .|..|    .||.|.:||
Mouse   418 QHENRQQERLLLSVLPQHVAMEMKEDINTK-----------------KEDMMFHKIYIQKHDNVS 465

  Fly   317 ILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHA 381
            ||:||:..:|.|.:..|...||..|::|:.|||..|:.....|||.||||||||:||.....|||
Mouse   466 ILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 530

  Fly   382 KCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTG 446
            .|||.:|:.||..|..||...|::::||:|:|||.:..|::|..|.|||:|..||.:|||:|:.|
Mouse   531 HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG 595

  Fly   447 EPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVL--QYIHTYLLTG--QVARE--SFITSIGGV 505
            ..|.:|::..||..|| .||.:..| :..:.:..|  |.|.|:|:.|  |..:|  :.:..:...
Mouse   596 RAGRIHITRATLQYLN-GDYEVEPG-RGGERNAYLKEQCIETFLILGASQKRKEEKAMLAKLQRT 658

  Fly   506 RSSSV----------------LEVKSI------DRIRSSRPSQSSMTDEFR-EEFRNMPVGGINL 547
            |::|:                .:.|:.      |..:.:|.:|.::..|.. :||....:...::
Mouse   659 RANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDNRGAQDALNPEDEVDEFLGRAIDARSI 723

  Fly   548 NSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVT 612
            :     :.|.|..::       |...|:...||..|..:.|..|.:.:..|..:.|.:.:||::.
Mouse   724 D-----QLRKDHVRR-------FLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLV 776

  Fly   613 NNFSCTACIVVDLVTFFFL----TSLLCLAWYKNVCWWKSGRYEFRIYGKYSCMAF--------- 664
            ..:|   .:::.:....||    |.|:|.     ||               ||.:|
Mouse   777 FPYS---TLILGIYAAIFLLLLVTVLICA-----VC---------------SCGSFFPKALQRLS 818

  Fly   665 -HIFEKIQHSVSLRITVYLGILFSYYAVISLIMLN------CDRDMYELSYIESKIYH-----YE 717
             :|.....||.::.|...|.:..|  |:.::...|      |...|..|:..:....|     |.
Mouse   819 RNIVRSRVHSTAVGIFSVLLVFIS--AIANMFTCNHTPIRTCAARMLNLTPADVTACHLQQLNYS 881

  Fly   718 MDRD---------TCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYL-LIVFFQFAF 772
            :..|         ||..|..|...:.|.|..|..|..|....|:.::......|| |::....|.
Mouse   882 LGLDAPLCEGTAPTCSFPEYFVGNVLLSLLASSVFLHISSIGKLAMTFILGFTYLVLLLLGPPAA 946

  Fly   773 IFQH-----------SATTT------PFM-KAELAHCLRVCMML--LTMYAKERQSEFNTKMNYK 817
            ||.:           |:..|      |.: :..|.:...|.:::  |.:|...:|.|...::::.
Mouse   947 IFDNYDLLLGVHGLASSNETFDGLDCPAVGRVALKYMTPVILLVFALALYLHAQQVESTARLDFL 1011

  Fly   818 LNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINFP- 880
            ..:....:::..:........||:||||..|...:| ......||||::...|:||||.:.||.
Mouse  1012 WKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSE 1076

  Fly   881 ---------MNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQT 936
                     ..:..||:||:||..||.:::..| :..:||||.:|.|||||.||
Mouse  1077 FYVELEANNEGVECLRLLNEIIADFDEIISEER-FRQLEKIKTIGSTYMAASGL----------- 1129

  Fly   937 DHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSL 1001
                |:|.:.:|  .|:|                :..:..:|:.||..:...|        |.|.
Mouse  1130 ----NASTYDQV--GRSH----------------ITALADYAMRLMEQMKHIN--------EHSF 1164

  Fly  1002 SQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKIL--QEFDI 1064
            :..::.||::.|.::|||:||.:|.||||||.||::|||:|||:|..||||.:..::|  :.:.:
Mouse  1165 NNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQL 1229

  Fly  1065 KCIYRGMTFVKGRGDIPTYFV 1085
            :|  ||:..|||:|::.|||:
Mouse  1230 EC--RGVVKVKGKGEMTTYFL 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	55/259 (21%)
		CYCc	293..468	CDD:214485	76/178 (43%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	73/162 (45%)
		CYCc	833..1060	CDD:214485	80/239 (33%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	80/235 (34%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454	64/312 (21%)
		Guanylate_cyc	456..640	CDD:306677	80/185 (43%)
		DUF1053	668..754	CDD:368844	15/97 (15%)
		Guanylate_cyc	1056..1250	CDD:306677	81/237 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910