Protein Alignment ACXC and ADCY9

DIOPT Version :9

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: XP_005255136.1
• Gene: ADCY9 / 115
• HGNCID: 240
• Length: 1372
• Species: Homo sapiens
• Alignment Length: 1323
• Identity: 315/1323 - (23%)
• Similarity: 517/1323 - (39%)
• Gaps: 370/1323 - (27%)

  Fly     4 PRTNSRKSPLKRKRLRPCHLDYANERLWEHSY----LREKCKEL---NLEEEYRYYQVRLMVSNL 61
            ||.......|:|::..|...:.|:.|.|:..:    |.|.|.|.   ..:..:||
Human    64 PRRVGGGGRLRRQKKLPQLFERASSRWWDPKFDSVNLEEACLERCFPQTQRRFRY---------- 118

  Fly    62 TIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRH-RWVMIA 125
            .:||:.|..|..|     :.:..|..:.....|...:..:||.....:....|..:|| .|..:|
Human   119 ALFYIGFACLLWS-----IYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLA 178

  Fly   126 SSVLSVYLVVLTDIVMI--------SYHFYKNDWPLNTSFD---VFTLCMIYMFLPIPSIKGAAL 179
            .::|...|.:.....::        |.:......|.:|...   .|::|:..:||....:.....
Human   179 LTLLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLY 243

  Fly   180 LASSVSLIYVAFFMHSLTFNAVYTDRDSF--------GYDVISTDILHNLGFNMMGIFFRIMNDT 236
            |:..:.:.|...|.   ||...:.|...|        .::::|..:||.. .:.:|:...:|:..
Human   244 LSLCLGVAYSVLFE---TFGYHFRDEACFPSPGAGALHWELLSRGLLHGC-IHAIGVHLFVMSQV 304

  Fly   237 MVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDR------ 295
            ..|::||...|.||....|......:..::.|::|..||   .:.:|....:||||..|
Human   305 RSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIA---DDLMKQGDEESENSVKRHATSSP 366

  Fly   296 --------FQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAA 352
                    .|..|.....|...||. :||||:||:|.:|.::...:...||.:|:||:||||...
Human   367 KNRKKKSSIQKAPIAFRPFKMQQIE-EVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLC 430

  Fly   353 SNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSL 417
            ...|.::|..||||||||||...|..|||.||:.:|:.||..|::...|:...::||:|||:|::
Human   431 EETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTV 495

  Fly   418 LAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGT------QKAQ 476
            |.||:|..:.:||:|..||.:||.:|..|..|.||:|..|...|:.. |.:..|.      |...
Human   496 LCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDR-YEMEDGKVIERLGQSVV 559

  Fly   477 SDPVLQYIHTYLLTGQVARESFI--------------------------TSIGGVRSSSVLEVKS 515
            :|. |:.:.|||::||.|:||..                          |:..|..|.....||:
Human   560 ADQ-LKGLKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGNVSDLAQTVKT 623

  Fly   516 IDRIRSSRPS------------------QSSMTDEFREE---------FRNMPV--------GGI 545
            .|.:::. ||                  |:...||.:..         |.::|:        ||.
Human   624 FDNLKTC-PSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSSWLLFLSVPLLAHPPKASGGP 687

  Fly   546 N------LNSP------------CCR--------------------------RTRLDTHKKTQRE 566
            |      |.||            .|.                          |.:.|.|
Human   688 NPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALLPLRFKNIREKTDAH------ 746

  Fly   567 IGIFCAAFKDSSLEWNYLHQP-------DFI-------FKSSMLLAWGIGCCLIYIQIVTNN--- 614
               |....|:.||..:|..:|       :|:       :::|            |.:.|..|
Human   747 ---FVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTS------------YQEEVIKNSPV 796

  Fly   615 -------FSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYE----------FRIYGKYSCM 662
                   ||  :.:.|.|.|..|||       ....|:.|   ||          ..::.
Human   797 KTFASPTFS--SLLDVFLSTTVFLT-------LSTTCFLK---YEAATVPPPPAALAVFS----- 844

  Fly   663 AFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYE---------------LSYIESK 712
            |..:.|.:..:||:|:..:|..:.:           |.:.:.|               :|.....
Human   845 AALLLEVLSLAVSIRMVFFLEDVMA-----------CTKRLLEWIAGWLPRHCIGAILVSLPALA 898

  Fly   713 IY-HYEMDRDTCFHPWVFTNMISLILGISY-TFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQ 775
            :| |...:.:|..|..|||...:||..:.| .|.::...::..::.......||:::  .:....
Human   899 VYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLY--VSLCPD 961

  Fly   776 HSATTTPF-----MKAELAHC--------------------LRVCMMLLTMYAKERQSEFNTKMN 815
            .|..|:|.     ..:|...|                    |...::||.::...|:.|.:.:::
Human   962 SSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLH 1026

  Fly   816 YKLNVD-------LQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHELYYENYRMVSVMF 873
            |..:|:       :|:.:..||.       ||.||:|.||.:    .|...:.|.:|:....|:|
Human  1027 YHGDVEADLHRTKIQSMRDQADW-------LLRNIIPYHVAE----QLKVSQTYSKNHDSGGVIF 1080

  Fly   874 AMLINFPM--------NLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLA 930
            |.::||..        .....||||::|..||.||:. .:|..:||||.:|.|||||.||
Human  1081 ASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSK-PDYSSIEKIKTIGATYMAASGL----- 1139

  Fly   931 SNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSS 995
                      |::...:..|.:.|                :.|:..||.::||.:...|......
Human  1140 ----------NTAQAQDGSHPQEH----------------LQILFEFAKEMMRVVDDFNNNMLWF 1178

  Fly   996 FFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQ 1060
            .|       |:.:|.:.|.:.|||:|.::..|||||:.||:||||::||:...|||:|||.::|.
Human  1179 NF-------KLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLS 1236

  Fly  1061 EFDIKCIYRGMTFVKGRGDIPTY 1083
            :......|||...|||:|.:.||
Human  1237 KMGYDFDYRGTVNVKGKGQMKTY 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	53/278 (19%)
		CYCc	293..468	CDD:214485	72/188 (38%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	67/158 (42%)
		CYCc	833..1060	CDD:214485	73/234 (31%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	75/231 (32%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	35/201 (17%)
		CYCc	326..544	CDD:214485	80/222 (36%)
		Guanylate_cyc	385..573	CDD:278633	76/190 (40%)
		CYCc	1043..1243	CDD:214485	76/249 (31%)
		Guanylate_cyc	1069..1260	CDD:278633	75/230 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810