DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXC and ADCY8

DIOPT Version :10

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:1160 Identity:334/1160 - (28%)
Similarity:516/1160 - (44%) Gaps:216/1160 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 HLDYA--NERLW---EHSY-------LREKCKELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMS 74
            |||.|  |...:   .:||       ||...|..:||..|:.|.:.....:..:..||.::..::
Human   131 HLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLT 195

  Fly    75 FLTIELLY----VQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVV 135
            .|.:.|..    :.....:...|...:...|..|.|:     .|..:.|.::..:..|  .::.:
Human   196 LLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVV-----RKDTTSHTYLQYSGVV--TWVAM 253

  Fly   136 LTDIVM--ISYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAF-----FM 193
            .|.|:.  :.|....:    ...:.:|||...|..||:| :..|.|.....||:.|..     .:
Human   254 TTQILAAGLGYGLLGD----GIGYVLFTLFATYSMLPLP-LTWAILAGLGTSLLQVILQVVIPRL 313

  Fly   194 HSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRHA 258
            ..::.|.|......|            :..|..|||...::|...|.:||:..:.:.....|...
Human   314 AVISINQVVAQAVLF------------MCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETE 366

  Fly   259 LLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIH--PDVSILYAD 321
            ..::..|:.|:||..:   |.|.| :.:|..|:...:.|        |..|.||  .:||||:||
Human   367 NQRQERLVLSVLPRFV---VLEMI-NDMTNVEDEHLQHQ--------FHRIYIHRYENVSILFAD 419

  Fly   322 VVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVS 386
            |..:|:|:|||:...||::|::|:.|||..|......|||.||||||||:||..|..|||.|||.
Human   420 VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVE 484

  Fly   387 LGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYV 451
            :|:|||..|:.||:....|:|||||:||||:|.|::|..|.|||:|..||:|||.|||.|.||.:
Human   485 MGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRI 549

  Fly   452 HVSGRTLSMLNPADYTILSGTQKAQSDPVLQY-IHTYL----------LTGQVARESFITSIGGV 505
            |:|..||..|| .||.:..|..|.:::.:.:: |.|||          |...:.:|| ::|....
Human   550 HISKATLDCLN-GDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKES-VSSSDRR 612

  Fly   506 RSSSVLEVKS------IDRIRSSRPSQSSMTDEFREEFRNMP----------VGGINLNSPCCRR 554
            .|.:.....|      .|.|...:.:.:::|   |.....:|          .|...:|......
Human   613 NSGATFTEGSWSPELPFDNIVGKQNTLAALT---RNSINLLPNHLAQALHVQSGPEEINKRIEHT 674

  Fly   555 TRLDTHKKTQRE-IGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIV------- 611
            ..|.:..|.:|| |..|...|||||||..|....|.:|||:::.|:.:   |::|..:       
Human   675 IDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV---LLFITAIQSLLPSS 736

  Fly   612 -----TNNFSCTACIVVDLVTFFFLTSLLCLAW-YKNVCWWKSGRYEFRIYGKYSCMAFHIFEKI 670
                 |..||....:...||.........||.. .:..|.|.:..|                   
Human   737 RVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETY------------------- 782

  Fly   671 QHSVSLRITVYLGILFSYYAVISLIMLNCDRD----MYELSYIESKIYHYEMDRDTCFHP--WVF 729
               ::..:.::..||.::...| |.:|.||.|    :..|::..|.::     .|.|.:|  :||
Human   783 ---LARNVIIFASILINFLGAI-LNILWCDFDKSIPLKNLTFNSSAVF-----TDICSYPEYFVF 838

  Fly   730 TNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAFIF------QHSATTTPFMKAEL 788
            |.:::::  ....|.|:...||:.:.......|.|:....:|.:|      .||.  ..|:..:.
Human   839 TGVLAMV--TCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSG--EDFLGTKE 899

  Fly   789 AHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQ---NKQKAADLTNQSIIILLNNILPSHVVD 850
            ...|.:.|.||.::...:|.|:..::::...|..:   |:.|.....|::   :|.|||||||..
Human   900 VSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNEN---MLRNILPSHVAR 961

  Fly   851 LYL-NSLAKHELYYENYRMVSVMFAMLINF-------PMN---LPSLRVLNDIITQFDRLLTAYR 904
            .:| ......|||.::|..|.||||.:..|       .||   :..||:||:||..||.||...|
Human   962 HFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDR 1026

  Fly   905 EYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDE 969
             :..:||||.:|.||||..||                |....:.|....|               
Human  1027 -FQDIEKIKTIGSTYMAVSGL----------------SPEKQQCEDKWGH--------------- 1059

  Fly   970 VVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPV 1034
             :..:..|:|.|..::...|: :|.:.||       :.||||.|.::|||:||.:|.|||||..|
Human  1060 -LCALADFSLALTESIQEINK-HSFNNFE-------LRIGISHGSVVAGVIGAKKPQYDIWGKTV 1115

  Fly  1035 NMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKG----RGDIPTYFV 1085
            |:||||:|||:.|.|||.||:..||::......|||..:|||    .|.|.|||:
Human  1116 NLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 Nucleotidyl_cyc_III 307..466 CDD:448371 85/160 (53%)
Nucleotidyl_cyc_III 861..1085 CDD:448371 86/237 (36%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182 14/50 (28%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AcyC 214..567 CDD:441717 132/389 (34%)
Guanylate_cyc 405..589 CDD:425528 93/184 (51%)
Adcy_cons_dom 617..712 CDD:461877 23/97 (24%)
Guanylate_cyc 973..1172 CDD:425528 87/239 (36%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 32/62 (52%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.

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