Protein Alignment ACXC and ADCY6

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_056085.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Alignment Length: 1153
• Identity: 297/1153 - (25%)
• Similarity: 498/1153 - (43%)
• Gaps: 230/1153 - (19%)

  Fly    41 KELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLT 105
            :...||..|:.|..::..|:||:...:.::|....|.......:...|     .:.:::....|.
Human   132 RSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPA-----YVALLACAAALF 191

  Fly   106 VLSINFCEK--FVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTS----FDVFTLCM 164
            |..:..|.:  |.....|| ::..||.:...|.....:.:.       |.:.|    ..||.:.:
Human   192 VGLMVVCNRHSFRQDSMWV-VSYVVLGILAAVQVGGALAAD-------PRSPSAGLWCPVFFVYI 248

  Fly   165 IYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDR-DSFGYDVISTDILHNLGFNMMGI 228
            .|..||| .::.|.|....:|.:::..        |...:| |:|.:..:..::|..|..|::||
Human   249 AYTLLPI-RMRAAVLSGLGLSTLHLIL--------AWQLNRGDAFLWKQLGANVLLFLCTNVIGI 304

  Fly   229 FFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSP 293
            ......:...|.:|.:...:|.....|:|...|:..||.|:||..:|..::|.|.:|
Human   305 CTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK-------- 361

  Fly   294 DRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASN 354
                     .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..|:.
Human   362 ---------KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 417

  Fly   355 FKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLA 419
            ....|||.||||||||:||.....|||.|||.:|:.||..|..||...|::::||:|:|||.:..
Human   418 NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHC 482

  Fly   420 GIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVL--Q 482
            |::|..|.|||:|..||.:|||:|:.|..|.:|::..||..|| .||.:..| :..:.:..|  |
Human   483 GVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN-GDYEVEPG-RGGERNAYLKEQ 545

  Fly   483 YIHTYLLTG--QVARE--SFITSIGGVRSSSV-------LEVKSIDRIRSSRPSQSSMTDEFREE 536
            :|.|:|:.|  |..:|  :.:..:...|::|:       :..::..|.:.|:            .
Human   546 HIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSK------------A 598

  Fly   537 FRNMPVGGINLNSPCCRRTR---------------------LDTHKKTQREIGIFCAAFKDSSLE 580
            ||.|   ||:.:|...|.|:                     :|..:|.  .:..|...|:...||
Human   599 FRQM---GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKD--HVRRFLLTFQREDLE 658

  Fly   581 WNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTAC-IVVDLVTFFFLTSLLCLAWYKNVC 644
            ..|..:.|..|.:.:..|..:.|.:.:||::....|.... |...:.....:|.|:|..
Human   659 KKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAV------ 717

  Fly   645 WWKSGRYEFRIYGKYSCMAF--HIFEKIQHSV------SLRITVYLGILFSYYAVISLIMLN--- 698
                          |||.:.  ...:::..|:      |..:.::..:|....|:.::...|
Human   718 --------------YSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTP 768

  Fly   699 ---CDRDMYELSYIESKIYH-----YEMDRD---------TCFHPWVFTNMISLILGISYTFARI 746
               |...|..|:..:....|     |.:..|         ||..|..|...:.|.|..|..|..|
Human   769 IRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHI 833

  Fly   747 PFGLKIVISCCETLAYL-LIVFFQFAFIFQH----------SATTTPFMKAELAHCLRVCMMLLT 800
            ....|:.:.....|.|| |::....|.||.:          :::...|...:.....||.:..:|
Human   834 SSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMT 898

  Fly   801 ----------MYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYL-N 854
                      :|...:|.|...::::...:....:::..:........||:||||..|...:| .
Human   899 PVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLAR 963

  Fly   855 SLAKHELYYENYRMVSVMFAMLINFP----------MNLPSLRVLNDIITQFDRLLTAYREYYVV 909
            .....||||::...|:||||.:.||.          ..:..||:||:||..||.:::..| :..:
Human   964 ERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEER-FRQL 1027

  Fly   910 EKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIM 974
            ||||.:|.|||||.||               |:|.:.:|  .|:|                :..:
Human  1028 EKIKTIGSTYMAASGL---------------NASTYDQV--GRSH----------------ITAL 1059

  Fly   975 TTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASR 1039
            ..:|:.||..:...|        |.|.:..::.||::.|.::|||:||.:|.||||||.||::||
Human  1060 ADYAMRLMEQMKHIN--------EHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSR 1116

  Fly  1040 MESTGLPGHIQVTEESAKIL--QEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            |:|||:|..||||.:..::|  :.:.::|  ||:..|||:|::.|||:
Human  1117 MDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	73/162 (45%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	80/235 (34%)
ADCY6	NP_056085.1	AC_N	<16..368	CDD:318454	56/274 (20%)
		Guanylate_cyc	370..554	CDD:425528	80/185 (43%)
		Adcy_cons_dom	582..669	CDD:461877	18/103 (17%)
		Guanylate_cyc	970..1164	CDD:425528	81/237 (34%)