DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXC and ADCY6

DIOPT Version :9

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:NP_001377760.1 Gene:ADCY6 / 112 HGNCID:237 Length:1168 Species:Homo sapiens


Alignment Length:1153 Identity:297/1153 - (25%)
Similarity:498/1153 - (43%) Gaps:230/1153 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 KELNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLT 105
            :...||..|:.|..::..|:||:...:.::|....|.......:...|     .:.:::....|.
Human   132 RSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPA-----YVALLACAAALF 191

  Fly   106 VLSINFCEK--FVSRHRWVMIASSVLSVYLVVLTDIVMISYHFYKNDWPLNTS----FDVFTLCM 164
            |..:..|.:  |.....|| ::..||.:...|.....:.:.       |.:.|    ..||.:.:
Human   192 VGLMVVCNRHSFRQDSMWV-VSYVVLGILAAVQVGGALAAD-------PRSPSAGLWCPVFFVYI 248

  Fly   165 IYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDR-DSFGYDVISTDILHNLGFNMMGI 228
            .|..||| .::.|.|....:|.:::..        |...:| |:|.:..:..::|..|..|::||
Human   249 AYTLLPI-RMRAAVLSGLGLSTLHLIL--------AWQLNRGDAFLWKQLGANVLLFLCTNVIGI 304

  Fly   229 FFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSP 293
            ......:...|.:|.:...:|.....|:|...|:..||.|:||..:|..::|.|.:|        
Human   305 CTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTK-------- 361

  Fly   294 DRFQMGPRTTESFM----AIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASN 354
                     .|..|    .||.|.:||||:||:..:|.|.:..|...||..|::|:.|||..|:.
Human   362 ---------KEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAE 417

  Fly   355 FKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLA 419
            ....|||.||||||||:||.....|||.|||.:|:.||..|..||...|::::||:|:|||.:..
Human   418 NHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHC 482

  Fly   420 GIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVL--Q 482
            |::|..|.|||:|..||.:|||:|:.|..|.:|::..||..|| .||.:..| :..:.:..|  |
Human   483 GVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLN-GDYEVEPG-RGGERNAYLKEQ 545

  Fly   483 YIHTYLLTG--QVARE--SFITSIGGVRSSSV-------LEVKSIDRIRSSRPSQSSMTDEFREE 536
            :|.|:|:.|  |..:|  :.:..:...|::|:       :..::..|.:.|:            .
Human   546 HIETFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAFSRTKDSK------------A 598

  Fly   537 FRNMPVGGINLNSPCCRRTR---------------------LDTHKKTQREIGIFCAAFKDSSLE 580
            ||.|   ||:.:|...|.|:                     :|..:|.  .:..|...|:...||
Human   599 FRQM---GIDDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKD--HVRRFLLTFQREDLE 658

  Fly   581 WNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTAC-IVVDLVTFFFLTSLLCLAWYKNVC 644
            ..|..:.|..|.:.:..|..:.|.:.:||::....|.... |...:.....:|.|:|..      
Human   659 KKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAV------ 717

  Fly   645 WWKSGRYEFRIYGKYSCMAF--HIFEKIQHSV------SLRITVYLGILFSYYAVISLIMLN--- 698
                          |||.:.  ...:::..|:      |..:.::..:|....|:.::...|   
Human   718 --------------YSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTP 768

  Fly   699 ---CDRDMYELSYIESKIYH-----YEMDRD---------TCFHPWVFTNMISLILGISYTFARI 746
               |...|..|:..:....|     |.:..|         ||..|..|...:.|.|..|..|..|
Human   769 IRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHI 833

  Fly   747 PFGLKIVISCCETLAYL-LIVFFQFAFIFQH----------SATTTPFMKAELAHCLRVCMMLLT 800
            ....|:.:.....|.|| |::....|.||.:          :::...|...:.....||.:..:|
Human   834 SSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMT 898

  Fly   801 ----------MYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYL-N 854
                      :|...:|.|...::::...:....:::..:........||:||||..|...:| .
Human   899 PVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLAR 963

  Fly   855 SLAKHELYYENYRMVSVMFAMLINFP----------MNLPSLRVLNDIITQFDRLLTAYREYYVV 909
            .....||||::...|:||||.:.||.          ..:..||:||:||..||.:::..| :..:
Human   964 ERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEER-FRQL 1027

  Fly   910 EKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIM 974
            ||||.:|.|||||.||               |:|.:.:|  .|:|                :..:
Human  1028 EKIKTIGSTYMAASGL---------------NASTYDQV--GRSH----------------ITAL 1059

  Fly   975 TTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASR 1039
            ..:|:.||..:...|        |.|.:..::.||::.|.::|||:||.:|.||||||.||::||
Human  1060 ADYAMRLMEQMKHIN--------EHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSR 1116

  Fly  1040 MESTGLPGHIQVTEESAKIL--QEFDIKCIYRGMTFVKGRGDIPTYFV 1085
            |:|||:|..||||.:..::|  :.:.::|  ||:..|||:|::.|||:
Human  1117 MDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTTYFL 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 AC_N <33..285 CDD:292831 53/250 (21%)
CYCc 293..468 CDD:214485 76/178 (43%)
Nucleotidyl_cyc_III 307..466 CDD:299850 73/162 (45%)
CYCc 833..1060 CDD:214485 80/239 (33%)
Nucleotidyl_cyc_III 861..1085 CDD:299850 80/235 (34%)
ADCY6NP_001377760.1 AC_N <16..368 CDD:318454 56/274 (20%)
Guanylate_cyc 370..554 CDD:306677 80/185 (43%)
DUF1053 582..668 CDD:399378 18/102 (18%)
Guanylate_cyc 970..1164 CDD:306677 81/237 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45627
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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