DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXC and ADCY3

DIOPT Version :9

Sequence 1:NP_609593.1 Gene:ACXC / 34689 FlyBaseID:FBgn0040508 Length:1130 Species:Drosophila melanogaster
Sequence 2:XP_011530791.1 Gene:ADCY3 / 109 HGNCID:234 Length:1186 Species:Homo sapiens


Alignment Length:1268 Identity:316/1268 - (24%)
Similarity:518/1268 - (40%) Gaps:376/1268 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 NLEEEYRYYQVR-----LMVSNLTIFYVLF-----IILAMSFLTIELLYVQHYNAVFFNFVIRVV 98
            :||..|:.|..|     |:|  |.:|..||     ::.|:.|.:.:|.            .:.|.
Human    61 SLENLYQTYFKRQRHETLLV--LVVFAALFDCYVVVMCAVVFSSDKLA------------SLAVA 111

  Fly    99 STILVLTVLSINFCEKFVSRHR----------WVMIASSVLSVYLVVLTDIVMISYHFYKNDWPL 153
            ...|||.::....|:|.:...|          |::|.:.:.| ||         ..:|.:.....
Human   112 GIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFS-YL---------GLNFARAHAAS 166

  Fly   154 NT-SFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFN---AVYTDRDSFGYDVIS 214
            :| .:.||.:...::.||:.       |:..|.:..|:..:|:|...   |.....:..|..:: 
Human   167 DTVGWQVFFVFSFFITLPLS-------LSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLL- 223

  Fly   215 TDILHNLGFNM----MGIFFRIMNDTMVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIA 275
            .:||.|:...:    :||....|.|...|.:||:..|.:..:..|.....|:..|:.||||..:|
Human   224 REILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVA 288

  Fly   276 KPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKV 340
            ..:.:.:|    :.|:..|:.|.      :.|.:..|.:||||:||:|.:|.|::..:...|||:
Human   289 DEMLKDMK----KDESQKDQQQF------NTMYMYRHENVSILFADIVGFTQLSSACSAQELVKL 343

  Fly   341 LHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLD 405
            |::|:.|||..|:.:...|||.|||||||:.||.....|||.|.:.:|::|:..|..||.:....
Human   344 LNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTG 408

  Fly   406 IDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPG--------------------- 449
            :|||:|||:|::|.|::|:.:.|:|:|.|||.:||.:|:.|.||                     
Human   409 VDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGGSKIEERLYSCVVAPTLRLRW 473

  Fly   450 -YVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY-IHTYLLTG---QVARESFITSIGG----- 504
             .||:|..|:..|. .::.:..|...::.|.:.:. |.|||:..   :|.:.:....:.|     
Human   474 ERVHISQSTMDCLK-GEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPN 537

  Fly   505 -----VRSSS--VLEVKSIDRIRSSRPSQSSMTDE-----FREEFRNMP----VGGINLNSPCC- 552
                 .:|||  ::|.|..:....|..|.|...:|     |.....::|    :.|...::|.. 
Human   538 GAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTLSHLPHSRCLPGSQADNPSFP 602

  Fly   553 ---RRTRL------------DTHKKTQ-----------------REIGIFCAAFKDSSLEWNYLH 585
               ||.||            |.|:..|                 |...:....|.|..:|..|..
Human   603 NPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSV 667

  Fly   586 QPDFIFKSSMLLAWGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYK-NVCWWKSG 649
            :.:   |.|       |..          ||| :|:|           |||.|..: .:..|...
Human   668 EKE---KQS-------GAA----------FSC-SCVV-----------LLCTALVEILIDPWLMT 700

  Fly   650 RYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIY 714
            .|                          :|..:|      .::.||:..|     .|:.|..:.:
Human   701 NY--------------------------VTFMVG------EILLLILTIC-----SLAAIFPRAF 728

  Fly   715 HYEMDRDTCFHPW-------------------VFTNMISLILGISYTF--ARIPFGLKIVISCCE 758
            ..::   ..|..|                   |..|::.::..:.|..  :....|::...||.|
Human   729 PKKL---VAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLE 790

  Fly   759 TLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLT----------------------- 800
            ...|     :.:..:....||   .|..:::|.:::.:|||.                       
Human   791 NPKY-----YNYVAVLSLIAT---IMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKR 847

  Fly   801 -------MYAKERQSEFNTKMN------------------------------------------Y 816
                   |.|.|:...||..:|                                          :
Human   848 FREHDLPMVALEQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLW 912

  Fly   817 KLNVDLQNKQKAADLT--NQSIIILLNNILPSHVVDLYLNSLAK-HELYYENYRMVSVMFAMLIN 878
            |:.|..| |::..::.  |::   |:.|:||.||...:|.|..: .|||.:.|..:.||||.|.|
Human   913 KIEVHDQ-KERVYEMRRWNEA---LVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPN 973

  Fly   879 F-------PMN---LPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGL--DFNLAS 931
            |       .:|   :..||.||:||:.||.||. ..::.|:.|||.:|.|||||.|:  |.|   
Human   974 FADFYTEESINNGGIECLRFLNEIISDFDSLLD-NPKFRVITKIKTIGSTYMAASGVTPDVN--- 1034

  Fly   932 NIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSF 996
                |:.|.:|:...:.|..|...:.|               :..|||.:..||...|....::|
Human  1035 ----TNGFASSNKEDKSERERWQHLAD---------------LADFALAMKDTLTNINNQSFNNF 1080

  Fly   997 FERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQE 1061
            ..|        ||::.|.::|||:||.:||||||||.||:||||||||:.|:|||.||:..||:|
Human  1081 MLR--------IGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILRE 1137

  Fly  1062 FDIKCIYRGMTFVKGRGDIPTYFV-GIDENLKF 1093
            :..:.:.||..||||:|::.|:|: |.|:...|
Human  1138 YGFRFVRRGPIFVKGKGELLTFFLKGRDKLATF 1170

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXCNP_609593.1 AC_N <33..285 CDD:292831 59/268 (22%)
CYCc 293..468 CDD:214485 70/196 (36%)
Nucleotidyl_cyc_III 307..466 CDD:299850 68/180 (38%)
CYCc 833..1060 CDD:214485 91/239 (38%)
Nucleotidyl_cyc_III 861..1085 CDD:299850 91/235 (39%)
ADCY3XP_011530791.1 AC_N <44..303 CDD:292831 60/277 (22%)
CYCc 273..490 CDD:214485 79/227 (35%)
Guanylate_cyc 310..516 CDD:278633 74/206 (36%)
CYCc 925..1143 CDD:214485 93/251 (37%)
Guanylate_cyc 956..1163 CDD:278633 92/237 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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