DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and ADCY2

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	1182	Identity:	324/1182 - (27%)
Similarity:	533/1182 - (45%)	Gaps:	202/1182 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LWEHS-----YLREKCKE-------LNLEEEYRYYQVRLMVSNLTIFYVLFIILAMSFLTIELLY 82
            :|:.:     |||::.:|       |....::.|.....|.....:  ::|::|.:....:.||
Human     1 MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPL--IVFLLLIVMGSCLALL- 62

  Fly    83 VQHYNAVFFNFVI----RVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVY--------LVV 135
                 ||||...:    .|...|.|.|.|:|.|.         :.|...:.||:        ||:
Human    63 -----AVFFALGLEVEDHVAFLITVPTALAIFFA---------IFILVCIESVFKKLLRLFSLVI 113

  Fly   136 LTDIVMISYHFY-----KNDWPLNTSFDVFTLCMIYMFLPI---PSIKGAALLASSVSLIYVAFF 192
            ...:|.:.|.|.     .:.|. ..||.:|.:.::|..||.   .:|..:.|.:||.:::.
Human   114 WICLVAMGYLFMCFGGTVSPWD-QVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVL---- 173

  Fly   193 MHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDRHQFIMEETWLRH 257
              |:..:|....::...:.:::..|:...| |:.|.:.:.:.:..::.::.|....|.....|..
Human   174 --SVCLSATPGGKEHLVWQILANVIIFICG-NLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEF 235

  Fly   258 ALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESF--MAIQIHPDVSILYA 320
            ...|:..||.|:||..||.    ::|::|.|....|...||  ..|.:|  :.::.|.:||||||
Human   236 EKRQQERLLLSLLPAHIAM----EMKAEIIQRLQGPKAGQM--ENTNNFHNLYVKRHTNVSILYA 294

  Fly   321 DVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCV 385
            |:|.:|.|.:..:.|.||.:|::|:|:||..|...:..|||.||||||||:||....|:|||.||
Human   295 DIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCV 359

  Fly   386 SLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGY 450
            .:|:.|...|::||...|:||:||:|||||::|.|:||..|.|:|:|..||.:|||:|:.|.||.
Human   360 KMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGR 424

  Fly   451 VHVSGRTLSMLNPADYTILSGTQKAQSDPVLQ--YIHTYLL---TGQVARESFI-----TSIGGV 505
            ||:|..||..||.| |.:..|....: ||.|:  .:.||.:   .|:......:     |..|..
Human   425 VHISSVTLEHLNGA-YKVEEGDGDIR-DPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAK 487

  Fly   506 RSSSVLEVKSIDRIRSSRP-----SQSSMTDE-FREEFRNMPVGGINLNSPCCRRTRLDTHKK-- 562
            ..:||...:.::...:::|     .:.|||.| .:....::|:|..|..:   |..|..:.||
Human   488 MRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQN---RTLRTKSQKKRF 549

  Fly   563 ----------------------TQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCL 605
                                  ...:|......|.:..||..|.......||..:..|..|..|:
Human   550 EEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCI 614

  Fly   606 IYIQIVTNNFSCTACIVVDLVTFFFLTSLL---CLAWYKNVCWWKSGRYEFRIYGKYSCMAFHIF 667
            ..:||:.  ...|:.:.:.....|.|.:.:   |.|.....|..|:......:......:|...:
Human   615 FIVQILV--LPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPW 677

  Fly   668 EKIQHSVSLRITVYLGILFSYYAVISLIML-----------NCDRDMYELSYIESKIYHYEMDRD 721
            .:|.      :|:....:....||.::..|           |.....:..|..:..|...:   :
Human   678 PRIS------LTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQ---N 733

  Fly   722 TCFHPWVFTNMISLILGI--SYTFARIPFGLKIVISCCETLAYLLIVFFQFAFI---FQHSATTT 781
            ..|.|:.   :.|.|||:  ...|.|:.:.||::|.....:.|..|:....|.:   :.......
Human   734 LFFLPYF---IYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFER 795

  Fly   782 PFMKAEL--AHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNIL 844
            |.:..:|  ...:.:.:..:|:....||:|:..::::......:.:::..:.......:||.|:|
Human   796 PGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVL 860

  Fly   845 PSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINF----------PMNLPSLRVLNDIITQFDR 898
            |:||.:.:| .||...|||:::|..|.||||.:.:|          ...|..||:||:||..||.
Human   861 PAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDD 925

  Fly   899 LLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDS 963
            ||:. .::..|||||.:|.|||||.||     |.:...:|.:      |.|....|
Human   926 LLSK-PKFSGVEKIKTIGSTYMAATGL-----SAVPSQEHSQ------EPERQYMH--------- 969

  Fly   964 DMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYD 1028
                   :..|..||..|:..|.|.|:        .|.:..|:.:||:.|.::|||:||.:|.||
Human   970 -------IGTMVEFAFALVGKLDAINK--------HSFNDFKLRVGINHGPVIAGVIGAQKPQYD 1019

  Fly  1029 IWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFVGIDENLKF 1093
            ||||.||:||||:|||:...||||||::.:||.....|..||:..|||:||:.||||..:
Human  1020 IWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTE----- 1079

  Fly  1094 MSAKLVNRSLSR 1105
                 ::||||:
Human  1080 -----MSRSLSQ 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	59/283 (21%)
		CYCc	293..468	CDD:214485	85/176 (48%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	79/158 (50%)
		CYCc	833..1060	CDD:214485	88/237 (37%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	89/233 (38%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	54/255 (21%)
		CYCc	236..439	CDD:214485	95/209 (45%)
		Guanylate_cyc	281..465	CDD:278633	86/185 (46%)
		DUF1053	495..599	CDD:283888	17/106 (16%)
		CYCc	848..1056	CDD:214485	90/243 (37%)
		Guanylate_cyc	878..1077	CDD:278633	90/234 (38%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		7/16 (44%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880