DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and ADCY1

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_066939.1	Gene:	ADCY1 / 107	HGNCID:	232	Length:	1119	Species:	Homo sapiens

Alignment Length:	1192	Identity:	307/1192 - (25%)
Similarity:	500/1192 - (41%)	Gaps:	286/1192 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KRKRLRPCHLDYANERLWEHSYLREKCKELNLEEEYRYYQVRL-MVSNLTIFYVLFIILAMSFLT 77
            :|:.||.|..::|             |.|  ||..:|.|.:|| ..:.|....|| .:||.:...
Human    29 RRRGLRACDEEFA-------------CPE--LEALFRGYTLRLEQAATLKALAVL-SLLAGALAL 77

  Fly    78 IELLYV----------QHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVY 132
            .|||..          .|           .|..:|.|.:|                :.::|.|:.
Human    78 AELLGAPGPAPGLAKGSH-----------PVHCVLFLALL----------------VVTNVRSLQ 115

  Fly   133 LVVLTDIVMISYHFYKN---------------------DWPLNTSFDVFTLCMI----YMFLPIP 172
            :..|..:..::..|...                     ..|......|:.|.::    |..||:.
Human   116 VPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR 180

  Fly   173 SIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTM 237
            |     |||....|:..|  .|.|....:...:....:..:..:.|..:|.||.|:|.||:.:..
Human   181 S-----LLAIGFGLVVAA--SHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERS 238

  Fly   238 VRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRT 302
            .|.:||.....|.:...|.....::..||.|:||..:|..::|.              |...|..
Human   239 QRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED--------------FLKPPER 289

  Fly   303 TESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCY 367
            ....:.||.|.:||||:||:|.:|.|.:..|...|||:|::|:|:||..|:....:|||.|||||
Human   290 IFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCY 354

  Fly   368 YCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIW 432
            |||:|||.|..|||.|||.:|:.||..|..|.....:|::||:|:|:|.:|.|::|..|.|:|:|
Human   355 YCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVW 419

  Fly   433 GTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY-IHTYLLTGQVARE 496
            ..||.:||.:|:.|.||.||::..||:.|| .||.:..|....::..:..: |.|:.:.....|:
Human   420 SNDVTLANVMEAAGLPGKVHITKTTLACLN-GDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRK 483

  Fly   497 SFITSI-GGVRSSSVLEVKSI-----------DRIRSSRPSQSSMT---DEFR-------EEFRN 539
            .|...| ..::.:..::.|::           ...::..|..:.||   |:.|       |:.||
Human   484 IFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRN 548

  Fly   540 MPVGGINL--NSPCCR----RTRLDTHKKTQRE---IGIFCAAFKDSSLEWNYLHQPDFIFKSSM 595
            ......|:  .:|..|    .:||...::|:.|   :..|...:|....|..|....|..|.|::
Human   549 RSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAV 613

  Fly   596 LLA------WGIGCCLIYIQIVTNNFSCTACI--VVDLVTFFFLTSLLCLAWYKNVCWWKSGRYE 652
            :|.      :|:...||:.|.|........||  :|..|.:..:|.:.|..
Human   614 VLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFP-------------- 664

  Fly   653 FRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSYIESKIYHYE 717
                   .|:          ::.:|..:.:.|:...|:|....::.|
Human   665 -------GCL----------TIQIRTVLCIFIVVLIYSVAQGCVVGC------------------ 694

  Fly   718 MDRDTCFHPWVFT---NMISLILGISYTFARIPF----GLKIVISCCETLAYLLIVFFQFA---- 771
                   .||.::   |...::|........:|.    .....:.||......|.:||:.:
Human   695 -------LPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPK 752

  Fly   772 FIFQHSATTTPFMKAELAHCLR--------------VCMML----LTMYAKERQSEFNTKMNYKL 818
            .|.....||:..:..||:...|              |.::|    |.::|  ||.:...:::|..
Human   753 MILLSGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHA--RQVDIRLRLDYLW 815

  Fly   819 NVDLQNKQKAAD---LTNQSIIILLNNILPSHVVDLYLNSLAKH-ELYYENYRMVSVMFAMLINF 879
            ....:.:::..:   |.|:.|:.   |:||:||...:|.|..:: :|||::|..|.||||.:.||
Human   816 AAQAEEEREDMEKVKLDNRRILF---NLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNF 877

  Fly   880 ----------PMNLPSLRVLNDIITQFDRLLTAYREYYV-VEKIKVVGCTYMAACGLDFNLASNI 933
                      .|.:..||:||:||..||.|:.  :::|. :||||.:|.|||||.||     :..
Human   878 NDFYIELDGNNMGVECLRLLNEIIADFDELME--KDFYKDIEKIKTIGSTYMAAVGL-----APT 935

  Fly   934 RQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFE 998
            ..|...::.|.|:..                         :..||:::...|...|....:.|..
Human   936 SGTKAKKSISSHLST-------------------------LADFAIEMFDVLDEINYQSYNDFVL 975

  Fly   999 RSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFD 1063
            |        :||:.|.::|||:||.:|.||||||.||:||||:|||:.|.||||||..::|:...
Human   976 R--------VGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032

  Fly  1064 IKCIYRGMTFVKGRGDIPTYFV 1085
            ...:.||...|||:|::.|||:
Human  1033 YHFVCRGKVSVKGKGEMLTYFL 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	59/287 (21%)
		CYCc	293..468	CDD:214485	79/174 (45%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	75/158 (47%)
		CYCc	833..1060	CDD:214485	83/238 (35%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	83/234 (35%)
ADCY1	NP_066939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		AC_N	<161..292	CDD:292831	35/151 (23%)
		CYCc	258..453	CDD:214485	85/209 (41%)
		Guanylate_cyc	294..476	CDD:278633	80/182 (44%)
		Interaction with calmodulin. /evidence=ECO:0000250	493..520		1/26 (4%)
		CYCc	826..1037	CDD:214485	85/253 (34%)
		Guanylate_cyc	859..1056	CDD:278633	84/236 (36%)
		Interaction with calmodulin. /evidence=ECO:0000250	1024..1047		6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810