Protein Alignment ACXC and Adcy3

DIOPT Version :10

• Sequence 1: NP_609593.1
• Gene: ACXC / 34689
• FlyBaseID: FBgn0040508
• Length: 1130
• Species: Drosophila melanogaster
• Sequence 2: NP_612178.2
• Gene: Adcy3 / 104111
• MGIID: 99675
• Length: 1145
• Species: Mus musculus
• Alignment Length: 1221
• Identity: 322/1221 - (26%)
• Similarity: 532/1221 - (43%)
• Gaps: 311/1221 - (25%)

  Fly    44 NLEEEYRYYQVR-----LMVSNLTIFYVLF-----IILAMSFLTIELLYVQHYNAVFFNFVIRVV 98
            :||..|:.|..|     |:|  |.:|..||     ::.|:.|.:.:|.            .:.|.
Mouse    61 SLENLYQTYFKRQRHETLLV--LVVFAALFDCYVVVMCAVVFSSDKLA------------PLMVA 111

  Fly    99 STILVLTVLSINFCEKFVSRHR----------WVMIASSVLSVYLVV-------LTDIVMISYHF 146
            ...|||.::....|:|.:...|          |::|::.:.| ||.:       .:|.|
Mouse   112 GFGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLISAQIFS-YLGLNFSRAHAASDTV------ 169

  Fly   147 YKNDWPLNTSFDVFTLCMIYMFLPIPSIKGAALLASSVSLIYVAFFMHSLTFNAVYT--DRDSFG 209
               .|   .:|.||:     .|:.:|......::.|.||.:     :|:|.......  .:|...
Mouse   170 ---GW---QAFFVFS-----FFITLPLSLSPIVIISVVSCV-----VHTLVLGVTVAQQQQDELE 218

  Fly   210 YDVISTDILHNLGFNMMGIFFRIMN----DTMVRASFLDRHQFIMEETWLRHALLQESILLDSIL 270
            ...:..:||.|:...:..|...||:    |...|.:||:..|.:..:..|.....|:..|:.|||
Mouse   219 GMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSIL 283

  Fly   271 PPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVG 335
            |..:|..:.:.:|    :.|:..|:.|.      :.|.:..|.:||||:||:|.:|.|::..:..
Mouse   284 PKHVADEMLKDMK----KDESQKDQQQF------NTMYMYRHENVSILFADIVGFTQLSSACSAQ 338

  Fly   336 NLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRA 400
            .|||:|::|:.|||..|:.:...|||.|||||||:.||.....|||.|.:.:|::|:..|..||.
Mouse   339 ELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVRE 403

  Fly   401 ERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLNPAD 465
            :....:|||:|||:|::|.|::|:.:.|:|:|.|||.:||.:|:.|.||.||:|..|:..|. .:
Mouse   404 KTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLK-GE 467

  Fly   466 YTILSGTQKAQSDPVLQY-IHTYLLTGQVARESFI--TSIGGVRSSSVLEVKSIDRIRSSRPSQ- 526
            :.:..|...::.|.:.:. |.|||:   :|.:..:  |:..|:..|:|..    ....||:||.
Mouse   468 FDVEPGDGGSRCDYLDEKGIETYLI---IASKPEVKKTAQNGLNGSAVPN----GAPASSKPSSP 525

  Fly   527 --------------SSMTDEFREEFRNMPVGGINLNSPCCRRTRL------------DTHKKTQ- 564
                          |..|.|..|| :.......:..:| .||.||            |.|:..|
Mouse   526 ALIETKEPNGSAHASGSTSEEAEE-QEAQADNPSFPNP-RRRLRLQDLADRVVDASEDEHELNQL 588

  Fly   565 ----------------REIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIYIQIVTN 613
                            |...:....|.|..:|..|..:.:   |.|. .|:...|.:::
Mouse   589 LNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKE---KQSG-AAFSCSCVVLF------ 643

  Fly   614 NFSCTACI--------VVDLVTFFFLTSLLCL----------------------AWYKNVCWWKS 648
               |||.:        :.:.|||.....||.:                      :|.....|.::
Mouse   644 ---CTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRSFPKKLVAFSSWIDRTRWARN 705

  Fly   649 GRYEFRIY--------GKYSCMAFHIFEKIQHSVSLRITVYLGIL-----FSYYAVISL---IML 697
            ......|:        ...||:.:::.   .::::..:.:..|.:     ::|.||:||   |||
Mouse   706 TWAMLAIFILVMANVVDMLSCLQYYMG---PYNMTAGMELDGGCMENPKYYNYVAVLSLIATIML 767

  Fly   698 NCDRDMYELS--------------YIESKIY-HYE----MDRDTCFHPWVFTNMISLIL--GISY 741
            .....|.:|:              |....:: .|:    .::|:   |.|....:.::.  |::.
Mouse   768 VQVSHMVKLTLMLLVTGAVTALNLYAWCPVFDEYDHKRFQEKDS---PMVALEKMQVLATPGLNG 829

  Fly   742 TFARIPFGLKIVISCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKER 806
            |.:|:|    :|.|                   ::|.|...|            :|:|:.|...|
Mouse   830 TDSRLP----LVPS-------------------KYSMTVMMF------------VMMLSFYYFSR 859

  Fly   807 QSE--FNTKMNYKLNVDLQNKQKAADLT--NQSIIILLNNILPSHVVDLYLNSLAK-HELYYENY 866
            ..|  ..|...:|:.|..| |::..::.  |::   |:.|:||.||...:|.|..: .|||.::|
Mouse   860 HVEKLARTLFLWKIEVHDQ-KERVYEMRRWNEA---LVTNMLPEHVARHFLGSKKRDEELYSQSY 920

  Fly   867 RMVSVMFAMLINF-------PMN---LPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMA 921
            ..:.||||.|.||       .:|   :..||.||:||:.||.||. ..::.|:.|||.:|.||||
Mouse   921 DEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLD-NPKFRVITKIKTIGSTYMA 984

  Fly   922 ACGL--DFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRT 984
            |.|:  |.|       |:.|.:||...:.:..|...:.|               :..|||.:..|
Mouse   985 ASGVTPDVN-------TNGFTSSSKEEKSDKERWQHLAD---------------LADFALAMKDT 1027

  Fly   985 LAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHI 1049
            |...|....::|..|        ||::.|.::|||:||.:||||||||.||:||||||||:.|:|
Mouse  1028 LTNINNQSFNNFMLR--------IGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNI 1084

  Fly  1050 QVTEESAKILQEFDIKCIYRGMTFVKGRGDIPTYFV-GIDENLKFMSAKLV 1099
            ||.||:..||:|:..:.:.||..||||:|::.|:|: |.|....|.:...|
Mouse  1085 QVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSV 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	Nucleotidyl_cyc_III	307..466	CDD:448371	68/158 (43%)
		Nucleotidyl_cyc_III	861..1085	CDD:448371	91/235 (39%)
Adcy3	NP_612178.2	AcyC	105..499	CDD:441717	125/442 (28%)
		Guanylate_cyc	310..494	CDD:425528	74/187 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	504..564		13/65 (20%)
		Guanylate_cyc	915..1122	CDD:425528	92/237 (39%)