DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and Adcy4

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001348533.1	Gene:	Adcy4 / 104110	MGIID:	99674	Length:	1077	Species:	Mus musculus

Alignment Length:	1185	Identity:	321/1185 - (27%)
Similarity:	521/1185 - (43%)	Gaps:	284/1185 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YY----QVRLMVSNLTIFYVLFIILAM---------------SFLTIELLYVQHYNAVFFNFVIR 96
            ||    |..|::  |.:..||..::|:               ||||..|..:..::
Mouse    20 YYSLSQQYPLLI--LLLVIVLCALVALPAVAWASGRELTSDPSFLTTVLCALGGFS--------- 73

  Fly    97 VVSTILVLTVLSINFCEKFVSRHRWVMIASSVLSVYLVVLTDIVMISYHF-----YKNDWPLNTS 156
                      |.:....:.....||....|.::.|.|:.|      .|.|     ..:.|. ..|
Mouse    74 ----------LLLGLASREQQLQRWTRPLSGLIWVALLAL------GYGFLFTGGVVSAWD-QVS 121

  Fly   157 FDVFTLCMIYMFLPIPSIKGAA--LLASSVSLIYVAFF-----------MHSLTFNAVYTDRDSF 208
            |.:|.:..:|..||:.....||  :::|...|:.:..:           :..|..|||
Mouse   122 FFLFIIFTVYAMLPLGMRDAAAAGVISSLSHLLVLGLYLGWQPESQRALLPQLAANAV------- 179

  Fly   209 GYDVISTDILHNLGFNMMGIFFRIMNDTMVRASFLDR----HQFIMEETWLRHALLQESILLDSI 269
                     |...| |::|.:.:.:.:..:||:|.:.    |.....:|..:|   ||.:|| ||
Mouse   180 ---------LFLCG-NVVGAYHKALMERALRATFREALSSLHSRRRLDTEKKH---QEHLLL-SI 230

  Fly   270 LPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTESFMAIQI--HPDVSILYADVVNYTHLTTTL 332
            ||..:|:.::.:|.:::...:.|      .|..|.:|.::.:  |..||:||||:|.:|.|.:..
Mouse   231 LPAYLAREMKAEIMARLQAGQRS------RPENTNNFHSLYVKRHQGVSVLYADIVGFTRLASEC 289

  Fly   333 TVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQE 397
            :...||.:|::|:|:||..|...:..|||.||||||||:||....||||..||.:|:.|...|::
Mouse   290 SPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRK 354

  Fly   398 VRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSMLN 462
            :|...|:||:||:||||||:|.|:||..|.|:|:|..||.:|||:|:.|.||.||::|.||::|.
Mouse   355 LRVATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLA 419

  Fly   463 PADYTILSGTQKAQS---DPVLQYI--HTYL---------------------LTGQVARES---- 497
            .| |.:    ::|.:   ||.|:.:  .|||                     |.|...|.|
Mouse   420 GA-YAV----ERADTEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAKGLLSSLEGHTMRPSLLMT 479

  Fly   498 -FITSIGG-------------VRSSSVLEVK------SIDRIRSSRPSQSSMTDEFREEFRNMPV 542
             ::.|.|.             |.:|:.|..|      |:||.|:.|.....:.....:.|:.:.
Mouse   480 RYLESWGAAKPFAHLSHLDSPVSTSTPLPEKAFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIE- 543

  Fly   543 GGINLNSPCCRRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIY 607
               .|||        ....|..::..:....|::..:|..|        :.|.|.|:.......:
Mouse   544 ---QLNS--------QKQWKQSKDFNLLTLYFREKEMEKQY--------RLSALPAFKYYAACTF 589

  Fly   608 IQIVTNNFSC--------TACIVVDLVTF--FFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYSCM 662
            : :..:||:.        .|.|:...:||  |||...:|.:.:...|..|..:
Mouse   590 L-VFLSNFTIQMLVTTRPPALIITYSITFLLFFLLLFVCFSEHLTKCVQKGPK------------ 641

  Fly   663 AFHIFEKIQHSVSLR--ITVYLG----ILFSYYAVISLIMLNCDRD-MYELSYIESKIYH--YEM 718
            ..|....:...|:.|  ..|.||    :|....|:.||:.|....| ::..|.:.|..::  :||
Mouse   642 MLHWLPALSVLVATRPGFRVALGTATILLVFTMAIASLLFLPVSSDCLFLASNVSSVTFNASWEM 706

  Fly   719 DRDTCFHPWVFTNMISL-------ILGI--SYTFARIPFGLK-------IVISCCETL---AYL- 763
            ....   |.:...:||:       :||.  ...|..:.|.||       :|.||...|   |:|
Mouse   707 PGSL---PLISIPLISIPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLVASCSLFLHSHAWLS 768

  Fly   764 --LIVFFQFAFIFQHSATTTP--FMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQN 824
              ||     |.::|..:.:.|  ..:.:|...:...:...|:....||:|:..::::.....|:.
Mouse   769 DCLI-----ARLYQSPSDSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQ 828

  Fly   825 KQKAADLTNQSIIILLNNILPSHVVDLYLNSLAKHE-LYYENYRMVSVMFAMLINFP-------- 880
            :::..:.......:||.|:||:||...::....::| ||:::|..|.|:||.:.:|.
Mouse   829 EREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNI 893

  Fly   881 --MNLPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSS 943
              ..|..||:||:||..||.||:. .::..|||||.:|.|||||.||:.....:.:|
Mouse   894 NHEGLECLRLLNEIIADFDELLSK-PKFSGVEKIKTIGSTYMAATGLNATSGQDTQQ-------- 949

  Fly   944 LHVEVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICI 1008
               :.|.:.:|..|                |..||:.|...|...|:        .|.:..::.:
Mouse   950 ---DSERSCSHLGT----------------MVEFAVALGSKLGVINK--------HSFNNFRLRV 987

  Fly  1009 GISSGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTF 1073
            |::.|.::|||:||.:|.||||||.||:||||||||:.|.||||||:|:.||.....|..||...
Mouse   988 GLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGSIK 1052

  Fly  1074 VKGRGDIPTYFVGID 1088
            |||:|::.|||:..|
Mouse  1053 VKGKGELCTYFLNTD 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	57/274 (21%)
		CYCc	293..468	CDD:214485	80/176 (45%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	76/160 (48%)
		CYCc	833..1060	CDD:214485	83/237 (35%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	86/233 (37%)
Adcy4	NP_001348533.1	AC_N	<115..246	CDD:318454	35/152 (23%)
		Guanylate_cyc	264..418	CDD:306677	74/153 (48%)
		DUF1053	479..580	CDD:368844	21/120 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..524		7/21 (33%)
		Guanylate_cyc	866..1065	CDD:306677	87/234 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880