DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and adcy1

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_002933461.1	Gene:	adcy1 / 100492373	XenbaseID:	XB-GENE-950909	Length:	1122	Species:	Xenopus tropicalis

Alignment Length:	1177	Identity:	308/1177 - (26%)
Similarity:	523/1177 - (44%)	Gaps:	232/1177 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TNSRKSPLK--RKRLRPCH------LD-YANERLWEHSYLREKCKELNLEEEYRYYQVRL-MVSN 60
            |:..:.|.:  :.|.:.||      || .|.|..::       |||  ||..::.|.::| ..|.
Frog     4 TDMEEIPFQKVKTRRKKCHCLPAAPLDAIACEDEFD-------CKE--LESLFQNYNLKLEQTST 59

  Fly    61 LTIFYVLFIILAMSFLTIELLYVQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRHRWVMIA 125
            |....||.|:..    |:.||.:....::..:.....|..|:.|:                :.|.
Frog    60 LKALAVLIIMTG----TLALLELMSGPSLTISKGSHPVHCIIFLS----------------LFIV 104

  Fly   126 SSVLSVYLVVLTDIVMISYHF---------------YKNDWPLNTSFDVFTLCMI----YMFLPI 171
            ::|..:.:..|..||.::..|               |..:.|:::...::.|.::    |..||:
Frog   105 TNVKYLQVTQLQQIVKLTLLFGFTFSFLCCPFSLGAYGLEPPVSSEQGLWQLMLVTFVAYALLPV 169

  Fly   172 PSIKGAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDT 236
            .::. |.:....||:.::.     :|..::...:......::...||. :..|:.|:|.||:.:.
Frog   170 RTLL-AIVFGFMVSVSHII-----VTATSISPKKKRLWRTLVVNAILF-VSVNLSGVFVRILTER 227

  Fly   237 MVRASFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPR 301
            ..|.:||.....|.:...|.....::..||.|:||..:|..::|.              |...|.
Frog   228 AQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKED--------------FLKPPE 278

  Fly   302 TTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDC 366
            .....:.||.|.:||||:||:|.:|.|.:..|...|||:|::|:|:||..|:....:|||.||||
Frog   279 RIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDC 343

  Fly   367 YYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDI 431
            ||||:|||.|..|||.|||.:|:.||..|..|.....:|::||:|:|:|.:|.|::|..|.|:|:
Frog   344 YYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDV 408

  Fly   432 WGTDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY-IHTYLLTGQVAR 495
            |..||.:||.:|:.|.||.||::..||..|| .||.:..|....::..:.:: |.|:.:.....|
Frog   409 WSNDVTLANVMEAGGLPGKVHITKNTLECLN-GDYEVEPGYGHERNSFLKKHNIETFFIVPSHRR 472

  Fly   496 ESFITSI-GGVRSSSVLEVKSI-----------DRIRSSRPSQSSMT---DEFR-------EEFR 538
            :.|...| ..::.:..::.|::           ...::..|..:.||   |:.|       |:.|
Frog   473 KIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLR 537

  Fly   539 NMPVGGINL--NSPCCRRT----RLDTHKKTQRE---IGIFCAAFKDSSLEWNYLHQPDFIFKSS 594
            |......|:  |:|..|..    ||...::|..|   :......:|....|..|....|..|.|:
Frog   538 NRSSFSTNVIHNTPGTRVNRYIGRLIEARQTDSEMSDLNFITLKYKHIEREQKYHQLHDEYFTSA 602

  Fly   595 MLLA------WGIGCCLIYIQ--IVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRY 651
            ::|:      :|:...||:.|  ||........|.:|..:.:..:|.:.|..
Frog   603 VVLSLILAALFGLVYLLIFPQSTIVLILLVFCLCFLVACIMYLHVTRVQCFP------------- 654

  Fly   652 EFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNC------DRDMYELSYIE 710
                    .|:          ::.:|..:.:.|:...|:|....::.|      ..:...:..|.
Frog   655 --------GCL----------TIQIRTILCIFIVILIYSVAQGCVVGCMPWIWRSNNSSSIVIIT 701

  Fly   711 SKIYHYEMDR---DTCFHPWVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAF 772
            .|..:..|:.   ||..:.::...:.:|.|.|   |.||....|:|:....|:.|  ||..:.:.
Frog   702 PKGENKTMNERPCDTAHYTFLSCVVGTLSLAI---FLRISSFPKMVLLLFVTILY--IVILEISG 761

  Fly   773 IFQHSATTTPFMKAE---LAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQ---KAADL 831
            ..:.....|.:|:..   ||..|..|.:.|    ..||.:...:::|...|..:.::   :...|
Frog   762 YRKTLGGDTSYMRGYEPILAILLFSCSLAL----HSRQVDLKLRLDYLWAVQAEEERDDMERVKL 822

  Fly   832 TNQSIIILLNNILPSHVVDLYLNSLAKH-ELYYENYRMVSVMFAMLINF----------PMNLPS 885
            .|:.|:.   |:||:||...:|.|..:: :|||::|..|.||||.:.||          .|.:..
Frog   823 DNKRILF---NLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVEC 884

  Fly   886 LRVLNDIITQFDRLL--TAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEV 948
            ||:||:||..||.|:  ..|::   :||||.:|.|||.|.||       :..|......|::
Frog   885 LRLLNEIIADFDELMEKECYKD---IEKIKTIGSTYMGAVGL-------VPTTGTKAKKSIY--- 936

  Fly   949 EHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSG 1013
                :|..|                :..|::::...|...|....:.|..|        :||:.|
Frog   937 ----SHLST----------------LADFSIEMFDVLDEINYQSYNEFVLR--------VGINVG 973

  Fly  1014 EIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKGRG 1078
            .::|||:||.:|.||||||.||:||||:|||:.|.|||||:..:||:..:.:.:.||...|||:|
Frog   974 PVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTEDVHRILKSCNYEFVCRGKVSVKGKG 1038

  Fly  1079 DIPTYFV 1085
            ::.|||:
Frog  1039 EMLTYFL 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	53/271 (20%)
		CYCc	293..468	CDD:214485	79/174 (45%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	75/158 (47%)
		CYCc	833..1060	CDD:214485	82/239 (34%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	82/235 (35%)
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	55/294 (19%)
		CYCc	248..443	CDD:214485	85/209 (41%)
		Guanylate_cyc	284..466	CDD:278633	80/182 (44%)
		CYCc	817..1028	CDD:214485	84/254 (33%)
		Guanylate_cyc	850..1047	CDD:278633	83/237 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910