DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and gucy2g

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_009305067.2	Gene:	gucy2g / 100333350	ZFINID:	ZDB-GENE-130531-70	Length:	1127	Species:	Danio rerio

Alignment Length:	1016	Identity:	202/1016 - (19%)
Similarity:	351/1016 - (34%)	Gaps:	371/1016 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 FMAIQ---IHPDVSILYADVVNYTHLTTTLTVGNLVKVL-------HDLYGRFDIAASNFKVQRI 360
            |:.:|   :...|..|:...|:.|: .|.|...::|.||       :|.|..||.|....|
Zfish   264 FLLVQQFEVSGKVDNLWKTSVSETN-RTMLKAFDMVFVLAEKSYDGYDYYDFFDQAYDKLK---- 323

  Fly   361 KFLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGI-IGE 424
               ||.:|                     |.:|:::||.:....       :|...||..: :.|
Zfish   324 ---GDPFY---------------------SNLSSVKEVSSYAAY-------LHDAVLLYAMGLKE 357

  Fly   425 AKLQFDIWGTDV----EIANHLEST------GEPGYVH---VSGRTLSMLNPADYTILSGTQKAQ 476
            |...    |.|:    ||...|...      |..|.||   ...|.|      ||::.   ...|
Zfish   358 AFKS----GKDIRHGREIVQKLRDRTSIRFYGASGLVHFDEYGERNL------DYSVY---DLQQ 409

  Fly   477 SDPVLQYI-------HTYLLTGQVARESFITSIG------------------------------- 503
            ::.::|::       ||.::...:...:.:...|
Zfish   410 TETLIQFVSVLDFDSHTKMIKPTLRFSNIVWQNGKPPTDNPSCGFDNELCEWLDNEISLLVLLVA 474

  Fly   504 ----GVRSSSVLEVKSIDRIR-SSRPSQS-----SMTD-EFREEFRNMPVGGINLNSPCC----R 553
                ||.:.|::.:.::.::| .||..:|     :.:| ....|.:...:..:|.....|    .
Zfish   475 LPLIGVAAVSLITLLTLQKLRLQSRLDESNWWLINYSDITILREPKGTQILSVNTTPSKCGSGGS 539

  Fly   554 RTRLDTHKKTQRE-----IGIFCAAFKDSSLEWNYL--------HQPDFIFKSSML-------LA 598
            ::.|.::....||     :|:    |:.:.:...||        .:|..|.:.:||       |.
Zfish   540 QSMLSSNSCNTREAIYATVGL----FQGNEVGIKYLKNQIIPDIKKPSIIAEFNMLKEMKHENLV 600

  Fly   599 WGIGCCLIYIQIVTNNFSCTACIVVDLVTFFFLTSLLCLAWYKNVCWWKSGRYEFRIYGKYS-CM 662
            ...|.|:....:         |||:.......|..:|             |.:|..:...:. ..
Zfish   601 QFFGVCIDPPNV---------CIVMQYCKKGSLKDVL-------------GNHEIDLDWMFKLSF 643

  Fly   663 AFHIFEKIQ--HSVSL---------------RITVYL-GI-LFSYYAVISLIMLNCDRDMYELSY 708
            |:.|...::  |..||               |:.:.| |. |:.:.......::..|...||..|
Zfish   644 AYDIVNGMEYIHKSSLKSHGNLRPSTCLVDSRLQIKLSGFGLWEFKCGTKHRLIPLDSPKYEEMY 708

  Fly   709 IESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFA----------------------------- 744
            ..:..:..|:     |:|:..|..     |..|:||
Zfish   709 WTAPEFLREI-----FYPFNGTQK-----GDVYSFAIIIRELIYSTEVGPYHDVHLEPKEIIKQL 763

  Fly   745 RIPFG---LKIVIS---CCETLAYLLIVFFQFAFIFQHSATTTPF--MKAEL--------AHCLR 793
            |.|..   |:..:|   |.|.|..|:...:.     ::.....||  ::.:|        |:.|.
Zfish   764 RTPMSEEPLRPTLSADICDERLIPLIKACWS-----ENPDHRPPFGSIRRQLRDACPESHANILD 823

  Fly   794 VCMMLLTMYA-------KERQSEFNTKMNYKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDL 851
            ..:..|..||       :||.|:        |.|:.....|           ||:::||.::.|
Zfish   824 NMVNKLEKYANHLEEVVEERTSQ--------LTVEKSRADK-----------LLSSMLPRYIAD- 868

  Fly   852 YLNSLAKHELYYENYRMVSVMFAMLINF------PMNLPSLRVLNDIITQFDRLLTAYREYYVVE 910
              ..:|...:...:|.||::.|:.::.|      ...|..:.:|||:.:.||.::..|..|
Zfish   869 --QLMAGKSVEPRSYEMVTIFFSDIVGFTTMCSVSSALEVVTLLNDLYSLFDDIIKLYDVY---- 927

  Fly   911 KIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNNDEVVFIMT 975
            |::.:|..||.|.||..:            |.:||.|.                         ::
Zfish   928 KVETIGDAYMVASGLPIS------------NGTLHAEE-------------------------IS 955

  Fly   976 TFALDLMRTLAACNRAYSSSFFERSLSQGKIC--IGISSGEIMAGVVGASQPHYDIWGNPVNMAS 1038
            |.||..:.::        ..|..|.|...::.  |||:||.::|||||::.|.|.::|:.||.||
Zfish   956 TMALHFLSSI--------KRFKIRHLPNERLALRIGINSGPVVAGVVGSTMPRYCLFGDTVNTAS 1012

  Fly  1039 RMESTGLPGHIQVTEESAKIL---QEFDIKCIYRGMTFVKGRGDIPTYFV-----------GIDE 1089
            ||||..||..|.:::.:|.||   ..|:::  .||...:||:|...|:::           |.|.
Zfish  1013 RMESNSLPLKIHISQSTADILLTIGTFELE--ERGDIEIKGKGTQKTFWLLSKPGFTFPPTGQDS 1075

  Fly  1090 N-----------LKFMSAKLVN------RSLSRRFSVMSSL 1113
            |           :|....|..|      |...:|.|.|:.:
Zfish  1076 NPSPKSGTDSCHIKQEKTKAANDGDFKERRTIQRTSAMTKM 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831
		CYCc	293..468	CDD:214485	42/185 (23%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	39/182 (21%)
		CYCc	833..1060	CDD:214485	63/237 (27%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	64/234 (27%)
gucy2g	XP_009305067.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810