DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gucy1a2

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	XP_009290254.2	Gene:	gucy1a2 / 100330875	ZFINID:	ZDB-GENE-121023-3	Length:	608	Species:	Danio rerio

Alignment Length:	289	Identity:	77/289 - (26%)
Similarity:	134/289 - (46%)	Gaps:	56/289 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 LDRHQFIMEETWLRHALLQES-----ILLDSILPPQIAK------PVQEKIKSKITQSENSPDRF 296
            :|:.:..:|:|   |..|:|.     .||.||.|..:|:      |||.|             :|
Zfish   344 MDKLKATLEKT---HQALEEEKRRTVDLLYSIFPGDVAQRLWQGLPVQAK-------------KF 392

  Fly   297 QMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIK 361
            .                ||::|::|:|.:|.:....|...::.:|::||.|||.......|.:|:
Zfish   393 D----------------DVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGILDVYKIE 441

  Fly   362 FLGDCYYCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAK 426
            .:||.|....||......|||....:.:.|:...:||....|..|.:|||:||||:|||::|...
Zfish   442 TIGDAYCVAGGLHRKIDSHAKPIALMALKMMELSEEVLTPDGKPIKLRIGIHSGSVLAGVVGVMM 506

  Fly   427 LQFDIWGTDVEIANHLESTGEPGYVHVSGRTLSML-NPADYTILSGTQKAQSD------PVLQYI 484
            .::.::|.:|.:|:..||...|..::||..|..:| :...:|.:..:::...|      |.:.|
Zfish   507 PRYCLFGNNVTLASKFESGSHPRCINVSPTTYQLLRDDRSFTFIPRSRQELPDNFPKEIPGICY- 570

  Fly   485 HTYLLTGQVARESFITSIGGVRSSSVLEV 513
              :|..|:....:.:||   .||:.:.:|
Zfish   571 --FLEAGKSQSHASLTS---TRSAPIRKV 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	16/52 (31%)
		CYCc	293..468	CDD:214485	50/175 (29%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	49/159 (31%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gucy1a2	XP_009290254.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900