DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXC and adcy8

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1236	Identity:	340/1236 - (27%)
Similarity:	539/1236 - (43%)	Gaps:	243/1236 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FPRTNSRKSPLKRKRLRPCHLDYANERLWEHSY-------LREKCKELNLEEEYRYYQVRLMVSN 60
            ||..:|......:....|.:.|:...  |.::|       ||...|..:||..|:.|.:.....:
Zfish    93 FPERSSSDLGFLQIDCAPSNSDFFLS--WGYTYRGVIFPTLRYAFKSRDLERLYQRYFLGQRRKS 155

  Fly    61 LTIFYVLFIILAMSFLTIELLY----VQHYNAVFFNFVIRVVSTILVLTVLSINFCEKFVSRH-- 119
            :.:..:|.::..::.|.:.|..    :.....:...|...:...|..|.|:     .|..|.|
Zfish   156 VVVMNILDVVTKLTLLVLHLTLASTPMDPIKGMLLGFFTGIEVVICALVVV-----RKDTSSHGY 215

  Fly   120 -------RWVMIASSVLSVYL--VVLTDIVMISYHFYKNDWPLNTSFDVFTLCMIYMFLPIPSIK 175
                   .||.:|:.:|:..|  .:|.|               ...:.:|||...|..||:| :.
Zfish   216 LQYSGAVTWVAMATQILATGLGYGLLGD---------------GIGYVLFTLFATYSMLPLP-LT 264

  Fly   176 GAALLASSVSLIYVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFNMMGIFFRIMNDTMVRA 240
            .|.:.....|.:::|       ...:...|.....:.:...:|..|..|..|:|...::|...|.
Zfish   265 WAIVAGLLTSALHIA-------LQLLVPPRAQISTNQLLAQVLLFLCINTAGMFISYLSDRAQRQ 322

  Fly   241 SFLDRHQFIMEETWLRHALLQESILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRTTES 305
            :||:..:.|.....|.....::..|:.|:||..:   |.|.| :.:|..|:...:.|
Zfish   323 AFLETRRCIEARLRLETENQRQERLVLSVLPRFV---VLEMI-NDMTNVEDETLQHQ-------- 375

  Fly   306 FMAIQIH--PDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYY 368
            |..|.||  .:||||:|||..:|:|:|||:...||::|::|:.|||..|......|||.||||||
Zfish   376 FHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYY 440

  Fly   369 CVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIWG 433
            ||:||..|.||||.|||.:|:|||..|:.||:....|||||||:||||:|.|::|..|.|||:|.
Zfish   441 CVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWS 505

  Fly   434 TDVEIANHLESTGEPGYVHVSGRTLSMLNPADYTILSGTQKAQSDPVLQY-IHTYLLTGQVARES 497
            .||:|||.|||.|.||.:|:|...|..|| .||.:..|..|.::|.:.:: |.|:|:  :...||
Zfish   506 WDVDIANKLESGGIPGRIHISKAALDCLN-GDYEVEEGHGKDRNDFLRRHNIETFLI--KQPEES 567

  Fly   498 FITSIGGVRSSSVLEVKSIDRIRSSRPSQSSMTD-EFREE--FRNMPVGGINLNSPCCRRT--RL 557
            .:|....:...|..:       ...|.|.:|.|: .:..|  |.|: ||..|..:...|.:  .|
Zfish   568 LLTLPEDIMRDSTNQ-------SDHRTSNTSFTEGTWSPELPFHNI-VGKQNTLAALTRHSINLL 624

  Fly   558 DTH----------------------------KKTQREIGIFCAAFKDSSLEWNYLHQPDFIFKSS 594
            ..|                            |..|..|..|...|:::.||..|....|.:|||:
Zfish   625 PNHLAQALHVRAGSQEINARMQSTIALRSGDKLRQEHISPFSLTFREALLEHKYSQMRDEVFKSN 689

  Fly   595 MLLAWGIGCCLIYIQIVTNNFSC--TACIVVDLVTFFFLTSLLCLAW-------YK-------NV 643
            ::      |..|.:..:|...|.  :|.:|..|:.|..|..|.|...       ||       ..
Zfish   690 LV------CAFIVLFFITGIQSLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKCLPLVLRKA 748

  Fly   644 CWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLGILFSYYAVISLIMLNCDRDMYELSY 708
            |.|.:..|..|                      .:.::|.||.::.|.: :.:|.||.|  :...
Zfish   749 CCWVNETYAAR----------------------NVVIFLSILINFLAAM-INILWCDFD--KSGS 788

  Fly   709 IESKIYHYEMD-RDTCFHP--WVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLI--VFF 768
            ..::.::.... .|.||:|  :|||.:::::  ....|.|:...||:.|.......|.::  .|:
Zfish   789 FRNQTFNASASIPDICFYPEYFVFTGVLAMV--TCAVFLRLNSVLKLAILLIMIAIYAVLTEAFY 851

  Fly   769 QFAFIFQHSAT---TTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQ---NKQK 827
            ...||...:.|   :..|:..:....|.:.|.||.::...:|.|:..::::...|..:   |:.:
Zfish   852 TPLFIRYDTLTLNQSKSFLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMR 916

  Fly   828 AADLTNQSIIILLNNILPSHVVDLYL-NSLAKHELYYENYRMVSVMFAMLINF-------PMN-- 882
            .....|::   :|.|||||||...:| ......|||.::|..|.||||.:..|       .||
Zfish   917 ELREHNEN---MLRNILPSHVARHFLEKDRDNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQ 978

  Fly   883 -LPSLRVLNDIITQFDRLLTAYREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHV 946
             :..||:||:||..||.||...| :..:||||.:|.||||..||                |....
Zfish   979 GVECLRLLNEIIADFDELLGEER-FQDIEKIKTIGSTYMAVSGL----------------SPEKQ 1026

  Fly   947 EVEHARNHRMTDENYDSDMNNDEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGIS 1011
            :.|....|                :..:..||:.|..::...|:        .|.:..::.||::
Zfish  1027 QCEDKWGH----------------LCALADFAIALNESIQEINK--------HSFNNFQLRIGMA 1067

  Fly  1012 SGEIMAGVVGASQPHYDIWGNPVNMASRMESTGLPGHIQVTEESAKILQEFDIKCIYRGMTFVKG 1076
            .|.::|||:||.:|.|||||..||:||||:|||:.|.||:.||:..||.|......|||..:|||
Zfish  1068 HGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNERGFAFEYRGEIYVKG 1132

  Fly  1077 ----RGDIPTYF-VG-IDENLKFMSAKLVNRSLSRRFS-------VMSSLDPDSLRKSSSSDQES 1128
                .|.|.|:| :| :..|...:..    |.|:.::|       ::.||:....::..:.:..|
Zfish  1133 ISEQEGKIRTHFMIGRVQPNPLILQP----RKLTGQYSLAAVVLGLVQSLNRQKQKQILNENNNS 1193

  Fly  1129 G 1129
            |
Zfish  1194 G 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	54/273 (20%)
		CYCc	293..468	CDD:214485	90/176 (51%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	86/160 (54%)
		CYCc	833..1060	CDD:214485	81/237 (34%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	82/238 (34%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	53/270 (20%)
		CYCc	340..538	CDD:214485	98/210 (47%)
		Guanylate_cyc	379..563	CDD:278633	94/186 (51%)
		DUF1053	592..685	CDD:283888	19/93 (20%)
		CYCc	919..1123	CDD:214485	83/247 (34%)
		Guanylate_cyc	948..1147	CDD:278633	82/239 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910