DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXC and gucy1a2

DIOPT Version :9

Sequence 1:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster
Sequence 2:	NP_001120379.1	Gene:	gucy1a2 / 100145454	XenbaseID:	XB-GENE-1011801	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	271	Identity:	74/271 - (27%)
Similarity:	132/271 - (48%)	Gaps:	37/271 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 LDRHQFIMEETWLRHALLQES-----ILLDSILPPQIAKPVQEKIKSKITQSENSPDRFQMGPRT 302
            :|:.:..:|:|   |..|:|.     .||.||.|..:|:.:.|   .|..|:.    :|.
Frog   449 MDKLKATLEKT---HQALEEEKKKTVDLLYSIFPGDVAQQLWE---GKSVQAR----KFD----- 498

  Fly   303 TESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCY 367
                       ||::|::|:|.:|.:....|...::.:|::||.|||.......:.:::.:||.|
Frog   499 -----------DVTMLFSDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAY 552

  Fly   368 YCVAGLTTPDPDHAKCCVSLGISMISNIQEVRAERGLDIDMRIGVHSGSLLAGIIGEAKLQFDIW 432
            ...|||......|||....:.:.|:...:||....|..|.||||:||||:|||::|....::.::
Frog   553 CVAAGLLRQSNSHAKPIALMALKMMELSEEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLF 617

  Fly   433 GTDVEIANHLESTGEPGYVHVSGRTLSML-NPADYTILSGTQKAQSDPVLQYIH--TYLL---TG 491
            |.:|.:|:..||...|..::||..|..:| :.|::..:..:::...|...:.|.  .|.|   :|
Frog   618 GNNVTLASKFESGSHPRRINVSPTTYQLLKDEANFHFVPRSREELPDNFPKEIPGICYFLEADSG 682

  Fly   492 QVARESFITSI 502
            |...:..:||:
Frog   683 QKQPKPSLTSV 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	13/46 (28%)
		CYCc	293..468	CDD:214485	51/175 (29%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	50/159 (31%)
		CYCc	833..1060	CDD:214485
		Nucleotidyl_cyc_III	861..1085	CDD:299850
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<132..248	CDD:377902
		HNOBA	296..486	CDD:369471	12/39 (31%)
		Guanylate_cyc	492..679	CDD:306677	56/206 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910