DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek1 and LINGO1

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_116197.4	Gene:	LINGO1 / 84894	HGNCID:	21205	Length:	620	Species:	Homo sapiens

Alignment Length:	494	Identity:	110/494 - (22%)
Similarity:	165/494 - (33%)	Gaps:	175/494 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLS---------------NE 139
            |...|.|  ....:.|.|..:..:.:||.|...|::||:..|:::||:               ||
Human    42 CPPRCEC--SAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNE 104

  Fly   140 QFIRA-------NLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV------------- 184
            ..:.|       ||.||:.|.||:.::..|....|.||:||.:||:|.|.:|
Human   105 NIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNL 169

  Fly   185 -----------------------------------TVPSLALGHIPSLRELTLASNHIHKIESQA 214
                                               ::|:.||.|:..|..|.|...:|:.|...:
Human   170 KSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYS 234

  Fly   215 FGN------------------TP------SLHKLDLSHC-------------------------- 229
            |..                  ||      :|..|.::||
Human   235 FKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPI 299

  Fly   230 ---------------DIQTISAQ-------AFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGI 272
                           :||.:..|       ||.||..|.:|.::||:|:.|......::..|..:
Human   300 STIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETL 364

  Fly   273 ELHDNPWLCDCRLRDTKLWLMKRNIPYPV---APVCSGGPERIIDRSFAD----LHVDEFACRPE 330
            .|..||..|||||    ||:.:|......   .|.|: .||.:..:.|.|    |..:.|.||..
Human   365 ILDSNPLACDCRL----LWVFRRRWRLNFNRQQPTCA-TPEFVQGKEFKDFPDVLLPNYFTCRRA 424

  Fly   331 ML--PISHYVEAAMGENASITCRARAVPAANINWYWNGRLLA---NNSAFTAYQRIHMLEQVEGG 390
            .:  ..:..|....|......|||...|...|.|....:.|.   :|...|.:.        :|.
Human   425 RIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFP--------DGT 481

  Fly   391 FEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHV 429
            .|.|      .||..|:..:.|:|.|..|.......|||
Human   482 LEVR------YAQVQDNGTYLCIAANAGGNDSMPAHLHV 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	59/299 (20%)
		leucine-rich repeat	123..148	CDD:275380	11/46 (24%)
		LRR_8	148..207	CDD:290566	23/106 (22%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	10/70 (14%)
		LRR_8	195..255	CDD:290566	23/131 (18%)
		leucine-rich repeat	197..220	CDD:275380	8/46 (17%)
		leucine-rich repeat	221..244	CDD:275380	11/70 (16%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		LRRCT	277..327	CDD:214507	18/56 (32%)
		IG_like	338..429	CDD:214653	22/93 (24%)
		Ig	346..426	CDD:143165	19/82 (23%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	9/34 (26%)
		LRR	<66..371	CDD:227223	62/304 (20%)
		LRR 1	72..93		6/20 (30%)
		leucine-rich repeat	73..96	CDD:275380	6/22 (27%)
		LRR 2	96..117		3/20 (15%)
		leucine-rich repeat	97..120	CDD:275380	5/22 (23%)
		LRR_8	120..179	CDD:338972	16/58 (28%)
		LRR 3	120..141		7/20 (35%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR 4	144..165		7/20 (35%)
		leucine-rich repeat	145..192	CDD:275380	6/46 (13%)
		LRR 5	168..189		0/20 (0%)
		LRR 6	192..213		3/20 (15%)
		leucine-rich repeat	193..216	CDD:275380	4/22 (18%)
		LRR 7	216..237		6/20 (30%)
		leucine-rich repeat	217..264	CDD:275380	8/46 (17%)
		LRR 8	264..285		4/20 (20%)
		leucine-rich repeat	265..288	CDD:275380	4/22 (18%)
		LRR 9	288..309		0/20 (0%)
		leucine-rich repeat	289..312	CDD:275380	0/22 (0%)
		LRR 10	312..333		5/20 (25%)
		leucine-rich repeat	313..336	CDD:275380	7/22 (32%)
		LRR 11	336..357		6/20 (30%)
		leucine-rich repeat	337..357	CDD:275380	6/19 (32%)
		PCC	341..>421	CDD:188093	24/84 (29%)
		Ig	439..514	CDD:386229	21/88 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910