DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and lrrc24

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_031759297.1	Gene:	lrrc24 / 779773	XenbaseID:	XB-GENE-923418	Length:	569	Species:	Xenopus tropicalis

Alignment Length:	527	Identity:	128/527 - (24%)
Similarity:	218/527 - (41%)	Gaps:	69/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYL 154
            |...|.|.    ..||||..:.|..:|..|.|:||.:.:..|.:..:  :|...:.|..||.|||
Frog    55 CPAECRCY----SMTVECGSKELRSVPSSIHPSTQTVFLQDNAISQI--QQLDLSPLSGLQYLYL 113

  Fly   155 RNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTP 219
            :|..|..:|...||...:|:||.|:.|.:..:.|.....:..||.|.||.|.|.::.:..|.:..
Frog   114 QNNSISALEPGAFKSQQHLLELALNGNRIHLINSSIFKGLEHLRVLYLAGNQITRLLAYTFSDLQ 178

  Fly   220 SLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCR 284
            .|.:|.|....|:|:..|||.||..|.||.|:.|.:..:....:..|..|..:.|.:|||.|||.
Frog   179 RLQELHLQENSIETLQDQAFSGLSSLALLDLSKNNMRTISRSALRPLISLQVLRLTENPWRCDCA 243

  Fly   285 LRDTKLWL----------MKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHY-V 338
            |...:.|:          :.:.|      :|| .|.|::.:|..|:..:...|.|.|:.:... |
Frog   244 LHWLRAWIKDEGQRLLSSLDKKI------ICS-EPPRLLHQSLVDISGNSLVCIPPMVLVEPMEV 301

  Fly   339 EAAMGENASITCRARAVPAANINWYWNGRLLAN--------NSAFTAYQRIHMLEQVEG-GFEKR 394
            .|.:||...::|||...|...:.|    |.:::        |...|:.::..:.|:..| .|:..
Frog   302 TARLGEELRVSCRATGYPQPLVTW----RKVSHARTGPPKINVKSTSSRKFELSERSVGEQFDAA 362

  Fly   395 S---KLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSM--------RAAGMA-----SLGSGQ 443
            :   .|.|.|...:.:.::.|||.|..|.|:..|.|.|::        .:|.::     .|.|.:
Frog   363 TGSGMLFLNNISMSHAGKYECVASNPGGTAKVLFHLAVNLSNQQSRTYTSADISQEPLYDLESME 427

  Fly   444 IVGLSAALVALIVFALGVI----MCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATG 504
            ...||.|....|...:.::    |.|::.:.|:.:...|......::...::.:..|...|....
Frog   428 FNALSMATQTAIAIGISLLALTAMLLIVMIYRKHHKRKKAKKEENILYVNDYSDGPTTFAQLEEY 492

  Fly   505 NGSIGGVVIANGAVANIIDGGVVQGGTLERKS-----SGRGGVPHGVHDQRSANPVQKPPRLTDL 564
            ....|..:.       :||.......|.:...     ||...:...:.||.:..|..:..|..:.
Frog   493 RDERGHEMF-------VIDRNKAHFPTYKDTECLDSISGLSDLTEQLQDQGTQTPEDEAERQIND 550

  Fly   565 PYSTQGY 571
            .:..||:
Frog   551 IFMNQGF 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	7/18 (39%)
		LRR_RI	<119..277	CDD:238064	49/157 (31%)
		leucine-rich repeat	123..148	CDD:275380	5/24 (21%)
		LRR_8	148..207	CDD:290566	22/58 (38%)
		leucine-rich repeat	149..172	CDD:275380	10/22 (45%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	195..255	CDD:290566	23/59 (39%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		leucine-rich repeat	221..244	CDD:275380	10/22 (45%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		LRRCT	277..327	CDD:214507	15/59 (25%)
		IG_like	338..429	CDD:214653	26/102 (25%)
		Ig	346..426	CDD:143165	20/91 (22%)
lrrc24	XP_031759297.1	LRRNT	54..85	CDD:214470	11/33 (33%)
		leucine-rich repeat	65..83	CDD:275380	7/17 (41%)
		leucine-rich repeat	84..107	CDD:275380	5/24 (21%)
		PPP1R42	87..>236	CDD:411060	45/150 (30%)
		LRR_8	106..166	CDD:404697	22/59 (37%)
		leucine-rich repeat	108..131	CDD:275380	10/22 (45%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRRCT	236..289	CDD:214507	15/59 (25%)
		Ig_3	291..387	CDD:404760	23/99 (23%)
		Ig strand A	291..295	CDD:409353	2/3 (67%)
		Ig strand A'	300..304	CDD:409353	1/3 (33%)
		Ig strand B	307..316	CDD:409353	3/8 (38%)
		Ig strand C	322..328	CDD:409353	2/9 (22%)
		Ig strand C'	345..348	CDD:409353	0/2 (0%)
		Ig strand D	356..359	CDD:409353	1/2 (50%)
		Ig strand E	366..372	CDD:409353	2/5 (40%)
		Ig strand F	379..387	CDD:409353	3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910