DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and Slitrk5

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001365697.1	Gene:	Slitrk5 / 75409	MGIID:	2679448	Length:	982	Species:	Mus musculus

Alignment Length:	574	Identity:	132/574 - (22%)
Similarity:	204/574 - (35%)	Gaps:	180/574 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SGPGGYRPAPSSQNEVYSIADSQPMTEDGYMPPSQHFPPTHSDLDPPAQQQS------------- 88
            |..|.....|:|.|.|  ...|..:.:....||.....|....:.|.::|.|
Mouse   326 STTGYLHTTPASVNSV--ATSSSAVYKPPLKPPKGTRQPNKPRVRPTSRQPSKDLGYSNYGPSIA 388

  Fly    89 ---------TCQTVCACKWKGGK--QTVECIDRHLIQIPEHIDP---NTQVLDMSGNKLQTLSNE 139
                     .|.|.|.|..:...  ..|.|.:|.:..|.| :.|   |.:.:.::.|.:..:...
Mouse   389 YQTKSPVPLECPTACTCNLQISDLGLNVNCQERKIESIAE-LQPKPYNPKKMYLTENYITVVRRT 452

  Fly   140 QFIRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTV-PSLALGHIPSLRELTLA 203
            .|:.|..|:|  |:|.|.:|..|:...|..|.||..|.|:.|.:..: |.|..| :.||:.|.|.
Mouse   453 DFLEATGLDL--LHLGNNRISMIQDRAFGDLGNLRRLYLNGNRIERLSPELFYG-LQSLQYLFLQ 514

  Fly   204 SNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLN--GNKLSEL-LPKTIET 265
            .|.|.:|::..|...|:|..|.|::..:|.:.:..|   .||||||||  ||..:.| :...::.
Mouse   515 YNLIREIQAGTFDPVPNLQLLFLNNNQLQAMPSGVF---SGLTLLRLNLRGNSFTSLPVSGVLDQ 576

  Fly   266 LSRLHGIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHV----DEFA 326
            |:.|..|:||||||.|.|.:...|||:.:..:...|..|....|::     ||:.::    .|..
Mouse   577 LTSLIQIDLHDNPWDCTCDVVGMKLWIEQLKVGVLVDEVICKAPKK-----FAETYMRSIKSELL 636

  Fly   327 CRPE------MLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLE 385
            | |:      ..|....::.....||       |.||..:           ||..|.
Mouse   637 C-PDYSDVVVSTPTPSSIQVPSRTNA-------ATPAVRL-----------NSTGTP-------- 674

  Fly   386 QVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSG---QIVGL 447
                                                               |.||:|   ..|.|
Mouse   675 ---------------------------------------------------AGLGAGTGASSVPL 688

  Fly   448 SAALVALI------VFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNG 506
            |..:::|:      ||....:..|:::.:::...|..:.|:.:| :|.|.|.|:       .|.|
Mouse   689 SVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTSTNNSDV-SSFNMQYSV-------YGGG 745

  Fly   507 SIGGVVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHG-VHDQRSANPVQKPP 559
            ..||                             ||.||. ||.:..|.|..|.|
Mouse   746 GGGG-----------------------------GGHPHAHVHHRGPALPKVKTP 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/21 (29%)
		LRR_RI	<119..277	CDD:238064	52/164 (32%)
		leucine-rich repeat	123..148	CDD:275380	3/24 (13%)
		LRR_8	148..207	CDD:290566	21/59 (36%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	7/23 (30%)
		LRR_8	195..255	CDD:290566	24/61 (39%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	5/22 (23%)
		leucine-rich repeat	245..268	CDD:275380	11/25 (44%)
		LRRCT	277..327	CDD:214507	14/53 (26%)
		IG_like	338..429	CDD:214653	8/90 (9%)
		Ig	346..426	CDD:143165	7/79 (9%)
Slitrk5	NP_001365697.1	leucine-rich repeat	87..104	CDD:275380
		LRR	<97..344	CDD:227223	6/19 (32%)
		leucine-rich repeat	108..131	CDD:275380
		leucine-rich repeat	132..155	CDD:275380
		LRR_8	154..214	CDD:404697
		leucine-rich repeat	156..179	CDD:275380
		leucine-rich repeat	180..203	CDD:275380
		leucine-rich repeat	204..225	CDD:275380
		leucine-rich repeat	227..251	CDD:275380
		PPP1R42	416..>588	CDD:411060	57/178 (32%)
		LRR_8	458..518	CDD:404697	22/62 (35%)
		leucine-rich repeat	460..483	CDD:275380	9/24 (38%)
		leucine-rich repeat	484..507	CDD:275380	7/23 (30%)
		leucine-rich repeat	508..553	CDD:275380	13/47 (28%)
		leucine-rich repeat	555..579	CDD:275380	9/23 (39%)
		TPKR_C2	588..>624	CDD:417692	11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4837
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050