DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek1 and Lingo3

DIOPT Version :9

Sequence 1:NP_001303320.1 Gene:kek1 / 34688 FlyBaseID:FBgn0015399 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_001103079.1 Gene:Lingo3 / 690755 RGDID:1592209 Length:589 Species:Rattus norvegicus


Alignment Length:567 Identity:127/567 - (22%)
Similarity:189/567 - (33%) Gaps:198/567 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 HFPPTHSDLDPPAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTL 136
            |....|..|.|.|...:.|...|.|  ....:||.|..|.|..:||.|...|::|::|.|:::.|
  Rat     6 HMLGLHLLLLPTAPLATGCPARCEC--SASTRTVACGRRRLTAVPEGIPAETRMLELSRNRIRCL 68

  Fly   137 S---------------NEQFIR-------ANLLNLQKLYLR------------------------ 155
            :               |...|.       |||..|:.|.||                        
  Rat    69 NPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTHLDSLTLLDLS 133

  Fly   156 -------------------NCKIGE-----IERETFKGLTNLVELDLSHNLLVTVPSLALGHIPS 196
                               ..::|:     |.|..|.||..|.||.|....|.::...:|||:..
  Rat   134 ENKLVILLDFSFQDLRSLQRLEVGDNDLVFISRRAFAGLLGLAELTLERCNLTSLSPESLGHLRG 198

  Fly   197 LRELTLASNHIHKIESQAFGNTP------------------------SLHKLDLSHCDIQTISA- 236
            |..|.|....|..:|.|.|...|                        :|..|.::|.:|..:.| 
  Rat   199 LGALRLRHLAIAALEDQNFQKLPGLLHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTNITAVPAA 263

  Fly   237 -----------------------------------------------QAFGGLQGLTLLRLNGNK 254
                                                           |||.||:.:.||.|:.|.
  Rat   264 ALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDNL 328

  Fly   255 LSELLPKTIETLSRLHGIELHDNPWLCDCRLRDTKLWLMKR--------NIPYPVAPVCSGG--- 308
            ||.|...|..:::.|..:.:..||..|||||    ||:::|        .:|....|....|   
  Rat   329 LSTLEENTFHSVNTLETLRVDGNPLACDCRL----LWIVQRRKTLNFDGRLPACATPAEVRGDAL 389

  Fly   309 ---PERIIDRSFADLHVDEFACRPEML---PISHYVEAAMGENASITCRARAVPAANINWYWNGR 367
               |:.::        .:.|.||...:   .:.| |.|..|::....|||...||..:.|     
  Rat   390 HNLPDSVL--------FEYFVCRKPKIRERRLQH-VTATEGDDVRFLCRAEGEPAPTVAW----- 440

  Fly   368 LLANNSAFTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAE--ANFTLHVS 430
            :...:.:.||..| .....:.||     .|.:|:.:..||..:.|||.|..|...  |..|:|.:
  Rat   441 VTPQHHSVTAASR-GRARVLPGG-----TLAITDTRPQDSGTYTCVASNAGGNDTYFATLTIHPA 499

  Fly   431 MRAAGMASLGSGQI-----VGLSAALVA----LIVFALGVIM-CLLL 467
            ............|:     :.|:..||:    .|.| |||:: |.||
  Rat   500 ANRTQSDGHNETQVGVRFPLDLTTILVSTAMGCITF-LGVVLFCFLL 545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek1NP_001303320.1 leucine-rich repeat 103..122 CDD:275380 8/18 (44%)
LRR_RI <119..277 CDD:238064 56/299 (19%)
leucine-rich repeat 123..148 CDD:275380 10/46 (22%)
LRR_8 148..207 CDD:290566 21/106 (20%)
leucine-rich repeat 149..172 CDD:275380 10/70 (14%)
leucine-rich repeat 173..196 CDD:275380 8/22 (36%)
LRR_8 195..255 CDD:290566 22/131 (17%)
leucine-rich repeat 197..220 CDD:275380 8/46 (17%)
leucine-rich repeat 221..244 CDD:275380 10/70 (14%)
leucine-rich repeat 245..268 CDD:275380 8/22 (36%)
LRRCT 277..327 CDD:214507 15/63 (24%)
IG_like 338..429 CDD:214653 25/92 (27%)
Ig 346..426 CDD:143165 21/81 (26%)
Lingo3NP_001103079.1 LRRNT 23..55 CDD:214470 11/33 (33%)
leucine-rich repeat 34..53 CDD:275380 8/18 (44%)
LRR <55..353 CDD:227223 56/297 (19%)
leucine-rich repeat 55..78 CDD:275380 5/22 (23%)
leucine-rich repeat 79..102 CDD:275380 5/22 (23%)
leucine-rich repeat 103..150 CDD:275380 4/46 (9%)
leucine-rich repeat 151..174 CDD:275380 6/22 (27%)
leucine-rich repeat 175..198 CDD:275380 8/22 (36%)
leucine-rich repeat 199..222 CDD:275380 7/22 (32%)
leucine-rich repeat 223..246 CDD:275380 0/22 (0%)
LRR_8 246..302 CDD:404697 5/55 (9%)
leucine-rich repeat 247..270 CDD:275380 5/22 (23%)
leucine-rich repeat 271..292 CDD:275380 0/20 (0%)
leucine-rich repeat 295..316 CDD:275380 3/20 (15%)
leucine-rich repeat 319..342 CDD:275380 8/22 (36%)
PCC 331..>405 CDD:188093 19/85 (22%)
Ig 407..489 CDD:416386 24/93 (26%)
Ig strand A' 413..417 CDD:409353 1/4 (25%)
Ig strand B 423..432 CDD:409353 3/8 (38%)
Ig strand C 437..442 CDD:409353 1/9 (11%)
Ig strand C' 445..447 CDD:409353 0/1 (0%)
Ig strand D 456..459 CDD:409353 0/2 (0%)
Ig strand E 462..469 CDD:409353 3/11 (27%)
Ig strand F 475..483 CDD:409353 3/7 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46071
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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