DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek1 and LRTM2

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_016875337.1	Gene:	LRTM2 / 654429	HGNCID:	32443	Length:	427	Species:	Homo sapiens

Alignment Length:	270	Identity:	81/270 - (30%)
Similarity:	113/270 - (41%)	Gaps:	59/270 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 TCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLY 153
            ||...|.|..:  ...|:|....|..:|..:...|:.|.:..|||..|.:..|  |||.:||:|.
Human    95 TCPFSCKCDSR--SLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAF--ANLSSLQRLD 155

  Fly   154 LRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNT 218
            |.|..:..:.|..|..||||.||.|.:|.:.|:....|.|.|.||.|.|:.|.:.::       .
Human   156 LSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQL-------P 213

  Fly   219 PSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDC 283
            |.|                 |.||..|..|.|..|:|..|...|.|.|:.|..:::.||||.|||
Human   214 PGL-----------------FDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDC 261

  Fly   284 RLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACR-PE--------MLPIS--HY 337
            .||:.|.|:  ....|      .||            .:|:.||. |:        |:|:.  :|
Human   262 NLREFKHWM--EWFSY------RGG------------RLDQLACTLPKELRGKDMRMVPMEMFNY 306

  Fly   338 VEAAMGENAS 347
            ......||:|
Human   307 CSQLEDENSS 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	4/18 (22%)
		LRR_RI	<119..277	CDD:238064	49/157 (31%)
		leucine-rich repeat	123..148	CDD:275380	10/24 (42%)
		LRR_8	148..207	CDD:290566	24/58 (41%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	15/59 (25%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..244	CDD:275380	4/22 (18%)
		leucine-rich repeat	245..268	CDD:275380	9/22 (41%)
		LRRCT	277..327	CDD:214507	14/49 (29%)
		IG_like	338..429	CDD:214653	3/10 (30%)
		Ig	346..426	CDD:143165	1/2 (50%)
LRTM2	XP_016875337.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910