DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and RTN4R

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_075380.1	Gene:	RTN4R / 65078	HGNCID:	18601	Length:	473	Species:	Homo sapiens

Alignment Length:	469	Identity:	105/469 - (22%)
Similarity:	157/469 - (33%)	Gaps:	112/469 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 QQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQF-------- 141
            |..:.|...|.| :...|.|..|..:.|..:|..|...:|.:.:.||::..:....|
Human    22 QVAAPCPGACVC-YNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLTI 85

  Fly   142 --IRANLL-------------------------------------NLQKLYLRNCKIGEIERETF 167
              :.:|:|                                     .|..|:|..|.:.|:....|
Human    86 LWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLF 150

  Fly   168 KGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQ 232
            :||..|..|.|..|.|..:|......:.:|..|.|..|.|..:..:||....||.:|.|....:.
Human   151 RGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVA 215

  Fly   233 TISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCRLRDTKLWLMK--- 294
            .:...||..|..|..|.|..|.||.|..:.:..|..|..:.|:||||:||||.|....||.|
Human   216 HVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRG 280

  Fly   295 --RNIPYPVAPVCSGGPERIIDRSFADLHVDEF----------------------------ACRP 329
              ..:|      || .|:|:..|....|..::.                            .|:|
Human   281 SSSEVP------CS-LPQRLAGRDLKRLAANDLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQP 338

  Fly   330 EMLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEKR 394
            :....:..:|.....:|....:.|..|..:.....:|....|:|.|..         :.|..|..
Human   339 DAADKASVLEPGRPASAGNALKGRVPPGDSPPGNGSGPRHINDSPFGT---------LPGSAEPP 394

  Fly   395 SKLVLTNAQE-----TDSSEFYCVAENRAGMAEANFT-LHVSMRAAGMASLGSGQIVGLSAALVA 453
            ...|.....|     |..      ...|.|.:..|.| .|..:..||....|:|...| |.||.:
Human   395 LTAVRPEGSEPPGFPTSG------PRRRPGCSRKNRTRSHCRLGQAGSGGGGTGDSEG-SGALPS 452

  Fly   454 LI--VFALGVIMCL 465
            |.  :..||:.:.|
Human   453 LTCSLTPLGLALVL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	45/204 (22%)
		leucine-rich repeat	123..148	CDD:275380	6/71 (8%)
		LRR_8	148..207	CDD:290566	18/58 (31%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	195..255	CDD:290566	18/59 (31%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	6/22 (27%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	18/82 (22%)
		IG_like	338..429	CDD:214653	17/96 (18%)
		Ig	346..426	CDD:143165	15/84 (18%)
RTN4R	NP_075380.1	LRR 1. /evidence=ECO:0000255	55..79		5/23 (22%)
		leucine-rich repeat	60..82	CDD:275380	4/21 (19%)
		LRR 2. /evidence=ECO:0000255	81..103		2/21 (10%)
		LRR_8	82..142	CDD:338972	6/59 (10%)
		leucine-rich repeat	83..106	CDD:275380	2/22 (9%)
		LRR 3. /evidence=ECO:0000255	104..128		0/23 (0%)
		leucine-rich repeat	107..131	CDD:275380	0/23 (0%)
		LRR 4. /evidence=ECO:0000255	129..152		6/22 (27%)
		leucine-rich repeat	132..155	CDD:275380	8/22 (36%)
		LRR 5. /evidence=ECO:0000255	153..176		7/22 (32%)
		LRR_8	156..214	CDD:338972	17/57 (30%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		LRR 6. /evidence=ECO:0000255	178..200		7/21 (33%)
		leucine-rich repeat	180..203	CDD:275380	7/22 (32%)
		LRR 7. /evidence=ECO:0000255	202..224		6/21 (29%)
		LRR_8	203..261	CDD:338972	18/57 (32%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR 8. /evidence=ECO:0000255	225..248		8/22 (36%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		LRR 9. /evidence=ECO:0000255	250..273		11/22 (50%)
		TPKR_C2	260..>296	CDD:387596	16/42 (38%)
		DUF390	332..>417	CDD:282014	15/99 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..447		23/116 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910