DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek1 and LINGO3

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001094861.1	Gene:	LINGO3 / 645191	HGNCID:	21206	Length:	592	Species:	Homo sapiens

Alignment Length:	558	Identity:	131/558 - (23%)
Similarity:	185/558 - (33%)	Gaps:	201/558 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PPAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLS--------- 137
            |||   ..|...|.|..:  .:.|.|..|.|..:|:.|...|::|::|.|:::.|:
Human    20 PPA---GGCPARCECTVQ--TRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79

  Fly   138 ------NEQFIR-------ANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV----- 184
                  :|..|.       |||..|:.|.||..::..|....|..|.||..||||.|.||
Human    80 LEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDY 144

  Fly   185 TVPSL-------------------------------------------ALGHIPSLRELTLASNH 206
            |...|                                           :|||:.||..|.|....
Human   145 TFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLA 209

  Fly   207 IHKIESQAFGNTPSL-------------------------------------------HK----- 223
            |..:|.|.|...|.|                                           |:
Human   210 IASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTC 274

  Fly   224 LDLSHCDIQT------------------------ISAQAFGGLQGLTLLRLNGNKLSELLPKTIE 264
            |:|||..|.|                        :..|||.||:.:.||.|:.|.||.|...|..
Human   275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFH 339

  Fly   265 TLSRLHGIELHDNPWLCDCRLRDTKLWLMKR--------NIPYPVAPVCSGG------PERIIDR 315
            :::.|..:.:..||..|||||    ||:::|        .:|....|....|      |:.::
Human   340 SVNTLETLRVDGNPLACDCRL----LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVL-- 398

  Fly   316 SFADLHVDEFACRPEMLPISHY--VEAAMGENASITCRARAVPAANINWYW-NGRLLANNSAFTA 377
                  .:.|.||...:.....  |.|..||:....|||...||..:.|.. ..|.:...||..|
Human   399 ------FEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRA 457

  Fly   378 YQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSG 442
              |:     :.||     .|.:.:|:..||..:.|||.|..|......||.|....|...:.|..
Human   458 --RV-----LPGG-----TLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEA 510

  Fly   443 Q---IVGLSAAL---VALIVFALG-------VIMCLLL 467
            .   :..|.|.|   ..|:..|:|       |:.|.:|
Human   511 HNETLAALRAPLDLTTILVSTAMGCITFLGVVLFCFVL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	63/299 (21%)
		leucine-rich repeat	123..148	CDD:275380	10/46 (22%)
		LRR_8	148..207	CDD:290566	25/106 (24%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	13/70 (19%)
		LRR_8	195..255	CDD:290566	26/131 (20%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	13/94 (14%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	15/63 (24%)
		IG_like	338..429	CDD:214653	28/91 (31%)
		Ig	346..426	CDD:143165	22/80 (28%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	10/35 (29%)
		LRR 1	55..76		5/20 (25%)
		LRR_8	57..138	CDD:290566	23/80 (29%)
		LRR_4	59..95	CDD:289563	6/35 (17%)
		leucine-rich repeat	59..79	CDD:275380	4/19 (21%)
		LRR 2	79..100		2/20 (10%)
		leucine-rich repeat	80..103	CDD:275380	5/22 (23%)
		LRR 3	103..124		6/20 (30%)
		leucine-rich repeat	104..127	CDD:275380	7/22 (32%)
		LRR_RI	111..>286	CDD:238064	34/174 (20%)
		LRR_8	127..>172	CDD:290566	11/44 (25%)
		LRR 4	127..148		10/20 (50%)
		leucine-rich repeat	128..151	CDD:275380	10/22 (45%)
		LRR 5	151..172		0/20 (0%)
		leucine-rich repeat	152..199	CDD:275380	3/46 (7%)
		LRR 6	175..196		1/20 (5%)
		LRR_8	198..258	CDD:290566	10/59 (17%)
		leucine-rich repeat	200..223	CDD:275380	7/22 (32%)
		LRR 7	207..228		6/20 (30%)
		leucine-rich repeat	224..247	CDD:275380	1/22 (5%)
		LRR_8	247..303	CDD:290566	7/55 (13%)
		LRR 8	247..268		0/20 (0%)
		leucine-rich repeat	248..271	CDD:275380	1/22 (5%)
		LRR 9	271..292		6/20 (30%)
		leucine-rich repeat	272..293	CDD:275380	6/20 (30%)
		LRR 10	295..316		3/20 (15%)
		leucine-rich repeat	296..319	CDD:275380	5/22 (23%)
		LRR 11	319..340		8/20 (40%)
		leucine-rich repeat	322..343	CDD:275380	8/20 (40%)
		I-set	407..497	CDD:254352	28/101 (28%)
		Ig	422..490	CDD:299845	24/79 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910