DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and Lrrc4

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	153/699 - (21%)
Similarity:	247/699 - (35%)	Gaps:	202/699 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYL 154
            |.:||:|..:..|  |.|..|.|.::|:.|..||:.|::..|.:|.:..:.|  .:|.:|:.|.|
  Rat    45 CPSVCSCSNQFSK--VVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTF--RHLHHLEVLQL 105

  Fly   155 RNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTP 219
            ....|.:||...|.||.:|..|:|..|.|..:||.|..::..||||.|.:|.|..|.|.||...|
  Rat   106 GRNAIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVP 170

  Fly   220 SLHKLDLSHC-DIQTISAQAFGG----------------------LQGLTLLRLNGNKLSELLPK 261
            ||.:|||... .::.||..||.|                      |.||..|.::||...|:.|.
  Rat   171 SLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPG 235

  Fly   262 TIETLSRL------------------------------HG------------------IELHDNP 278
            :...||.|                              |.                  :.||.||
  Rat   236 SFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 300

  Fly   279 WLCDCRLRDTKLWL---MKRNIPYPVAPVCSG---GPERIIDRSFADLHVDEFAC-------RPE 330
            |.|||.:    |||   ::..|  |....|.|   .|..:..|...::....|.|       .|.
  Rat   301 WNCDCDI----LWLAWWLREYI--PTNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAPFIMDAPR 359

  Fly   331 MLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEKRS 395
            .|.||   |..|.|     .:.|..|.:::.|     ||.|.:..:...|...:..:..|....|
  Rat   360 DLNIS---EDRMAE-----LKCRTPPMSSVKW-----LLPNGTVLSHASRHPRISVLNDGTLNFS 411

  Fly   396 KLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVA------- 453
            :::|     .|:..:.|:..|.||.:.|:..|:||.......:......|.:....::
  Rat   412 RVLL-----IDTGVYTCMVTNVAGNSNASAYLNVSSAELNTPNFSFFTTVTVETTEISPEDITRK 471

  Fly   454 ---LIVFALG---------VIMCLLLRVKRQ-PYVDSKTPNHMEVITSVNHQNSITNKTQPATGN 505
               :...:.|         .::....||.:| |...:.|.:.|:  ||::.....|.
  Rat   472 YKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVPVPSTDTTDKMQ--TSLDEVMKTTK-------- 526

  Fly   506 GSIGGVVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQG 570
                 ::|.......::...::......||.          |.|||.....:...:..:
  Rat   527 -----IIIGCFVAVTLLAAAMLIVFYKLRKR----------HQQRSTVTAARTVEIIQV------ 570

  Fly   571 YDNNGSVLSTASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPPISGVGVGGSGEYSRAN 635
             |.:....::|:...:|||.:|.|......|:|...:.:                     |..|:
  Rat   571 -DEDIPAAASAAATAAPSGVSGEGAVVLPTIHDHINYNT---------------------YKPAH 613

  Fly   636 GCDSLYPSGLWEHGA------PVGTTSADDLFMKRYT-DKTPIIDSTQL 677
            |..       |...:      |..||.::...::.:| ||   :..||:
  Rat   614 GAH-------WTENSLGNSLHPTVTTISEPYIIQTHTKDK---VQETQI 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	61/228 (27%)
		leucine-rich repeat	123..148	CDD:275380	6/24 (25%)
		LRR_8	148..207	CDD:290566	23/58 (40%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	28/82 (34%)
		leucine-rich repeat	197..220	CDD:275380	11/22 (50%)
		leucine-rich repeat	221..244	CDD:275380	10/45 (22%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRRCT	277..327	CDD:214507	16/55 (29%)
		IG_like	338..429	CDD:214653	20/90 (22%)
		Ig	346..426	CDD:143165	16/79 (20%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	13/34 (38%)
		LRR_8	74..132	CDD:404697	19/59 (32%)
		LRR 1	75..96		6/22 (27%)
		leucine-rich repeat	76..99	CDD:275380	6/24 (25%)
		PPP1R42	96..300	CDD:411060	54/203 (27%)
		LRR 2	99..120		7/20 (35%)
		leucine-rich repeat	100..123	CDD:275380	9/22 (41%)
		LRR 3	123..144		8/20 (40%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		LRR 4	147..168		11/20 (55%)
		leucine-rich repeat	148..171	CDD:275380	11/22 (50%)
		LRR 5	171..193		9/21 (43%)
		leucine-rich repeat	172..196	CDD:275380	9/23 (39%)
		LRR 6	196..217		0/20 (0%)
		leucine-rich repeat	197..218	CDD:275380	1/20 (5%)
		LRR 7	218..239		7/20 (35%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR 8	242..263		1/20 (5%)
		leucine-rich repeat	243..266	CDD:275380	1/22 (5%)
		LRR 9	266..287		1/20 (5%)
		leucine-rich repeat	267..288	CDD:275380	1/20 (5%)
		LRRCT	299..350	CDD:214507	16/56 (29%)
		IG_like	358..440	CDD:214653	24/99 (24%)
		Ig strand B	369..373	CDD:409353	1/8 (13%)
		Ig strand C	380..384	CDD:409353	1/8 (13%)
		Ig strand E	406..410	CDD:409353	1/3 (33%)
		Ig strand F	420..425	CDD:409353	1/4 (25%)
		Ig strand G	433..436	CDD:409353	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910