Protein Alignment kek1 and LGR6

DIOPT Version :10

• Sequence 1: NP_523559.3
• Gene: kek1 / 34688
• FlyBaseID: FBgn0015399
• Length: 880
• Species: Drosophila melanogaster
• Sequence 2: NP_001017403.1
• Gene: LGR6 / 59352
• HGNCID: 19719
• Length: 967
• Species: Homo sapiens
• Alignment Length: 243
• Identity: 73/243 - (30%)
• Similarity: 104/243 - (42%)
• Gaps: 51/243 - (20%)

  Fly    83 PAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLD-------------------- 127
            |....:.|...|.|:..|...:.:|.:..|..:|..:||.|..||
Human    28 PGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFL 92

  Fly   128 ----MSGNKLQTLSNEQFIRANLLNLQKLYLRNCKIGEIERE----------------------- 165
                :|||.|..:..:.|  :.|.:|:.|.|:|.::|.|..|
Human    93 EELRLSGNHLSHIPGQAF--SGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPE 155

  Fly   166 -TFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHC 229
             :|:||::|..|.|..|.|..:|..||.::|:|:.:|||.|.|..|...||.|..||..|.|.:.
Human   156 RSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN 220

  Fly   230 DIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDN 277
            .||.:...:|.||..|..|.||.|||.| .|..|.||.||..:..|:|
Human   221 RIQHLGTHSFEGLHNLETLDLNYNKLQE-FPVAIRTLGRLQELGFHNN 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_523559.3	leucine-rich repeat	103..122	CDD:275380	4/18 (22%)
		LRR	<122..>277	CDD:443914	62/202 (31%)
		leucine-rich repeat	123..148	CDD:275380	9/48 (19%)
		leucine-rich repeat	149..172	CDD:275380	10/46 (22%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..268	CDD:275380	12/22 (55%)
		LRRCT	277..327	CDD:214507	1/1 (100%)
		IG_like	338..429	CDD:214653
		Ig strand B	346..350	CDD:409353
		Ig strand C	359..363	CDD:409353
		Ig strand E	395..399	CDD:409353
		Ig strand F	409..414	CDD:409353
		Ig strand G	422..425	CDD:409353
LGR6	NP_001017403.1	LRRNT	34..68	CDD:214470	9/33 (27%)
		LRR	<70..>293	CDD:443914	62/201 (31%)
		leucine-rich repeat	70..91	CDD:275380	2/20 (10%)
		LRR 1	91..112		5/22 (23%)
		leucine-rich repeat	92..115	CDD:275380	6/24 (25%)
		LRR 2	115..136		7/20 (35%)
		leucine-rich repeat	116..139	CDD:275380	7/22 (32%)
		LRR 3	139..160		1/20 (5%)
		leucine-rich repeat	140..163	CDD:275380	3/22 (14%)
		LRR 4	163..186		8/22 (36%)
		leucine-rich repeat	164..187	CDD:275380	8/22 (36%)
		LRR 5	187..208		9/20 (45%)
		leucine-rich repeat	188..211	CDD:275380	10/22 (45%)
		LRR 6	211..232		7/20 (35%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		LRR 7	235..256		10/21 (48%)
		leucine-rich repeat	236..258	CDD:275380	12/22 (55%)
		LRR 8	258..279		4/10 (40%)
		leucine-rich repeat	259..282	CDD:275380	3/9 (33%)
		LRR_8	281..364	CDD:404697
		LRR 9	282..303
		leucine-rich repeat	283..304	CDD:275380
		LRR 10	306..328
		LRR 11	329..350
		leucine-rich repeat	330..344	CDD:275378
		LRR	<349..>473	CDD:443914
		LRR 12	353..374
		leucine-rich repeat	354..399	CDD:275380
		LRR 13	375..396
		leucine-rich repeat	376..390	CDD:275378
		LRR 14	399..420
		leucine-rich repeat	400..423	CDD:275380
		LRR 15	423..443
		leucine-rich repeat	424..444	CDD:275380
		7tmA_LGR6	562..834	CDD:320484
		TM helix 1	563..589	CDD:320484
		TM helix 2	597..622	CDD:320484
		TM helix 3	642..672	CDD:320484
		TM helix 4	684..706	CDD:320484
		TM helix 5	728..757	CDD:320484
		TM helix 6	766..796	CDD:320484
		TM helix 7	806..831	CDD:320484