DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and LRRC4C

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001245348.1	Gene:	LRRC4C / 57689	HGNCID:	29317	Length:	640	Species:	Homo sapiens

Alignment Length:	507	Identity:	134/507 - (26%)
Similarity:	200/507 - (39%)	Gaps:	117/507 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 TCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLY 153
            ||.:||:|..:..|  |.|:.::|.::|:.|..||::|::..|::|.:....|  .:|.:|:.|.
Human    46 TCPSVCSCSNQFSK--VICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSF--KHLRHLEILQ 106

  Fly   154 LRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNT 218
            |....|..||...|.||.||..|:|..|.|.|:|:.|..::..|:||.|.:|.|..|.|.||...
Human   107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRI 171

  Fly   219 PSLHKLDLSH-------------------------CD---------------------------- 230
            |||.:|||..                         |:
Human   172 PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRP 236

  Fly   231 ------------------IQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIET-LSRLHGIELHD 276
                              ||.|...||..||.|..:.|..|.|: |||..:.| |..|..|.||.
Human   237 GSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLT-LLPHDLFTPLHHLERIHLHH 300

  Fly   277 NPWLCDCRLRDTKLWL---MKRNIPYPVAPVCS--GGPERIIDRSFADLHVDEFAC-RPEMLPIS 335
            |||.|:|.:    |||   :|...|...| .|:  ..|..:..|...:|..:.|.| .|.::...
Human   301 NPWNCNCDI----LWLSWWIKDMAPSNTA-CCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPP 360

  Fly   336 HYVEAAMGENASITCRARAVPAANINWYW-NGRLLANNSAFTAYQ-RIHMLEQVEGGFEKRSKLV 398
            ..:....|..|.:.||| :....:::|.. ||.::.:.    ||: ||.:|..        ..|.
Human   361 ADLNVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHG----AYKVRIAVLSD--------GTLN 412

  Fly   399 LTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIVFALGVIM 463
            .||....|:..:.|:..|..|...|:.||:|:.......|.       .|...|..:..:.....
Human   413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSY-------FSTVTVETMEPSQDEAR 470

  Fly   464 CLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNK---TQPATG-NGSIGGV 511
            .....|...|.||.:|.|   |.||:..|::.:.:   |.|.|. |..|.|:
Human   471 TTDNNVGPTPVVDWETTN---VTTSLTPQSTRSTEKTFTIPVTDINSGIPGI 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	63/229 (28%)
		leucine-rich repeat	123..148	CDD:275380	6/24 (25%)
		LRR_8	148..207	CDD:290566	23/58 (40%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	27/130 (21%)
		leucine-rich repeat	197..220	CDD:275380	10/22 (45%)
		leucine-rich repeat	221..244	CDD:275380	11/93 (12%)
		leucine-rich repeat	245..268	CDD:275380	9/23 (39%)
		LRRCT	277..327	CDD:214507	16/54 (30%)
		IG_like	338..429	CDD:214653	23/92 (25%)
		Ig	346..426	CDD:143165	20/81 (25%)
LRRC4C	NP_001245348.1	LRRNT	47..80	CDD:214470	12/34 (35%)
		PPP1R42	65..235	CDD:411060	45/171 (26%)
		LRR 1	77..98		6/22 (27%)
		leucine-rich repeat	78..101	CDD:275380	6/24 (25%)
		LRR 2	101..122		7/20 (35%)
		leucine-rich repeat	102..125	CDD:275380	9/22 (41%)
		LRR 3	125..146		9/20 (45%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR 4	149..170		10/20 (50%)
		leucine-rich repeat	150..173	CDD:275380	10/22 (45%)
		LRR 5	173..195		5/21 (24%)
		leucine-rich repeat	174..198	CDD:275380	4/23 (17%)
		LRR 6	198..219		1/20 (5%)
		leucine-rich repeat	199..220	CDD:275380	1/20 (5%)
		LRR_8	220..279	CDD:404697	10/58 (17%)
		LRR 7	220..241		0/20 (0%)
		leucine-rich repeat	221..244	CDD:275380	0/22 (0%)
		LRR 8	244..265		5/20 (25%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		LRR_8	267..>301	CDD:404697	14/34 (41%)
		LRR 9	268..289		7/21 (33%)
		leucine-rich repeat	269..290	CDD:275380	8/21 (38%)
		LRRCT	301..>339	CDD:214507	13/42 (31%)
		IG	360..443	CDD:214652	23/95 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..483		2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910