DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and LRFN1

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_065913.1	Gene:	LRFN1 / 57622	HGNCID:	29290	Length:	771	Species:	Homo sapiens

Alignment Length:	863	Identity:	178/863 - (20%)
Similarity:	274/863 - (31%)	Gaps:	266/863 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LDPP-------------AQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGN 131
            |.||             |.:...|...|.|:......|:.|....|:.:|..||.....|.::.|
Human    11 LSPPPAALPFLLLLWAGASRGQPCPGRCICQNVAPTLTMLCAKTGLLFVPPAIDRRVVELRLTDN 75

  Fly   132 KLQTLSNEQFIRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPS 196
            .:..:....|  ||:.:|..|.|....||::....|..|..|..|.|..|.|..|....|..:.:
Human    76 FIAAVRRRDF--ANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGN 138

  Fly   197 LRELTLASNHIHKIESQAF-GNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSEL-- 258
            ||.|.|.:|.|.::||.|| ....::..||||:.:::.:..:|.|.:..|..|.|:.|.:..:
Human   139 LRHLILGNNQIRRVESAAFDAFLSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAE 203

  Fly   259 -----LPKTIE---TLSRLH-----GIELHD-----------------NPWLCDCRLRDTKLWLM 293
                 |.|.:.   |.:|||     |:.|..                 ||..|:|.|    |||
Human   204 GTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPLTVSFGGNPLHCNCEL----LWL- 263

  Fly   294 KRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAM--GENASITCRARAVP 356
            :|.........|: .||.:.||.|..:..:||.|.|.::.......|.:  |:..|:.|||...|
Human   264 RRLTREDDLETCA-TPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDP 327

  Fly   357 AANINWYW-NGRLLANNSAFTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGM 420
            ...::|.. :||||.|:|.          .:|.|.    ..|.:|.....||..|.|:|.|.||.
Human   328 EPVVHWVAPDGRLLGNSSR----------TRVRGD----GTLDVTITTLRDSGTFTCIASNAAGE 378

  Fly   421 AEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEV 485
            |.|                                    .|.:|::......|...:..|
Human   379 ATA------------------------------------PVEVCVVPLPLMAPPPAAPPP----- 402

  Fly   486 ITSVNHQNSITNKTQPATGNGSIGGVVIANGAVA--NIIDGGVVQGGTLERKSSGRGGVPHGVHD 548
                        .|:|.:.:.:..|...||.:.|  .::...:.....|.|.
Human   403 ------------LTEPGSSDIATPGRPGANDSAAERRLVAAELTSNSVLIRW------------- 442

  Fly   549 QRSANPVQKPP---RLTDLPYSTQGYDNNGSVLSTASCFISPSGSTGNGGNNPDLINDTKRFGSD 610
                 |.|:|.   |:..:.|       |.||..:....:.||.|      ...|:||
Human   443 -----PAQRPVPGIRMYQVQY-------NSSVDDSLVYRMIPSTS------QTFLVND------- 482

  Fly   611 EFADLKIPPISGVGVGGSGEYSRANGCDSLYPSGLWEHGAPVGTTSADDL-FMKRYTDKTPIIDS 674
                                                     :....|.|| .:..|.|....:.:
Human   483 -----------------------------------------LAAGRAYDLCVLAVYDDGATALPA 506

  Fly   675 TQLYDLHERTAATDYFSKTFPRSHLQQGMMTGGGGGTSTASTV---------------------- 717
            |::....:.|.|.|.......|:|...|.|....||...||.:
Human   507 TRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGDSRRVK 571

  Fly   718 ----------TTNLSGGSSSGYPNDYGLPLVPGAEHQHNHQLQMHPLQQLQQQLTSTLN-HQKQE 771
                      ..:.:.|:.:|...   .|.:|..:|       ...|::::.|....:. ..|..
Human   572 GSRSLPRVSHVCSQTNGAGTGAAQ---APALPAQDH-------YEALREVESQAAPAVAVEAKAM 626

  Fly   772 GSSTGSSPHFSSRTLPRLHEGSGGGGSSRS---SPTPAVSGGHANQAANPSTSSSSCSILPNGQP 833
            .:.|.|:.       |.:..|...|||:.|   .|:...||..:..|..|..|.|.....|...|
Human   627 EAETASAE-------PEVVLGRSLGGSATSLCLLPSEETSGEESRAAVGPRRSRSGALEPPTSAP 684

  Fly   834 INAKTIRVWQKGGVPVLP 851
            .....:    .||....|
Human   685 PTLALV----PGGAAARP 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	49/190 (26%)
		leucine-rich repeat	123..148	CDD:275380	5/24 (21%)
		LRR_8	148..207	CDD:290566	19/58 (33%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	195..255	CDD:290566	20/60 (33%)
		leucine-rich repeat	197..220	CDD:275380	10/23 (43%)
		leucine-rich repeat	221..244	CDD:275380	6/22 (27%)
		leucine-rich repeat	245..268	CDD:275380	7/32 (22%)
		LRRCT	277..327	CDD:214507	17/49 (35%)
		IG_like	338..429	CDD:214653	28/93 (30%)
		Ig	346..426	CDD:143165	26/80 (33%)
LRFN1	NP_065913.1	LRR_RI	<65..174	CDD:238064	33/110 (30%)
		LRR_8	65..125	CDD:290566	16/61 (26%)
		LRR 1	66..87		3/22 (14%)
		leucine-rich repeat	67..90	CDD:275380	5/24 (21%)
		LRR 2	90..111		6/20 (30%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR_8	113..174	CDD:290566	21/60 (35%)
		LRR 3	114..135		7/20 (35%)
		leucine-rich repeat	115..138	CDD:275380	7/22 (32%)
		LRR 4	138..159		10/20 (50%)
		leucine-rich repeat	139..163	CDD:275380	10/23 (43%)
		LRR_8	162..222	CDD:290566	13/59 (22%)
		LRR 5	163..184		5/20 (25%)
		leucine-rich repeat	164..187	CDD:275380	6/22 (27%)
		LRR_4	165..203	CDD:289563	10/37 (27%)
		LRR 6	187..208		4/20 (20%)
		leucine-rich repeat	188..211	CDD:275380	5/22 (23%)
		LRR 7	211..232		6/20 (30%)
		leucine-rich repeat	212..230	CDD:275380	4/17 (24%)
		LRRCT	252..>284	CDD:214507	12/37 (32%)
		IG_like	310..385	CDD:214653	28/124 (23%)
		Ig	314..387	CDD:299845	28/122 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		6/41 (15%)
		fn3	426..500	CDD:278470	20/152 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..743		12/49 (24%)
		PDZ-binding	768..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910