DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and lrrc24

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	XP_009297158.1	Gene:	lrrc24 / 565790	ZFINID:	ZDB-GENE-060503-496	Length:	692	Species:	Danio rerio

Alignment Length:	656	Identity:	143/656 - (21%)
Similarity:	235/656 - (35%)	Gaps:	175/656 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PSSQNEVYSIADSQPMTEDGYMPPSQHFPPTHSDLDPP----------AQQQST---CQTVCACK 97
            |||::..|          ..:.|.   |....|:::|.          ||..||   |.:.|.|.
Zfish    78 PSSESLFY----------HSFFPV---FCSVFSEMNPGQMSAVLVLMLAQLCSTSLACPSGCRCY 129

  Fly    98 WKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYLRNCKIGEI 162
                ..||||....:.:||:.|...||.:.:..|.:..:.....  ::|..|..|||:|..|..:
Zfish   130 ----SLTVECGSIGIKEIPQGITQGTQTIFLQDNAIGQIRQRDL--SDLGQLHYLYLQNNSISTL 188

  Fly   163 ERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLS 227
            |...|:.|..|:||.|:.|.:..:.:.....:..||.|.||.|.|:::|...|.....|.:|.|.
Zfish   189 EPGAFRSLGLLLELALNGNRIHLITADVFRGLDHLRILYLAGNQINRLEDYTFRGLQRLQELHLQ 253

  Fly   228 HCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCRLRDTKLWL 292
            ...::.:..||..||..|.||.|:.|.|..|.|.:::.|..|..:.:.||||.|||.|...:.|:
Zfish   254 ENVLEVLGDQALVGLSSLALLDLSRNNLRTLSPASLKPLVSLQVLRVTDNPWRCDCALHWLRGWI 318

  Fly   293 M---KRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPI--SHYVEAAMGENASITCRA 352
            .   :|.:......:....|.|:...|..::..:...|.|.::.:  || :...:||:..::|:|
Zfish   319 NEEGQRLLSSAERRMLCAEPPRLSHLSLVEVPPNSLVCIPPVVQLEPSH-LTVRLGESLRVSCQA 382

  Fly   353 RAVPAANINWYW-------------------------NGRLLANNSAFTAYQRIHMLEQVEGGFE 392
            ...|...:.|..                         .|||:............|  ..:.||.:
Zfish   383 SGYPQPQVTWRKASHGKAQLSPRGLVQEVGMDGDTRNGGRLVTARPGGKGGPSSH--GPIRGGAD 445

  Fly   393 K------------RSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMAS------- 438
            .            ...|.|:|.....:..:.|.|.|..|:|...|.|.|:|.::...|
Zfish   446 DGADRENFDPDTGSGMLFLSNVTVAHAGRYECEAWNPGGVARVTFHLSVNMSSSSSRSEIWPRLH 510

  Fly   439 ---------------------------LGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQ---- 472
                                       ||:.....::..:..|.:.|| :::|::....||
Zfish   511 SSSYYHPSSVDVSQEPLYELESMDFNALGTATQTAIAVGISLLALTAL-LLLCMIYSRHRQRQKE 574

  Fly   473 --PYVDSKTPNHMEVITSVN--------------------HQNSITNKTQPATGNGSIGGVVIAN 515
              .|..||.    |.|..||                    |:..:.|:.:|          |:|.
Zfish   575 EGGYGASKE----ESILYVNDYSDGPTTFAQLEEYRDERGHEMYVLNRAKP----------VLAP 625

  Fly   516 GAVANIIDGGVVQGGTLERKSS--------GRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGYD 572
            ..:.       :|.|:...|:|        ||.|   |:..:|:.....:.|     |...:|..
Zfish   626 QPMC-------IQQGSATLKASECQGVLTPGRAG---GIGPRRAPAEGGEAP-----PLDPEGLF 675

  Fly   573 NNGSVL 578
            .|.|:|
Zfish   676 MNQSLL 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	7/18 (39%)
		LRR_RI	<119..277	CDD:238064	45/157 (29%)
		leucine-rich repeat	123..148	CDD:275380	4/24 (17%)
		LRR_8	148..207	CDD:290566	20/58 (34%)
		leucine-rich repeat	149..172	CDD:275380	9/22 (41%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	195..255	CDD:290566	21/59 (36%)
		leucine-rich repeat	197..220	CDD:275380	9/22 (41%)
		leucine-rich repeat	221..244	CDD:275380	7/22 (32%)
		leucine-rich repeat	245..268	CDD:275380	9/22 (41%)
		LRRCT	277..327	CDD:214507	12/52 (23%)
		IG_like	338..429	CDD:214653	22/127 (17%)
		Ig	346..426	CDD:143165	18/116 (16%)
lrrc24	XP_009297158.1	leucine-rich repeat	151..174	CDD:275378	4/24 (17%)
		LRR_8	174..257	CDD:290566	26/82 (32%)
		LRR_4	174..238	CDD:289563	21/63 (33%)
		leucine-rich repeat	175..222	CDD:275378	14/46 (30%)
		leucine-rich repeat	199..218	CDD:275380	5/18 (28%)
		LRR_8	222..304	CDD:290566	27/81 (33%)
		LRR_4	222..258	CDD:289563	12/35 (34%)
		leucine-rich repeat	223..246	CDD:275378	9/22 (41%)
		leucine-rich repeat	247..294	CDD:275378	16/46 (35%)
		leucine-rich repeat	295..307	CDD:275378	5/11 (45%)
		LRRCT	303..356	CDD:214507	12/52 (23%)
		IG_like	365..494	CDD:214653	24/131 (18%)
		Ig	376..491	CDD:143165	18/116 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910