DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek1 and lrit1a

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	551	Identity:	129/551 - (23%)
Similarity:	212/551 - (38%)	Gaps:	136/551 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QSTCQTVCACKW----KGGK-QTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANL 146
            :|||.|.|:|.:    .|.: ::|.|.|..:..:|.....:|..|.:....::.:.:|.|  :.|
Zfish    20 RSTCPTQCSCFYHNLSDGSRARSVICNDPEISLVPASFPGDTSKLRIEKTAIKRIPSEAF--SYL 82

  Fly   147 LNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIE 211
            .||:.|::....:..:..::|:||.:|.||.|..|.|.:.|..:|..:||||.|.:.:|.:..:.
Zfish    83 SNLEFLWMSFNVLSSLNSDSFRGLYSLEELRLDGNSLSSFPWESLMDMPSLRLLDIHNNQLSSLP 147

  Fly   212 SQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHD 276
            |:|.....::..||||..::.|:.|:...  ..||:....|.:.|:|:            :.|||
Zfish   148 SEAALYMKNITYLDLSSNNLLTVPAEVLN--TWLTIKPTLGAESSKLI------------LGLHD 198

  Fly   277 NPWLCDCRLRDTKLWLMKRNIPYPVAPVCS----------GGPERIIDRSFADLHVDEFACR-PE 330
            |||||||||.|.        :.:..:|..|          ..||.:....|:|..:..  |: |.
Zfish   199 NPWLCDCRLYDL--------VQFQKSPSLSVAFIDTRLRCADPESLSGVLFSDAELRR--CQGPR 253

  Fly   331 MLPISHYVEAAMGENASITCRARAVPAANINWY------WNGRLLANNSAFTAYQRIHMLEQVEG 389
            :......|.:|:|.|..:.|....||...:.|.      .||.:|..||.             ||
Zfish   254 VHTAVARVRSAVGNNVLLRCGTVGVPIPELAWRRADGKPLNGTVLLENSK-------------EG 305

  Fly   390 GFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVAL 454
              ...|.|.:......|:.::.|.|.|.||.||                           |:::|
Zfish   306 --IVWSILSVPAVSYRDTGKYICKATNYAGSAE---------------------------AVISL 341

  Fly   455 IVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNG-SIGGVVIANGAV 518
            |:.....:....|..|  |.:.||.||.|  :.:...:..|.....|...|| .:.|.|
Zfish   342 IINDAPKMENPTLDPK--PKLKSKKPNTM--VKAAYQEKHIATYVSPTPKNGLPLSGTV------ 396

  Fly   519 ANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGY-DNNGSVLSTAS 582
                              |..|..| |:....:||     .|:.....|..|: :.|.|.|
Zfish   397 ------------------SYTGPYP-GMESDNAAN-----SRMNTQTASPDGFLETNLSNL---- 433

  Fly   583 CFISPSGSTGNGGNNPD-LINDTKRFGSDEF 612
                 :.:|.:...:|| ::...|..|..::
Zfish   434 -----AANTSSLQQDPDRVVRSVKVIGDTDY 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	4/18 (22%)
		LRR_RI	<119..277	CDD:238064	40/157 (25%)
		leucine-rich repeat	123..148	CDD:275380	5/24 (21%)
		LRR_8	148..207	CDD:290566	20/58 (34%)
		leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	17/59 (29%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		leucine-rich repeat	221..244	CDD:275380	6/22 (27%)
		leucine-rich repeat	245..268	CDD:275380	5/22 (23%)
		LRRCT	277..327	CDD:214507	16/59 (27%)
		IG_like	338..429	CDD:214653	25/96 (26%)
		Ig	346..426	CDD:143165	21/85 (25%)
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378	5/24 (21%)
		LRR_8	63..119	CDD:290566	15/57 (26%)
		LRR_RI	<77..175	CDD:238064	31/99 (31%)
		leucine-rich repeat	85..108	CDD:275378	5/22 (23%)
		LRR_8	108..167	CDD:290566	20/58 (34%)
		leucine-rich repeat	109..132	CDD:275378	8/22 (36%)
		leucine-rich repeat	133..156	CDD:275378	6/22 (27%)
		leucine-rich repeat	157..170	CDD:275378	4/12 (33%)
		LRRCT	199..243	CDD:214507	15/51 (29%)
		I-set	252..343	CDD:254352	28/132 (21%)
		Ig	259..333	CDD:299845	21/88 (24%)
		fn3	448..515	CDD:278470	2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6040
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910