DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek1 and lrit2

DIOPT Version :9

Sequence 1:NP_001303320.1 Gene:kek1 / 34688 FlyBaseID:FBgn0015399 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_001018372.2 Gene:lrit2 / 553557 ZFINID:ZDB-GENE-050522-160 Length:561 Species:Danio rerio


Alignment Length:383 Identity:102/383 - (26%)
Similarity:157/383 - (40%) Gaps:64/383 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 STCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKL 152
            |.|...|:|......:::.|::..|..||:.:..:...:.:..::|..|....|  :::..|:.|
Zfish    21 SECFPGCSCGTDRHGRSLTCMETALTGIPDGLPEDLTKIRIEKSQLSELPEAVF--SHVKALKHL 83

  Fly   153 YLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGN 217
            :|....|..|..::.:||.||.||.|..|.|.:||                        ..||..
Zfish    84 WLNFNDIAIINIKSLEGLANLTELRLQGNKLRSVP------------------------WTAFEE 124

  Fly   218 TPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHG----------- 271
            ||:|..|||.|..|..:...|...|.|||.|.|:.|:||.:...........|.           
Zfish   125 TPNLKILDLKHNRIDALPEHALKFLPGLTYLDLSSNQLSVISKDVFLNWPLYHSENKHEKPSASN 189

  Fly   272 --IELHDNPWLCDCRLRDTKLWLMKRNIPYPVAP---VCSGGPERIIDRSFADLHVDEFAC-RPE 330
              :.||||||||||||.....::.....|:.:..   .|| .||....|.|.:  ||...| :|.
Zfish   190 VVLALHDNPWLCDCRLGGFIEFIKSLTPPFILMNSYLTCS-SPELKAGRFFHE--VDLKTCVKPV 251

  Fly   331 MLPISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRI--HMLEQVEGGFEK 393
            :......:.|.:|.|.::||.|.|.|.|.|.|.:..::|      ..::.|  |:.|....    
Zfish   252 VSAPVITITAPLGGNVTLTCSASARPEAVIRWIYALKML------RGFRDILSHVDEDTIS---- 306

  Fly   394 RSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAAL 451
             |:||:.:....|...:.|:|.|..|.:....::.|. ...|.:|..||.    |||:
Zfish   307 -SQLVIPSLHSADRGLYTCIANNFLGNSSVIISVDVK-SPEGSSSHPSGP----SAAI 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek1NP_001303320.1 leucine-rich repeat 103..122 CDD:275380 4/18 (22%)
LRR_RI <119..277 CDD:238064 42/170 (25%)
leucine-rich repeat 123..148 CDD:275380 3/24 (13%)
LRR_8 148..207 CDD:290566 16/58 (28%)
leucine-rich repeat 149..172 CDD:275380 7/22 (32%)
leucine-rich repeat 173..196 CDD:275380 8/22 (36%)
LRR_8 195..255 CDD:290566 18/59 (31%)
leucine-rich repeat 197..220 CDD:275380 3/22 (14%)
leucine-rich repeat 221..244 CDD:275380 8/22 (36%)
leucine-rich repeat 245..268 CDD:275380 7/22 (32%)
LRRCT 277..327 CDD:214507 18/52 (35%)
IG_like 338..429 CDD:214653 23/92 (25%)
Ig 346..426 CDD:143165 20/81 (25%)
lrit2NP_001018372.2 LRR 1 55..76 3/22 (14%)
LRR_8 56..114 CDD:290566 16/59 (27%)
leucine-rich repeat 56..79 CDD:275378 3/24 (13%)
LRR_4 78..118 CDD:289563 14/39 (36%)
LRR 2 79..102 6/22 (27%)
leucine-rich repeat 80..103 CDD:275378 7/22 (32%)
LRR_8 103..162 CDD:290566 27/82 (33%)
LRR_4 103..143 CDD:289563 19/63 (30%)
LRR 3 103..124 11/44 (25%)
leucine-rich repeat 104..127 CDD:275378 11/46 (24%)
LRR_4 126..166 CDD:289563 17/39 (44%)
LRR 4 127..150 7/22 (32%)
leucine-rich repeat 128..151 CDD:275378 8/22 (36%)
LRR 5 151..172 8/20 (40%)
leucine-rich repeat 152..165 CDD:275378 7/12 (58%)
leucine-rich repeat 189..201 CDD:275378 6/11 (55%)
TPKR_C2 197..240 CDD:301599 15/43 (35%)
IG_like 258..341 CDD:214653 23/93 (25%)
IGc2 264..328 CDD:197706 20/74 (27%)
fn3 366..438 CDD:278470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..561
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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