DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and islr2

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	788	Identity:	158/788 - (20%)
Similarity:	266/788 - (33%)	Gaps:	248/788 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYL 154
            |...|||..|...|.|:|..:.|:::|..:..|...|.:|.||::.|.::.|:  |:..:..|:|
Zfish    22 CPKQCACSDKYNHQFVDCAYKDLVEVPVGLPSNASTLSLSANKIKVLKSKTFV--NVTQVTSLWL 84

  Fly   155 RNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTP 219
            .:.:|..:||:|...|..|..||:|:|.:|..|...|.::.:|:.|.:.:|.:..|...||.|
Zfish    85 AHNEIITVERDTLAPLIQLKNLDISNNKIVHFPWEDLANLGALQLLKMNNNEMVSIPKNAFSN-- 147

  Fly   220 SLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCR 284
                                  |:.|..:|:|.||.:.::..|.::|:.:..:::..||::|.|.
Zfish   148 ----------------------LKDLRSIRINNNKFTTIVQGTFDSLAAMSHLQIFHNPFICSCN 190

  Fly   285 LRDTKLWLMKRNIPYPVA-PVCSGGPERIIDRSFADLHVDEFACRPEMLPISHY-----VEAAMG 343
            |...:.|::|.:|..|.. .:....|..:.......:  .:..|:...:.|::.     .|...|
Zfish   191 LEWLRDWILKSSISIPEQNNIACDAPSHLKGSQVTSM--PKLNCKAPSVSITYQPNIEKTELYEG 253

  Fly   344 ENASITCRARAVPAANINW--YWNGRLLA------------------NNSAFTAYQRIHMLEQVE 388
            ....:.|..:..|...:.|  :...:|:.                  .|:.|..:|
Zfish   254 YMVMLYCETKGTPKPEVTWEIFAGNQLITFPLPAIVEKSDIPINGPPTNTRFLVFQ--------- 309

  Fly   389 GGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVS------------MRAAGMA---S 438
                 ...|::....:.:...:.|.|.|..|.||::..|.|:            .::.|:.   .
Zfish   310 -----NGTLIVPRMSKKEEGNYTCSAVNDIGKAESSVRLVVAGTKKHATNSMLDTKSPGLLPEDK 369

  Fly   439 LGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKT---PNHMEVITSVNHQNSITNKTQ 500
            |||   .|...:::::                 :|..:.||   |....|||....|......|.
Zfish   370 LGS---KGSKNSVISM-----------------RPKFEEKTKSLPTGTSVITVDKEQVDEGADTL 414

  Fly   501 PATGNGSI--GGVVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRS---ANPVQKPPR 560
            |..|...|  |...|:|.|....:|       .|::.:...|.:...|.:..:   .||:|....
Zfish   415 PFVGKCGINDGTQYISNHAFNLSLD-------ELKQYTFDFGVIALEVSETEAKVQLNPMQMANA 472

  Fly   561 LTDLPYS----TQGYDNNGSVLSTASCFISPSG------STGNG--------------------- 594
            .:::..|    .|..:.....|...|...||..      |||||
Zfish   473 KSNIHLSQQQDLQTVNKEPFSLFQTSAKKSPLDLLYLCVSTGNGHSVVQWSKIEEGVNAYRFQHL 537

  Fly   595 --GNNPDL-------------INDTKRFGSDEFADLKIP------------------PISGVGVG 626
              |.|..|             :..|::         |||                  |:.|
Zfish   538 KPGTNYTLCLTYGGQDCQVQVVFTTRK---------KIPSLLIIVVVSIFLLALATVPLLG---- 589

  Fly   627 GSGEYSRANGCDSLYPSGLWEHGAPVGTTSADDLFMKRYTDKT-PIIDSTQLYDLHERTAATDY- 689
                   |..|..||                      :|..|| .:|..||..|..|:..|||:
Zfish   590 -------ATCCHLLY----------------------KYQGKTYKLIMKTQNPDQMEKNIATDFD 625

  Fly   690 -------FSKTFPRSHLQQGM-----MTGGGGGTSTASTVTTNLSGGSSSGYPNDY--------G 734
                   ..|.|..|.:.:|.     ..|.|.|.....:|.|.....|.|....::        .
Zfish   626 PRASFVGSEKNFNPSEMGEGEGEADGEEGDGEGEDIEGSVVTESIPESQSKTQEEFEVGSEYSDR 690

  Fly   735 LPLVPGAE 742
            |||  |||
Zfish   691 LPL--GAE 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	38/157 (24%)
		leucine-rich repeat	123..148	CDD:275380	7/24 (29%)
		LRR_8	148..207	CDD:290566	18/58 (31%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	12/59 (20%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	1/22 (5%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRRCT	277..327	CDD:214507	10/50 (20%)
		IG_like	338..429	CDD:214653	17/110 (15%)
		Ig	346..426	CDD:143165	14/99 (14%)
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	5/17 (29%)
		LRR_RI	<47..>184	CDD:238064	39/162 (24%)
		LRR_8	53..113	CDD:290566	20/61 (33%)
		leucine-rich repeat	57..78	CDD:275380	7/22 (32%)
		leucine-rich repeat	79..102	CDD:275380	7/22 (32%)
		LRR_8	102..161	CDD:290566	20/82 (24%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275380	8/46 (17%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		LRRCT	183..>221	CDD:214507	10/37 (27%)
		IG_like	252..345	CDD:214653	16/106 (15%)
		Ig	256..345	CDD:299845	15/102 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910