DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and LRRC24

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001019849.2	Gene:	LRRC24 / 441381	HGNCID:	28947	Length:	513	Species:	Homo sapiens

Alignment Length:	506	Identity:	128/506 - (25%)
Similarity:	194/506 - (38%)	Gaps:	98/506 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYL 154
            |...|.|.    ..||||....|..:|..|.|.||.|.:..|.:..|  |....|.|..|::|||
Human    23 CPAACRCY----SATVECGALRLRVVPLGIPPGTQTLFLQDNNIARL--EPGALAPLAALRRLYL 81

  Fly   155 RNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTP 219
            .|..:..:|...|:....|:||.|:.|.|..:.|.|...:..||.|.||.|.:.::....|.:.|
Human    82 HNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLP 146

  Fly   220 SLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCR 284
            .|.:|.|....|:.:..||..||..|.||.|:.|:|..:..:.::.|:.|..:.|.:|||.|||.
Human   147 RLQELHLQENSIELLEDQALAGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCA 211

  Fly   285 LRDTKLWLM---KRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHY----VEAAM 342
            |.....|:.   :|.:......:....|.|:..:|..|:......|.|   |..|.    :.|.:
Human   212 LHWLGAWIKEGGQRLLTSRDRKIMCAEPPRLALQSLLDVSHSSLICIP---PSVHVQPLELTANL 273

  Fly   343 GENASITCRARAVPAANINWY-----WNGRLLANNSAFTAYQRIHMLEQVEGGF----------E 392
            ||:..:.|:|...|...:.|.     ..||..|.             .|:|||.          .
Human   274 GEDLRVACQASGYPQPLVTWRKVPQPREGRPRAQ-------------AQLEGGLLGLGGHSASDT 325

  Fly   393 KRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHV----------------SMRAAG------ 435
            ....|.|:|.....:.::.|.|.|..|.|...|.|.|                :.|.||
Human   326 GSGMLFLSNITLAHAGKYECEASNAGGAARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPE 390

  Fly   436 ---MA--SLGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQ---------------PYVDSK-T 479
               ||  :||......::||:..|.:.||.::..:..|.:|:               .|:|.. |
Human   391 AGSMAFRALGVATQTAIAAAIALLALTALLLVAMICRRRRRRKKARGPPGEGALFVNDYLDGPCT 455

  Fly   480 PNHMEVITSV-NHQNSITNKTQPATGNGSIGGVVIANGAVANIIDGGVVQG 529
            ...:|.:... .|:..:.|:::|          :.|.|......|.|..||
Human   456 FAQLEELRDERGHEMFVINRSKP----------LFAEGPAEAPADCGPEQG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	7/18 (39%)
		LRR_RI	<119..277	CDD:238064	50/157 (32%)
		leucine-rich repeat	123..148	CDD:275380	8/24 (33%)
		LRR_8	148..207	CDD:290566	21/58 (36%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	8/22 (36%)
		LRR_8	195..255	CDD:290566	21/59 (36%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRRCT	277..327	CDD:214507	13/52 (25%)
		IG_like	338..429	CDD:214653	24/105 (23%)
		Ig	346..426	CDD:143165	19/94 (20%)
LRRC24	NP_001019849.2	LRR_RI	49..>158	CDD:238064	35/110 (32%)
		LRR_8	<50..86	CDD:290566	14/37 (38%)
		LRR 1	51..72		6/22 (27%)
		leucine-rich repeat	53..75	CDD:275380	7/23 (30%)
		LRR 2	75..96		7/20 (35%)
		LRR_8	76..134	CDD:290566	21/57 (37%)
		leucine-rich repeat	76..99	CDD:275380	7/22 (32%)
		LRR 3	99..120		8/20 (40%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	123..205	CDD:290566	25/81 (31%)
		LRR 4	123..144		7/20 (35%)
		leucine-rich repeat	124..147	CDD:275380	7/22 (32%)
		LRR 5	147..168		6/20 (30%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		LRR 6	171..192		6/20 (30%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRRCT	204..257	CDD:214507	13/52 (25%)
		Ig	259..364	CDD:299845	28/120 (23%)
		IG_like	266..362	CDD:214653	24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..391		3/25 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870