DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and Lrt

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	126/574 - (21%)
Similarity:	199/574 - (34%)	Gaps:	187/574 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QVLDMSGNKL-----------QTLSNEQF-IRANLLNLQKLYLRNCKIGEIERETFKGLTNLVEL 176
            :||.:.||:|           |.||..|. ::||.||           |.:..:|..|:.||..|
  Fly   298 EVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNLN-----------GPLSEQTLPGMRNLESL 351

  Fly   177 DLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGG 241
            :|:.||:.::.:.||.:...|..|:|..|.|..::..||....:|..||||:..|..||:.:...
  Fly   352 NLNRNLIKSIQNKALANFSRLVSLSLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAISSASLQH 416

  Fly   242 LQGLTL------------------------LRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCD 282
            |..||:                        |||.||.:|.:....::....|..:::.:||..||
  Fly   417 LSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGNDISIVARNAMDGARELESLQMQENPLSCD 481

  Fly   283 CRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEMLPISHYVEAAMGENAS 347
            |.:|....||.:..:...::..|. .|.|:.......:.|:..:|.         ::....:||:
  Fly   482 CSIRPFAEWLQESQLHSSLSASCV-TPPRLEGAPLLQVPVETLSCD---------MDNVEKDNAN 536

  Fly   348 ITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEKRSKLVLTNAQET----DSS 408
            |                                   ::.:|         .|....:|    |.|
  Fly   537 I-----------------------------------MQHLE---------TLAKPNQTSPIKDLS 557

  Fly   409 EFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQP 473
            |...:.|           ||.|              ......|..|:..:....||..:.|.::.
  Fly   558 EEIILHE-----------LHFS--------------TDYGLILTWLLNLSKKDYMCDAIFVYKEE 597

  Fly   474 YVD----SKTPNHMEVITSVNHQNSITNKTQPATGNGSIGG------VVIANGAVANIIDGGVVQ 528
            :::    ..:|.|.| ...||.||:: :...|.:.:..||.      |:|......:.::.|...
  Fly   598 HINEILIDNSPIHCE-SKVVNGQNTV-SVIVPDSSSLEIGESYRFCLVMIQEQKPDSELNIGCSN 660

  Fly   529 GGTLERKSSGRGGV----------------PHGVHD--------QRSANP-VQKPPRLTD---LP 565
            ...|||.|.|...|                |..|||        ||..|. |...|:.|.   |.
  Fly   661 ITRLERSSPGAVPVSRQYQRRPYYNANELKPEVVHDAGEDYQVNQRRFNSVVGSQPQQTQQSTLL 725

  Fly   566 YSTQGYDN-NGS--------VLST--------ASCFISPSGSTGNGGNNPDLIN 602
            :|....|: |.|        ||.|        |:......||:|.||.|.|.|:
  Fly   726 HSYTVIDSLNKSFLPGLGLGVLVTSVLVLIWGATRIRQTGGSSGGGGRNGDSID 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380
		LRR_RI	<119..277	CDD:238064	49/188 (26%)
		leucine-rich repeat	123..148	CDD:275380	11/35 (31%)
		LRR_8	148..207	CDD:290566	16/58 (28%)
		leucine-rich repeat	149..172	CDD:275380	3/22 (14%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	195..255	CDD:290566	23/83 (28%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	8/46 (17%)
		LRRCT	277..327	CDD:214507	12/49 (24%)
		IG_like	338..429	CDD:214653	11/94 (12%)
		Ig	346..426	CDD:143165	9/83 (11%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	11/35 (31%)
		leucine-rich repeat	179..199	CDD:275378
		leucine-rich repeat	200..223	CDD:275380
		leucine-rich repeat	225..248	CDD:275380
		LRR_8	249..307	CDD:290566	4/8 (50%)
		leucine-rich repeat	249..272	CDD:275380
		LRR_RI	<270..479	CDD:238064	51/191 (27%)
		leucine-rich repeat	273..296	CDD:275380
		leucine-rich repeat	297..322	CDD:275380	6/23 (26%)
		LRR_8	322..382	CDD:290566	21/70 (30%)
		leucine-rich repeat	323..347	CDD:275380	8/34 (24%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		LRR_8	370..428	CDD:290566	18/57 (32%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		leucine-rich repeat	396..419	CDD:275380	9/22 (41%)
		LRR_8	418..478	CDD:290566	10/59 (17%)
		leucine-rich repeat	420..443	CDD:275380	2/22 (9%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRRCT	476..526	CDD:214507	12/50 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010