DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and rk

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_476702.1	Gene:	rk / 34819	FlyBaseID:	FBgn0003255	Length:	1360	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	104/466 - (22%)
Similarity:	178/466 - (38%)	Gaps:	112/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NQLHLYANGGASSSGPGGYRPAPSSQNEVYSIADSQPMTEDGYMPPSQHFP----PTHSDLDPPA 84
            :|:.:.....::|..|.|.|     :|.:...||.:...:..|....|.:.    .|.|......
  Fly    75 SQITVNRTSKSASVTPTGIR-----ENVMLPSADPEKEAQILYEKSLQEYHGSQLSTASTATDVI 134

  Fly    85 QQQSTCQTVCA------CKWKGGKQT--VECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQF 141
            ..:.|..::|.      |...|..:.  :.|....::.:|.::.....|||:..|.|..|....|
  Fly   135 AGKRTLHSICERWLQKHCHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSF 199

  Fly   142 IRA----------------------NLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLV 184
            ..|                      .|..|::|.|:||.:..:..::|:||..|..|.|:.|.||
  Fly   200 FMAPNLEELTLSDNSIINMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALV 264

  Fly   185 TVPSLALGHIPSLRELTLASNHIHKIESQA------------------------FGNTPSLHKLD 225
            ::....|||:..||.|.|..|..::|.:.|                        |...|:|..|.
  Fly   265 SLDGDCLGHLQKLRTLRLEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLL 329

  Fly   226 LSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDN--PWLCDCRL-RD 287
            |....|..|||.|...|..|.:|.|:.|.:|. ||:.:..||:|..:.:..|  .|:.|..| |.
  Fly   330 LKRNQIMKISAGALKNLTALKVLELDDNLISS-LPEGLSKLSQLQELSITSNRLRWINDTELPRS 393

  Fly   288 TKLWLMKRNIPYPVAPVCSGGPERIID---------RSFADLHVDEFACRP-EMLPISHYVEAAM 342
            .::..|:.|....::|....|..::..         |||.:|.    ||.. |:|.:.   .|.:
  Fly   394 MQMLDMRANPLSTISPGAFRGMSKLRKLILSDVRTLRSFPELE----ACHALEILKLD---RAGI 451

  Fly   343 GENASITCR--------------ARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEG---- 389
            .|..:..||              .:.:|  |::...:.|||..:|        :.:|:::|
  Fly   452 QEVPANLCRQTPRLKSLELKTNSLKRIP--NLSSCRDLRLLDLSS--------NQIEKIQGKPFN 506

  Fly   390 GFEKRSKLVLT 400
            |.::.:.|:|:
  Fly   507 GLKQLNDLLLS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	2/20 (10%)
		LRR_RI	<119..277	CDD:238064	54/203 (27%)
		leucine-rich repeat	123..148	CDD:275380	9/46 (20%)
		LRR_8	148..207	CDD:290566	22/58 (38%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	9/22 (41%)
		LRR_8	195..255	CDD:290566	22/83 (27%)
		leucine-rich repeat	197..220	CDD:275380	8/46 (17%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	13/61 (21%)
		IG_like	338..429	CDD:214653	15/81 (19%)
		Ig	346..426	CDD:143165	13/73 (18%)
rk	NP_476702.1	leucine-rich repeat	158..179	CDD:275380	2/20 (10%)
		LRR_RI	180..>383	CDD:238064	55/203 (27%)
		leucine-rich repeat	183..204	CDD:275380	8/20 (40%)
		LRR_8	203..263	CDD:290566	13/59 (22%)
		leucine-rich repeat	205..228	CDD:275380	1/22 (5%)
		leucine-rich repeat	229..252	CDD:275380	8/22 (36%)
		LRR_8	252..311	CDD:290566	16/58 (28%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..300	CDD:275380	7/22 (32%)
		LRR_8	299..359	CDD:290566	15/59 (25%)
		leucine-rich repeat	301..324	CDD:275380	1/22 (5%)
		leucine-rich repeat	325..348	CDD:275380	9/22 (41%)
		LRR_RI	327..567	CDD:238064	50/209 (24%)
		leucine-rich repeat	349..371	CDD:275380	8/22 (36%)
		LRR_8	370..425	CDD:290566	11/54 (20%)
		leucine-rich repeat	372..393	CDD:275380	5/20 (25%)
		leucine-rich repeat	394..415	CDD:275380	3/20 (15%)
		leucine-rich repeat	418..486	CDD:275380	14/76 (18%)
		leucine-rich repeat	441..464	CDD:275378	6/25 (24%)
		LRR_8	487..545	CDD:290566	9/39 (23%)
		leucine-rich repeat	487..510	CDD:275380	7/30 (23%)
		leucine-rich repeat	511..534	CDD:275380	2/7 (29%)
		LRR_8	533..589	CDD:290566
		leucine-rich repeat	535..558	CDD:275380
		leucine-rich repeat	559..580	CDD:275380
		7tm_4	764..>892	CDD:304433
		7tm_1	770..1017	CDD:278431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910