DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and kek4

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001260435.1	Gene:	kek4 / 34718	FlyBaseID:	FBgn0032484	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	642	Identity:	155/642 - (24%)
Similarity:	275/642 - (42%)	Gaps:	110/642 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 CACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLYLRNCK 158
            |.|||..||:|.:|.:..|..:||::.|..||||:|.|.:..|....|:..:|.|||||.:||..
  Fly    45 CHCKWNSGKKTADCRNLSLSGVPEYLSPEVQVLDLSHNHIFYLEENAFLTTHLQNLQKLLIRNGT 109

  Fly   159 IGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNTPSLHK 223
            :..:.:.:|..|..|:|||||:||||.:.......:..:|.:.|..|.:..:....|.|...|||
  Fly   110 LKYLNQRSFTQLQILIELDLSNNLLVDLLPNVFDCLSKVRAIFLNGNLLQALRHGVFRNLKYLHK 174

  Fly   224 LDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCRLRDT 288
            ::|....:.:|.|:||.|:..|:.:.|:.|:|::|..::.:.|::|..:.|.:|||.|.|.|:..
  Fly   175 IELKRNRLVSIDAKAFVGVPLLSQIYLDNNELTKLRVESFQDLTKLTALSLVENPWNCTCDLQMF 239

  Fly   289 KLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEML--PISHYVEAAMGENASITCR 351
            :.:::..|:..|  |.....|.::..|.:.:...:.|||:|:::  .:|..:..:. ||.::.||
  Fly   240 RDFVIGMNLYTP--PTSCHYPLQLRGRLWIEDQPEAFACKPKIVYPTLSTSINTSK-ENVTLICR 301

  Fly   352 ARAVPAANINWYWNGRLLANNS---AFTAYQRIH--MLEQVEGGFEK------RSKLVLTNAQET 405
            ....|...|.|.:..::..:.|   .....|||:  :|.:.|....|      .|:|.:.||:::
  Fly   302 VHGSPNTVIAWDYTNQVYESRSKPVKSLQKQRIYIELLREDESKIRKFGHDVFVSRLTIVNARKS 366

  Fly   406 DSSEFYCVAEN------------------RAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALV 452
            |...:.|:|||                  |..:.::||...|.:.|.|..|:.
  Fly   367 DEGVYTCLAENPGGKDSVHISVVVQKDMERISLIDSNFFAIVCLIAMGFLSMS------------ 419

  Fly   453 ALIVFALGVIMCLLLRVKRQPYVDSKT---PNHMEVITSVNHQNSITNKTQPATGNGSIGGVVIA 514
              |:|:|  :.||:.:..:|.:....|   |..:.|.:.         .::.||...::...||.
  Fly   420 --ILFSL--VTCLIFKRFKQFHPGQHTYLQPTSLPVQSP---------GSEEATAISALSSGVIR 471

  Fly   515 NGAVA----NIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGYDNNG 575
            ...:.    :.|:....:..||.:.|:..|.  ..:|.:.     .|..||....| |:..||..
  Fly   472 ESKIVLDPLSAINEPSNKNYTLFKTSNSNGS--EYMHTRN-----YKDVRLNSNTY-TENLDNQA 528

  Fly   576 SVLSTASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPPISGVGVGGSGEYSRANGCDSL 640
            ..:|:               .|.:|.::..  |..|..:||          ...|..:.:...||
  Fly   529 ESISS---------------RNRELYSNIA--GDREKEELK----------QKDELDKDSRQSSL 566

  Fly   641 YPSGLWEHGAPVGTTSADDLFMKRYTDKTPIIDSTQLYDLHERTAATDYFSKTFPRS 697
            ..:|.......:     |:|    ..|..|....|.|.:::|....:...::..|||
  Fly   567 QSTGCSRKKGQI-----DEL----QPDLLPSTQPTALKNINETFGPSAKKAEVNPRS 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	51/157 (32%)
		leucine-rich repeat	123..148	CDD:275380	9/24 (38%)
		LRR_8	148..207	CDD:290566	22/58 (38%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	10/22 (45%)
		LRR_8	195..255	CDD:290566	17/59 (29%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	6/22 (27%)
		LRRCT	277..327	CDD:214507	12/49 (24%)
		IG_like	338..429	CDD:214653	26/119 (22%)
		Ig	346..426	CDD:143165	23/108 (21%)
kek4	NP_001260435.1	leucine-rich repeat	75..99	CDD:275380	9/23 (39%)
		LRR_8	99..158	CDD:290566	22/58 (38%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR_8	146..206	CDD:290566	17/59 (29%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..195	CDD:275380	9/22 (41%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
		TPKR_C2	228..277	CDD:301599	13/50 (26%)
		IG_like	294..390	CDD:214653	23/95 (24%)
		Ig	296..387	CDD:143165	21/90 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010