DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and CG16974

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001246018.1	Gene:	CG16974 / 34713	FlyBaseID:	FBgn0032479	Length:	1257	Species:	Drosophila melanogaster

Alignment Length:	990	Identity:	191/990 - (19%)
Similarity:	311/990 - (31%)	Gaps:	360/990 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QVLDMSGNKLQTLSNEQFIR----------------------ANLLNLQKLYLRNCKIGEIERET 166
            ||||:|.|:|.:..:..|.|                      .:|..|::|.|....:..|:|:.
  Fly   326 QVLDLSDNRLLSFPDNFFARNGQLRQLHLQRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKA 390

  Fly   167 FKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNH------------------------- 206
            |:.|.:|:.|::|.|.|..:.|:....:.:||:|.|:.|.
  Fly   391 FESLDHLLALNVSGNNLTLLSSIIFQSLHALRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPI 455

  Fly   207 -------------------IHKIE--------------SQAFGNTPSLHKLDLSHCDIQTISAQA 238
                               :|::.              :..|.|||::.:|.|:...:..:..|
  Fly   456 EQFSNWISRYDESLVDPQVLHRLRYLSVQQNRKLTYLPATLFANTPNIRELLLAENGLLQLPTQ- 519

  Fly   239 FGGLQGLTLLRLNGNKLSELLPKTIETLSRLHGIELHDNPWLCDCRLRDTKLWLMKRNI----PY 299
            ..||..|..|.:.||.|.. ||:.|:.|.:||.:.:..|.:.|||.:.....||...:.    ..
  Fly   520 ISGLSRLQRLSVRGNSLGS-LPENIKELRQLHYLNILGNEYQCDCSMYWLTAWLANTSTSLRHQM 583

  Fly   300 PVAPVCSGGPER---IIDRSFADLHVDEFAC----RPEML-----------PISHYVEAAMGE-- 344
            |.|...|.|...   :......|..:|...|    |.:||           .:..:.|..|.:
  Fly   584 PQAQNHSNGSTNQTPLDSYESIDHQIDALKCQYGYRGDMLRVLSKLNCSVPTVVQFSEPKMHKLL 648

  Fly   345 -NASITCRARAVPAANINWYW------------NGRLLANNSAFTAY-----------------Q 379
             .|.:.|:....|..:|.|..            :.|.:..:|...|:                 |
  Fly   649 STAKLECQISGSPVPDIIWVTPRNKILRHHADPDKRPIIIDSKEDAHQPPSAQELAALMDESYIQ 713

  Fly   380 RIHMLEQ----------VEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAA 434
            .::...|          ||.|     .|::.|....||..:.|.|.|..|.|.|...|::.....
  Fly   714 SLNWTRQNSLVGRRVVLVENG-----SLLVHNISRIDSGLYTCYAFNVMGKASAGLRLYIDPIVF 773

  Fly   435 GMASLGS---GQIVGLSAALVALIVFAL-------GV---IMCLLLRVKRQP------------- 473
            ....:||   |..:..:..|:.|||..|       |:   ..|.:.|.|:.|
  Fly   774 YRVKIGSILFGTALATAFLLLTLIVQGLRSCLSRWGICNRFYCCVNRKKKSPRKHQIYAMLDSIE 838

  Fly   474 -YVDSKTPNHMEVITSVNH-------------QNSITNKTQPATGNGSIGGVVI----------- 513
             |...:.....|..|...|             |:|.|::.:.......||...:
  Fly   839 TYKSQQLERLRENYTQQVHRIRENCAQQVEWIQSSYTSQAKHIREFRDIGSNHLTTLKDQYYDQV 903

  Fly   514 ------ANGAVANIIDGGVVQGGTLERKSSGRGGVPHGV--------HDQRSANPVQKPPRLTDL 564
                  :.|.::.:.:..|.|...:.:.|:      |.|        :.|::.|.|     |.:|
  Fly   904 KKVRDYSTGQLSWVRENYVFQRNKIRKFSA------HQVLRLREGYKYQQQTLNKV-----LENL 957

  Fly   565 PYSTQGYDNNGSVLSTASCFISPSGSTGNGGNNPDLINDTKRF--GSDEFADLKIPPISGVGVGG 627
            |   ..|..|        |         .|....|:..|...:  |..:|.|.|...|..:....
  Fly   958 P---SFYFEN--------C---------RGRCEEDIAEDIDCYFKGQMDFGDSKELHIQKIKARL 1002

  Fly   628 SGEYSRANGCDSLYPSGLWEHGAPVGTTSADDLFMKRYTDKTPIIDSTQLYDLHERTAATDYFSK 692
            |..||.:..  |||            .|..||          .::.|:|| :|.......:|..:
  Fly  1003 SANYSASKA--SLY------------YTPPDD----------DLLHSSQL-NLQNSPIHINYIDE 1042

  Fly   693 TF-PRSHLQQGMMTGGGGGTSTASTVTTNLSGGSSSGYPNDYGLPLVPGAEHQ------HNHQLQ 750
            .. .:..|:.............||.:..|..|.||||   ........||..|      :|.:.:
  Fly  1043 NLDQQKQLEHDFKMEPQLLLYNASMLYMNPEGASSSG---QAAALAAAGALSQFISVEDNNQEQE 1104

  Fly   751 MHPLQQL-----------------------------QQQLTSTLNHQKQEG-------------- 772
            |.||:::                             :|:..|||:..::||
  Fly  1105 MQPLRKISGKPLGMPELKDLNDVKTSKSCPAIYKVSKQRDGSTLHELQKEGEAPYQMLRINPVET 1169

  Fly   773 -SSTGS-SPHFSSRTLPRLH--------------EGSGGGGSSRSSPTPA--------------- 806
             |.|.: :|...:|| .:|:              |..|..|:|.:.|:.:
  Fly  1170 TSLTSTVAPVMQART-EKLNIILDECGTASLCKAEQEGDAGNSETPPSESSCESNSLAASCGDVC 1233

  Fly   807 -VSGGHANQAANPST 820
             ||...||.|:.|||
  Fly  1234 QVSSKLANDASLPST 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380
		LRR_RI	<119..277	CDD:238064	49/232 (21%)
		leucine-rich repeat	123..148	CDD:275380	10/45 (22%)
		LRR_8	148..207	CDD:290566	18/102 (18%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR_8	195..255	CDD:290566	19/117 (16%)
		leucine-rich repeat	197..220	CDD:275380	9/80 (11%)
		leucine-rich repeat	221..244	CDD:275380	5/22 (23%)
		leucine-rich repeat	245..268	CDD:275380	9/22 (41%)
		LRRCT	277..327	CDD:214507	12/56 (21%)
		IG_like	338..429	CDD:214653	26/132 (20%)
		Ig	346..426	CDD:143165	23/118 (19%)
CG16974	NP_001246018.1	leucine-rich repeat	206..228	CDD:275380
		leucine-rich repeat	229..252	CDD:275380
		LRR_RI	<246..433	CDD:238064	28/106 (26%)
		LRR_8	251..311	CDD:290566
		leucine-rich repeat	253..276	CDD:275380
		leucine-rich repeat	277..300	CDD:275380
		leucine-rich repeat	301..324	CDD:275380
		LRR_8	325..383	CDD:290566	13/56 (23%)
		leucine-rich repeat	325..348	CDD:275380	9/21 (43%)
		leucine-rich repeat	349..372	CDD:275380	1/22 (5%)
		LRR_RI	351..>557	CDD:238064	40/207 (19%)
		LRR_8	371..431	CDD:290566	18/59 (31%)
		leucine-rich repeat	373..396	CDD:275380	7/22 (32%)
		leucine-rich repeat	397..420	CDD:275380	6/22 (27%)
		leucine-rich repeat	421..444	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	13/59 (22%)
		leucine-rich repeat	478..502	CDD:275380	3/23 (13%)
		leucine-rich repeat	503..526	CDD:275380	5/23 (22%)
		Ig	<714..761	CDD:299845	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010