DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and kek5

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	875	Identity:	220/875 - (25%)
Similarity:	354/875 - (40%)	Gaps:	174/875 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PPTHSDLDPPAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSN 138
            |||....|    ...:|.| |.|:|..||::.:|.::.|.:||:.:....||||.:.|::..|..
  Fly    31 PPTAGTTD----WMQSCGT-CHCQWNSGKKSADCKNKALTKIPQDMSNEMQVLDFAHNQIPELRR 90

  Fly   139 EQFIRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLA 203
            |:|:.|.|.|:.|::||||.|.|:.||.||||..|:|||||.|.:..:.......:..||.:.:.
  Fly    91 EEFLLAGLPNVHKIFLRNCTIQEVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIIN 155

  Fly   204 SNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSR 268
            :|.|..:.:..|.|...|.:::..:..::.:....|.|...|:.:.|..|:||.|..:|.:.|.:
  Fly   156 NNEIEVLPNHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQK 220

  Fly   269 LHGIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEFACRPEML- 332
            |..:.|..|.|.|.|.|:|.:.:.:.:.:..|  |.....|.::..:.::::..:.|||||.:|
  Fly   221 LMHLSLQGNAWNCSCELQDFRDFAISKRLYTP--PTDCQEPPQLRGKLWSEVPSENFACRPRILG 283

  Fly   333 PISHYVEAAMGENASITCRARAVPAANINWYWNGRLLANNSAFTAYQRIHMLEQVEGGFEK---- 393
            .:..::| |..:|.|:.||....|..|:.|.:|.|.|....     .|:.:|..||...|:
  Fly   284 SVRSFIE-ANHDNISLPCRIVGSPRPNVTWVYNKRPLQQYD-----PRVRVLTSVEQMPEQPSQV 342

  Fly   394 -RSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAA------- 450
             .|:|.:...:.:|...:.|||:||.|.|||.|.|.||...||..|...|..:|...|
  Fly   343 LTSELRIVGVRASDKGAYTCVADNRGGRAEAEFQLLVSGDYAGAVSASDGMGMGAIGAPTIDPQT 407

  Fly   451 ----LVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNGSIGGV 511
                ::.||:..|  ::.||:.|....:...:...:.:..|.::....|::| ...|.|||
  Fly   408 NMFLIICLIITTL--LLLLLVAVLTLFWYCRRIKTYQKDTTMMSGDGLISSK-MDKTHNGS---- 465

  Fly   512 VIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGYDNNGS 576
                     :::|.|:    :|.:.|....|          |||:||||.||:    :..|....
  Fly   466 ---------MLEGSVI----MEMQKSLLNEV----------NPVEKPPRRTDI----ESVDGGDD 503

  Fly   577 VLSTASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPPISGVGVGGSGEYSRANGCDSLY 641
            ||......:..:....|...:.:.:       |...:|....|           .||....|..|
  Fly   504 VLEIKKTLLDDTVYVANHSRDEEAV-------SVAMSDTTTTP-----------RSRHTYVDDAY 550

  Fly   642 PSGLWEHGAPVGTTSADDL--FMKRYTDKTPIIDSTQ-------LYDLHERTAATDYFSKTFPRS 697
            .:.|           ..||  |..|....:|.:.|:|       :|.:....:.|         |
  Fly   551 ANSL-----------PPDLLAFPARVPPTSPSMQSSQSNIPDQVIYGIRSPPSLT---------S 595

  Fly   698 HLQQGMMTGGGGGTSTASTVTTNLSGGSSSGYPNDYGLPLV----PGAEHQHNHQLQM-----HP 753
            .:...|...|..||   .|:|...:|..:..:|....|.|:    ...:|||:||||.     |.
  Fly   596 PVYTHMTPHGIYGT---KTMTAPHNGFMTLQHPKSRNLALIATTNSSRQHQHHHQLQQQQQHHHH 657

  Fly   754 LQQLQQQLTSTLNHQKQEGSSTGSSPHFSS----------------RTLPR---------LHEGS 793
            .||.|||      .|:|:.....:||...:                .|:||         ...|:
  Fly   658 HQQQQQQ------QQQQQHPLATTSPFLPAPVVYSPATGVVMKQGYMTIPRKPRAPSWAPSTSGA 716

  Fly   794 GGGGS-------SRSSPTPAVSG--GHANQAANPSTSSSSCSILPNGQPINAKTIRVWQKGG--- 846
            .|.||       |.:||.|:.:|  ..|...|.|...:........|......|.....:||
  Fly   717 AGHGSIQLSEFQSPTSPNPSETGTATTAELQAEPVYDNLGLRTTAGGNSTLNLTKIAGSQGGAGQ 781

  Fly   847 --------VPVLPPVTALKRALISSSRNSP 868
                    :|..|.:|::..|..:|....|
  Fly   782 QYSMRDRPLPATPSLTSVSSATNASKIYEP 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	4/18 (22%)
		LRR_RI	<119..277	CDD:238064	50/157 (32%)
		leucine-rich repeat	123..148	CDD:275380	10/24 (42%)
		LRR_8	148..207	CDD:290566	24/58 (41%)
		leucine-rich repeat	149..172	CDD:275380	13/22 (59%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	195..255	CDD:290566	12/59 (20%)
		leucine-rich repeat	197..220	CDD:275380	6/22 (27%)
		leucine-rich repeat	221..244	CDD:275380	3/22 (14%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		LRRCT	277..327	CDD:214507	10/49 (20%)
		IG_like	338..429	CDD:214653	31/95 (33%)
		Ig	346..426	CDD:143165	26/84 (31%)
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	34/83 (41%)
		leucine-rich repeat	76..100	CDD:275380	10/23 (43%)
		LRR_8	99..159	CDD:290566	24/59 (41%)
		leucine-rich repeat	101..124	CDD:275380	13/22 (59%)
		LRR	122..145	CDD:197688	8/22 (36%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR_8	148..207	CDD:290566	12/58 (21%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	3/22 (14%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	8/22 (36%)
		LRRCT	229..277	CDD:214507	10/49 (20%)
		Ig	296..376	CDD:143165	26/84 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005302
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910