DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek1 and Lrrc4c

DIOPT Version :9

Sequence 1:NP_001303320.1 Gene:kek1 / 34688 FlyBaseID:FBgn0015399 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_001101223.1 Gene:Lrrc4c / 311236 RGDID:1311013 Length:640 Species:Rattus norvegicus


Alignment Length:504 Identity:129/504 - (25%)
Similarity:198/504 - (39%) Gaps:111/504 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 TCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANLLNLQKLY 153
            ||.:||:|..:..|  |.|:.::|.::|:.|..||::|::..|::|.:....|  .:|.:|:.|.
  Rat    46 TCPSVCSCSNQFSK--VICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSF--KHLRHLEILQ 106

  Fly   154 LRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIESQAFGNT 218
            |....|..||...|.||.||..|:|..|.|.|:|:.|..::..|:||.|.:|.|..|.|.||...
  Rat   107 LSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRI 171

  Fly   219 PSLHKLDLSH-------------------------CD---------------------------- 230
            |||.:|||..                         |:                            
  Rat   172 PSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRP 236

  Fly   231 ------------------IQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIET-LSRLHGIELHD 276
                              ||.|...||..||.|..:.|..|.|: |||..:.| |..|..|.||.
  Rat   237 GSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLT-LLPHDLFTPLHHLERIHLHH 300

  Fly   277 NPWLCDCRLRDTKLWLMKRNIPYPVAPVCS--GGPERIIDRSFADLHVDEFAC-RPEMLPISHYV 338
            |||.|:|.:.....|:  |::.......|:  ..|..:..|...:|..:.|.| .|.::.....:
  Rat   301 NPWNCNCDILWLSWWI--RDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADL 363

  Fly   339 EAAMGENASITCRARAVPAANINWYW-NGRLLANNSAFTAYQ-RIHMLEQVEGGFEKRSKLVLTN 401
            ....|..|.:.||| :....:::|.. ||.::.:.    ||: ||.:|..        ..|..||
  Rat   364 NVTEGMAAELKCRA-STSLTSVSWITPNGTVMTHG----AYKVRIAVLSD--------GTLNFTN 415

  Fly   402 AQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMASLGSGQIVGLSAALVALIVFALGVIMCLL 466
            ....|:..:.|:..|..|...|:.||:|:.......|.       .|...|..:..:........
  Rat   416 VTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSY-------FSTVTVETMEPSQDEARTTD 473

  Fly   467 LRVKRQPYVDSKTPNHMEVITSVNHQNSITNK---TQPATG-NGSIGGV 511
            ..|...|.:|.:|.|   |.||:..|::.:.:   |.|.|. |..|.|:
  Rat   474 NNVGPTPVIDWETTN---VTTSLTPQSTRSTEKTFTIPVTDINSGIPGI 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek1NP_001303320.1 leucine-rich repeat 103..122 CDD:275380 5/18 (28%)
LRR_RI <119..277 CDD:238064 63/229 (28%)
leucine-rich repeat 123..148 CDD:275380 6/24 (25%)
LRR_8 148..207 CDD:290566 23/58 (40%)
leucine-rich repeat 149..172 CDD:275380 9/22 (41%)
leucine-rich repeat 173..196 CDD:275380 8/22 (36%)
LRR_8 195..255 CDD:290566 27/130 (21%)
leucine-rich repeat 197..220 CDD:275380 10/22 (45%)
leucine-rich repeat 221..244 CDD:275380 11/93 (12%)
leucine-rich repeat 245..268 CDD:275380 9/23 (39%)
LRRCT 277..327 CDD:214507 12/51 (24%)
IG_like 338..429 CDD:214653 23/92 (25%)
Ig 346..426 CDD:143165 20/81 (25%)
Lrrc4cNP_001101223.1 LRRNT 47..80 CDD:214470 12/34 (35%)
PPP1R42 65..235 CDD:411060 45/171 (26%)
leucine-rich repeat 78..101 CDD:275380 6/24 (25%)
leucine-rich repeat 102..125 CDD:275380 9/22 (41%)
leucine-rich repeat 126..149 CDD:275380 8/22 (36%)
leucine-rich repeat 150..173 CDD:275380 10/22 (45%)
leucine-rich repeat 174..198 CDD:275380 4/23 (17%)
leucine-rich repeat 199..220 CDD:275380 1/20 (5%)
LRR_8 220..279 CDD:404697 10/58 (17%)
leucine-rich repeat 221..244 CDD:275380 0/22 (0%)
leucine-rich repeat 245..268 CDD:275380 6/22 (27%)
LRR_8 267..>301 CDD:404697 14/34 (41%)
leucine-rich repeat 269..290 CDD:275380 8/21 (38%)
LRRCT 301..>339 CDD:214507 9/39 (23%)
IG 360..443 CDD:214652 23/95 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46071
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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