DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek1 and Lrrc55

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001381943.1	Gene:	Lrrc55 / 311171	RGDID:	1561726	Length:	311	Species:	Rattus norvegicus

Alignment Length:	268	Identity:	68/268 - (25%)
Similarity:	103/268 - (38%)	Gaps:	78/268 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HSDLDPPAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQF 141
            |||..      ::|..:|.|:    .|.|:|.::.|..:|..:..:|:.|.::.|::..:.....
  Rat    44 HSDAG------ASCPVLCTCR----NQVVDCSNQRLFSVPPDLPMDTRNLSLAHNRIAAVPPGYL 98

  Fly   142 IRANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPS-----------LALGHIP 195
              ...:.|:.|.|||..:.|:....|.....|..||||:|.|..||:           :.|.|.|
  Rat    99 --TCYMELRVLDLRNNSLMELPPGLFLHAKRLAHLDLSYNNLSHVPADMFREAHGLVHIDLSHNP 161

  Fly   196 SLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSELLP 260
            .||          ::..|||.....|..||||:..:..:|.:|..||.||..|::.|
  Rat   162 WLR----------RVHPQAFQGLVHLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGG-------- 208

  Fly   261 KTIETLSRLHGIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPERIIDRSFADLHVDEF 325
                            |||:|.|.:.....||..|                 |.|..||..:.|
  Rat   209 ----------------NPWVCGCTMEPLLKWLRNR-----------------IQRCTADSQLAE- 239

  Fly   326 ACR--PEM 331
             ||  ||:
  Rat   240 -CRGPPEV 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	40/168 (24%)
		leucine-rich repeat	123..148	CDD:275380	3/24 (13%)
		LRR_8	148..207	CDD:290566	21/69 (30%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	11/33 (33%)
		LRR_8	195..255	CDD:290566	19/59 (32%)
		leucine-rich repeat	197..220	CDD:275380	5/22 (23%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	3/22 (14%)
		LRRCT	277..327	CDD:214507	13/49 (27%)
		IG_like	338..429	CDD:214653
		Ig	346..426	CDD:143165
Lrrc55	NP_001381943.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910