DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and Lrrc4b

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_001258010.1	Gene:	Lrrc4b / 308571	RGDID:	1307121	Length:	709	Species:	Rattus norvegicus

Alignment Length:	845	Identity:	173/845 - (20%)
Similarity:	252/845 - (29%)	Gaps:	336/845 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PPAQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIRANL 146
            |||   ::|...|:|..:..:  |.|..|.|.::|..|..||:.|::..|.:|.:..:.|  .:|
  Rat    54 PPA---TSCPAACSCSNQASR--VICTRRELAEVPASIPVNTRYLNLQENSIQVIRTDTF--KHL 111

  Fly   147 LNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLALGHIPSLRELTLASNHIHKIE 211
            .:|:.|.|....:.:||...|.||.:|..|:|..|.|.|||:.|..::..||||.|.:|.|..|.
  Rat   112 RHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIP 176

  Fly   212 SQAFGNTPSLHKLDLS------------------------------------------------- 227
            |.||...|||.:|||.
  Rat   177 SYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGN 241

  Fly   228 ----------------------HCDIQTISAQAFGGLQGLTLLRLNGNKLSELLPKTIETLSRLH 270
                                  |..:.||...||..|:.|..|.|:.|.|..|.......|.||.
  Rat   242 RLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLE 306

  Fly   271 GIELHDNPWLCDCRLRDTKLWL---MKRNIPYPVAPVCS--GGPERIIDRSFADLHVDEFAC-RP 329
            .:.|:.|||.|:|.:    |||   :|..:|.... .|:  ..|..:..|...:|....|.| .|
  Rat   307 RVHLNHNPWHCNCDV----LWLSWWLKETVPSNTT-CCARCHAPAGLKGRYIGELDQSHFTCYAP 366

  Fly   330 EMLPISHYVEAAMGENASITCRARAVPAANINWYW-NGRLLANNSAFTAYQ-RIHMLEQVEGGFE 392
            .::.....:....|..|.:.||. .....::||.. ||.|:.:.|    |: ||.:|..
  Rat   367 VIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGS----YRVRISVLHD------ 420

  Fly   393 KRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVS----MRAAGMASLGSGQIVGLSAALVA 453
              ..|..||....|:.::.|:..|.||...|:.||:||    :.|.|....|.|
  Rat   421 --GTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGPGGGGPG----------- 472

  Fly   454 LIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNHQNSITNKTQPATGNGSIGGVVIANGAV 518
                                                              |.|..||.
  Rat   473 --------------------------------------------------GGGGAGGA------- 480

  Fly   519 ANIIDGG-----VVQGGTLERKSSGRGGVPHGVHDQRSANPVQKPPRLTDLPYSTQGYDNNGSVL 578
                 ||     .|...|||.:.......|.|..        ::||
  Rat   481 -----GGYTYFTTVTVETLETQPGEEAQQPRGTE--------KEPP------------------- 513

  Fly   579 STASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIPPISGVGVGGSGEYSRANGCDSLYPS 643
                   .|:.....||..||.
  Rat   514 -------GPTTDGAWGGGRPDA------------------------------------------- 528

  Fly   644 GLWEHGAPV-GTTSADDLFMKRYTDK---TPIIDSTQ--LYDLHERTAATD-----YFSKTFPRS 697
                 .||. .:|:|......|.|:|   .||.|.|:  |.||.:....|.     :.:.||..:
  Rat   529 -----AAPASASTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAA 588

  Fly   698 HL--------QQGMMTGGGGGTSTASTVTTN----------------LSGGSSSGYPNDYGLPLV 738
            .:        :|..:....|.|.|...:...                ::||:..|..:...||.:
  Rat   589 VMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVAGGAGVGGDSHLALPAL 653

  Fly   739 PGAEHQHNHQLQMHPLQQLQQQLTSTLNHQKQEGSSTGSSPHFSSRTLPRLHEGSGGGGSSRSSP 803
               |..|                   |||.           |:.:......:.|:.|||.....|
  Rat   654 ---ERDH-------------------LNHH-----------HYVAAAFKAHYGGNPGGGCGAKGP 685

Fly 804 803
Rat 686 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	6/18 (33%)
		LRR_RI	<119..277	CDD:238064	58/228 (25%)
		leucine-rich repeat	123..148	CDD:275380	6/24 (25%)
		LRR_8	148..207	CDD:290566	23/58 (40%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		leucine-rich repeat	173..196	CDD:275380	9/22 (41%)
		LRR_8	195..255	CDD:290566	27/130 (21%)
		leucine-rich repeat	197..220	CDD:275380	11/22 (50%)
		leucine-rich repeat	221..244	CDD:275380	10/93 (11%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRRCT	277..327	CDD:214507	15/54 (28%)
		IG_like	338..429	CDD:214653	25/92 (27%)
		Ig	346..426	CDD:143165	22/81 (27%)
Lrrc4b	NP_001258010.1	LRRNT	59..92	CDD:214470	11/34 (32%)
		LRR	<89..299	CDD:227223	53/211 (25%)
		LRR 1	89..110		6/22 (27%)
		leucine-rich repeat	90..113	CDD:275380	6/24 (25%)
		LRR 2	113..134		6/20 (30%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR 3	137..158		9/20 (45%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		LRR 4	161..182		11/20 (55%)
		leucine-rich repeat	162..185	CDD:275380	11/22 (50%)
		LRR 5	185..207		5/21 (24%)
		leucine-rich repeat	186..210	CDD:275380	4/23 (17%)
		LRR 6	210..231		0/20 (0%)
		leucine-rich repeat	211..232	CDD:275380	0/20 (0%)
		LRR 7	232..253		0/20 (0%)
		leucine-rich repeat	233..256	CDD:275380	0/22 (0%)
		LRR 8	256..277		5/20 (25%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		LRR 9	280..301		6/20 (30%)
		leucine-rich repeat	281..302	CDD:275380	6/20 (30%)
		LRRCT	313..363	CDD:214507	15/54 (28%)
		I-set	366..455	CDD:400151	26/101 (26%)
		Ig strand A	366..369	CDD:409353	1/2 (50%)
		Ig strand A'	373..376	CDD:409353	0/2 (0%)
		Ig strand B	382..389	CDD:409353	2/6 (33%)
		Ig strand C	395..400	CDD:409353	2/4 (50%)
		Ig strand C'	403..405	CDD:409353	1/1 (100%)
		Ig strand D	414..418	CDD:409353	2/3 (67%)
		Ig strand E	421..425	CDD:409353	1/3 (33%)
		Ig strand F	435..442	CDD:409353	1/6 (17%)
		Ig strand G	445..455	CDD:409353	4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..552		16/137 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46071
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910