DRSC/TRiP Functional Genomics Resources

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Protein Alignment kek1 and Lingo2

DIOPT Version :9

Sequence 1:NP_001303320.1 Gene:kek1 / 34688 FlyBaseID:FBgn0015399 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_001159471.1 Gene:Lingo2 / 242384 MGIID:2442298 Length:606 Species:Mus musculus


Alignment Length:626 Identity:142/626 - (22%)
Similarity:211/626 - (33%) Gaps:253/626 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 CQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIR----------- 143
            |...|.|  ....::|.|..|.|:.|||.|...|::||:|.|:|::::.|:||.           
Mouse    28 CPARCEC--SAQNKSVSCHRRRLLAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSD 90

  Fly   144 -----------ANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLS---------------HNL 182
                       .||.||:.|.|:..::..:....|.||:||.:||:|               |||
Mouse    91 NIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNL 155

  Fly   183 ----------------------------------------------------------------- 182
                                                                             
Mouse   156 KSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPVYA 220

  Fly   183 ----------------------------------------LVTVPSLALGHIPSLRELTLASNHI 207
                                                    |.|||.||..|:..|..|.|:.|.|
Mouse   221 FKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLTHLNLSYNPI 285

  Fly   208 HKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLSEL------LPKTIETL 266
            ..||:..|.:...|.:|.:....::||...:|.||:.|.:|.::.|.|..|      .|:.:|.|
Mouse   286 STIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVL 350

  Fly   267 SRLHGIELHDNPWLCDCRLRDTKLWLMKR--NIPY-PVAPVCSGGPERIIDRSFADLHVDE---- 324
            |      :::||..|||||    |||::|  |:.: ...|:|: ||:.|.:|||.|.|...    
Mouse   351 S------INNNPLACDCRL----LWLLQRQPNLQFGGQQPMCA-GPDTIRERSFKDFHSTALSFY 404

  Fly   325 FACRPEML---PISHYVEAAMGENASITCRARAVPAANINWYW----------NGRLLANNSAFT 376
            |.|:...:   .:.|.: ...|:...:.|.|...|...|:|..          |||.....    
Mouse   405 FTCKKPKIREKKLQHLL-VDEGQTVQLECNADGDPQPVISWVTPRRRFITTKSNGRATVLG---- 464

  Fly   377 AYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMAS--- 438
                       :|..|.|.      ||:.||..:.|:|.|.||    |.|...|:...|..|   
Mouse   465 -----------DGTLEIRF------AQDQDSGMYVCIASNAAG----NDTFTASLTVKGFTSDRF 508

  Fly   439 ----------LGSGQIV--GLSAALVA------LIVFALG-------VIMCLLLRVKRQPYVDSK 478
                      ..|...|  |.:|...:      |:..|:|       |:.|.||.     :|.|:
Mouse   509 LYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLL-----FVWSR 568

  Fly   479 TPNHMEVITSVNHQNSITNKTQPATGNGSIGGVVIANGAVA 519
            ...        .|:|||..:..|...||:     :..|.||
Mouse   569 GKG--------KHKNSIDLEYVPRKNNGA-----VVEGEVA 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek1NP_001303320.1 leucine-rich repeat 103..122 CDD:275380 8/18 (44%)
LRR_RI <119..277 CDD:238064 58/305 (19%)
leucine-rich repeat 123..148 CDD:275380 11/46 (24%)
LRR_8 148..207 CDD:290566 26/178 (15%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
leucine-rich repeat 173..196 CDD:275380 14/142 (10%)
LRR_8 195..255 CDD:290566 18/59 (31%)
leucine-rich repeat 197..220 CDD:275380 8/22 (36%)
leucine-rich repeat 221..244 CDD:275380 7/22 (32%)
leucine-rich repeat 245..268 CDD:275380 8/28 (29%)
LRRCT 277..327 CDD:214507 23/56 (41%)
IG_like 338..429 CDD:214653 23/100 (23%)
Ig 346..426 CDD:143165 21/89 (24%)
Lingo2NP_001159471.1 LRRNT 27..60 CDD:214470 11/33 (33%)
leucine-rich repeat 39..57 CDD:275380 8/17 (47%)
LRR 1 58..79 8/20 (40%)
leucine-rich repeat 59..82 CDD:275380 9/22 (41%)
LRR_8 60..117 CDD:404697 14/56 (25%)
LRR 2 82..103 0/20 (0%)
leucine-rich repeat 83..106 CDD:275380 2/22 (9%)
LRR_8 106..165 CDD:404697 15/58 (26%)
LRR 3 106..127 5/20 (25%)
leucine-rich repeat 107..130 CDD:275380 6/22 (27%)
LRR 4 130..151 5/20 (25%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
LRR 5 154..175 2/20 (10%)
leucine-rich repeat 155..178 CDD:275380 1/22 (5%)
PPP1R42 176..>373 CDD:411060 42/206 (20%)
LRR 6 178..199 0/20 (0%)
leucine-rich repeat 179..202 CDD:275380 0/22 (0%)
LRR 7 202..223 0/20 (0%)
leucine-rich repeat 203..250 CDD:275380 0/46 (0%)
LRR 8 226..247 0/20 (0%)
LRR 9 250..271 6/20 (30%)
leucine-rich repeat 251..274 CDD:275380 7/22 (32%)
LRR 10 274..295 8/20 (40%)
leucine-rich repeat 275..298 CDD:275380 8/22 (36%)
LRR 11 298..319 5/20 (25%)
leucine-rich repeat 299..322 CDD:275380 7/22 (32%)
LRR 12 322..343 5/20 (25%)
leucine-rich repeat 323..343 CDD:275380 5/19 (26%)
LRRCT 355..408 CDD:214507 23/57 (40%)
Ig 411..500 CDD:416386 25/114 (22%)
Ig strand A' 417..421 CDD:409353 1/3 (33%)
Ig strand B 427..436 CDD:409353 2/8 (25%)
Ig strand C 441..446 CDD:409353 2/4 (50%)
Ig strand C' 449..451 CDD:409353 0/1 (0%)
Ig strand D 460..463 CDD:409353 0/2 (0%)
Ig strand E 466..473 CDD:409353 3/12 (25%)
Ig strand F 479..487 CDD:409353 2/7 (29%)
Ig strand G 490..500 CDD:409353 4/13 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8825
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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