DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek1 and Lrfn5

DIOPT Version :9

Sequence 1:	NP_001303320.1	Gene:	kek1 / 34688	FlyBaseID:	FBgn0015399	Length:	880	Species:	Drosophila melanogaster
Sequence 2:	NP_848829.2	Gene:	Lrfn5 / 238205	MGIID:	2144814	Length:	746	Species:	Mus musculus

Alignment Length:	877	Identity:	170/877 - (19%)
Similarity:	285/877 - (32%)	Gaps:	286/877 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 AQQQSTCQTVCACKWKGGKQTVECIDRHLIQIPEHIDPNTQVLDMSGNKLQTLSNEQFIR----- 143
            |.:...|...|.|:.........|..:.|:.:|.:||..|..|.::.|.:..:..:.|..
Mouse    14 AVRAQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTSLV 78

  Fly   144 -----------------ANLLNLQKLYLRNCKIGEIERETFKGLTNLVELDLSHNLLVTVPSLAL 191
                             |:|.||:.|:|.:.::.:|..:.|.||:||..|.|::|.|..:.|.|.
Mouse    79 DLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLTLISSTAF 143

  Fly   192 GHIPSLRELTLASNHIHKIESQAFGNTPSLHKLDLSHCDIQTISAQAFGGLQGLTLLRLNGNKLS 256
            ..:.:|.||.|:.|::..|...|.....|||.|.|.|..|..|....|..|..:|.|.:..|||.
Mouse   144 DDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDVTSNKLQ 208

  Fly   257 ELLPKTIETLSRL-----------HGIELHDNPWLCDCRLRDTKLWLMKRNIPYPVAPVCSGGPE 310
            :|.|..:...:::           ..:....||..|:|.|    |||.:.:....:....|  |.
Mouse   209 KLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCEL----LWLRRLSREDDLETCAS--PA 267

  Fly   311 RIIDRSFADLHVDEFACRPEMLP-ISHYVEAAMGENASITCRARAVPAANINWYW-NGRLLANNS 373
            .:..|.|..:..:||.|.|.::. .:|.:....|:.|::.|:||..|...|:|.. .|:|::|.:
Mouse   268 LLTGRYFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNAT 332

  Fly   374 AFTAYQRIHMLEQVEGGFEKRSKLVLTNAQETDSSEFYCVAENRAGMAEANFTLHVSMRAAGMAS 438
            ....|.        .|..:    :::|..::|.:  |.|:|.|.||.|.....||:
Mouse   333 RSLVYD--------NGTLD----ILITTVKDTGA--FTCIASNPAGEATQTVDLHI--------- 374

  Fly   439 LGSGQIVGLSAALVALIVFALGVIMCLLLRVKRQPYVDSKTPNHMEVITSVNH-------QNSIT 496
                                                  .|.|:   ::.|.||       .:.|:
Mouse   375 --------------------------------------IKLPH---LLNSTNHIHEPDPGSSDIS 398

  Fly   497 NKTQPATGNGSIGG--------VVIANGAVANIIDGGVVQGGTLERKSSGRGGVPHGVHDQRSAN 553
            ..|:..:...|..|        :|:|...           ..|...|.:.:..:| |:
Mouse   399 TSTKSGSNASSSNGDTKMSQDKIVVAEAT-----------SSTALLKFNFQRNIP-GI------- 444

  Fly   554 PVQKPPRLTDLPYSTQGYDNNGSVLSTASCFISPSGSTGNGGNNPDLINDTKRFGSDEFADLKIP 618
                  |:..:.|       ||:.                               .|......||
Mouse   445 ------RMFQIQY-------NGTY-------------------------------DDTLVYRMIP 465

  Fly   619 PISGVGVGGSGEYSRANGCDSLYPSGLWEHGAPVGTTSADDLFMKRYTDKTPIIDSTQLYDLHER 683
            |.|...:..    :.|:|                  |..|...:..|.|....:.:|::....:.
Mouse   466 PTSKTFLVN----NLASG------------------TMYDLCVLAIYDDGITSLTATRVVGCIQF 508

  Fly   684 TAATDYFSKTFPRSHLQQGMMTGGG-----GGTSTASTV-----------TTNLSGGSSSGYPND 732
            |...||.     |.|..|....||.     ||...||.:           ..|.:|
Mouse   509 TTEQDYV-----RCHFMQSQFLGGTMIIIIGGIIVASVLVFIIILMIRYKVCNNNG--------- 559

  Fly   733 YGLPLVPGAEHQHNHQLQMHPLQQLQQQLTSTLNHQKQEGSSTGSSPHFSSRTLPRLHEGSGGGG 797
                                     |.::|...|...|   :.|:.....|.|||:.......|.
Mouse   560 -------------------------QHKVTKVSNVYSQ---TNGAQMQGCSVTLPQSMSKQAMGH 596

  Fly   798 SSRSSPTPAVSGG--HANQAANPSTSSSSCSILP----NGQPINAKTIRVWQKGGVPVLPP---- 852
            ...:......|..  .:::..:...||::.|.||    :..|::.|..|  :.|..|...|
Mouse   597 EENAQCCKVASDNAIQSSETCSSQDSSTTTSALPPTWTSSAPVSQKQKR--KTGTKPSAEPQSEA 659

  Fly   853 VTALKRALISSSRNS---------PDEGYQEG 875
            ||.::..  :::||:         |.:...||
Mouse   660 VTNVESQ--NTNRNNSTALQLASCPPDSVTEG 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek1	NP_001303320.1	leucine-rich repeat	103..122	CDD:275380	5/18 (28%)
		LRR_RI	<119..277	CDD:238064	48/190 (25%)
		leucine-rich repeat	123..148	CDD:275380	6/46 (13%)
		LRR_8	148..207	CDD:290566	21/58 (36%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		leucine-rich repeat	173..196	CDD:275380	7/22 (32%)
		LRR_8	195..255	CDD:290566	20/59 (34%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		leucine-rich repeat	221..244	CDD:275380	9/22 (41%)
		leucine-rich repeat	245..268	CDD:275380	7/22 (32%)
		LRRCT	277..327	CDD:214507	14/49 (29%)
		IG_like	338..429	CDD:214653	23/91 (25%)
		Ig	346..426	CDD:143165	21/80 (26%)
Lrfn5	NP_848829.2	LRR 1	52..73		4/20 (20%)
		leucine-rich repeat	53..76	CDD:275380	4/22 (18%)
		LRR_8	55..111	CDD:338972	9/55 (16%)
		LRR 2	76..97		0/20 (0%)
		leucine-rich repeat	77..100	CDD:275380	2/22 (9%)
		LRR_8	100..159	CDD:338972	21/58 (36%)
		LRR 3	100..121		6/20 (30%)
		leucine-rich repeat	101..124	CDD:275380	7/22 (32%)
		LRR 4	124..145		8/20 (40%)
		leucine-rich repeat	125..148	CDD:275380	7/22 (32%)
		LRR 5	148..169		7/20 (35%)
		LRR_8	149..207	CDD:338972	20/57 (35%)
		leucine-rich repeat	149..172	CDD:275380	7/22 (32%)
		LRR 6	172..193		9/20 (45%)
		leucine-rich repeat	173..196	CDD:275380	9/22 (41%)
		LRR 7	196..217		7/20 (35%)
		leucine-rich repeat	197..215	CDD:275380	7/17 (41%)
		TPKR_C2	240..>272	CDD:387596	10/37 (27%)
		Ig_2	301..374	CDD:143241	23/86 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..416		6/30 (20%)
		fn3	421..493	CDD:365830	20/156 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8450
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940